Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 487 for “"E3"”.
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An Experimental Investigation of Neutral Kaon-E3
Made available in DSpace on 2015-05-12T21:41:32Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 6507096.PDF: 3811685 bytes, checksum: 3f5fd0ec11c69e5dc68e082b916aaf18 (MD5) Previous issue date: 1965
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Characterization of the Human Adenovirus 19a E3/49K Protein
… unit, the early transcription unit 3 (E3), appears to encode exclusively proteins with immuno-modulatory functions. Recently, a novel open reading frame, E3/49K, was identified in the E3 region of the epidemic keratoconjunctivitis causing serotype Ad19a. The sequence predicts a type I …
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Interaction Between Two E3 ligases, NEDD8ylated Cullin and HHARI
… between RING-RING2) is a special type of E3 ubiquitin ligase containing three zinc-binding RING (Really Interesting New Gene) domains, while adopting mechanisms of HECT (Homologous to E6-AP Carboxyl Terminus) for substrate ubiquitination. Most well known RBRs include Parkin and HOIP, which …
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Ubiquitin E3 ligase mediated regulation of HMG-CoA Reductase
… of HMGCR with Insig proteins, which recruit E3 ubiquitin ligase complexes to mediate degradation of HMGCR by the ubiquitin proteasome system. However, the identity of the E3 ligase(s) responsible for HMGCR ubiquitination is controversial. Here, I use a series of genome-wide CRISPR knockout …
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Design and Synthesis of an E3 ligase Activity-Based Probe and its Application for the Discovery of a New Class of E3 Ligase
… The distinct transfer cascade, involving E1-E2-E3 enzymes, serves as a promising target for drug development. However, E3 ligases (E3s) represent an important class of enzymes yet there are currently no effective tools for profiling their activity. Herein, a new class of E3 activity-based probe …
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The Role of Two Homologous E3 Ligases In Muscle Physiology
… enzyme, E2 ubiquitin conjugating enzyme, and E3 ubiquitin ligases. There are an estimated 600 E3 ligases, some of which share high sequence homology; however, the functional significance often remains unknown. FBXL3 and FBXL21 are two homologous E3 ligases that have previously been reported to …
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Roles for the E3 Ligase Itch in Immune Response Modulation
… in the agouti mutant strain a has implicated the E3 ligase Itch in the spontaneous inflammation that occurs in these mice. 1 RH Anaylsis of a mice suggests that the inflammatory disease is due to a dysregulated T helper type-2 immune response. In order to verify the importance of Itch inactivation …
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MECHANISMS OF SUBSTRATE DEGRADATION AND RECRUITMENT BY CULLIN E3 LIGASES
… protein degradation, is mediated by the Cullin E3 ubiquitin ligase family. The aim of this study is to achieve a better understanding of the function and regulation of Cullin E3 ligases. We studied the degradation of insulin receptor substrate 1 (IRS1) by the Cullin5 E3 ligase, and found that …
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Investigating the protein targets of the neuroprotective E3 ligase, CHIP
… proteostasis is the dual function chaperone and E3 ligase C-terminus of Hsc-70 interacting protein (CHIP). Its role in neurodegenerative diseases, including dementia with Lewy bodies, and the severe progeria and proteotoxic phenotype seen in CHIP KO mice support its neuroprotective effects, but …
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Regulation of the Parkin E3 ligase by PINK1-dependent phosphorylation
… Parkin encodes a RING-In Between RING-RING E3 ligase that normally resides in the cytoplasm and is<br/>regulated by autoinhibitory intramolecular interactions. PINK1 is a mitochondrial Ser/Thr kinase that is unique in possessing a N-terminal mitochondrial targeting sequence and three loop …
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Impact of MHD-E3 on power system equipment and loads.
… – the magnetohydrodynamic late-time or MHD-E3 pulse – is characterized by a strong yet minute-long electric field that is capable of inducing quasi-direct currents in long conductors such as electric transmission lines. These quasi-direct currents, on the order of 1000 amps within the power …
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Origins and composition of the cullin-RING E3 ligases in trypanosomes
… the E2s and eventually their recruitment to an E3 ligase that will transfer it to the substrate. Cullin-RING is a prominent family of E3 ligases responsible for ubiquitylation of up to 20% of the human proteome. In contrast with the rest of the class, cullin-RINGs perform their function as …
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바이러스 감염시 미토콘드리아 E3 ubiquitin ligase 인 MARCH5의 새로운 생체 기능
… I investigated functional role of mitochondrial E3 ligase, MARCH5, against protein aggregated at the mitochondria membranes. First, the mitochondrial antiviral signaling (MAVS) protein forms aggregates that elicit robust type-I interferon induction on viral infection, but persistent MAVS …
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Investigations into the Biological Roles of the E3 ligase Ariadne 2/TRIAD1
… of immune responses. Ariadne 2 is a RING finger E3 ligase and is part of the highly conserved RBR (RING-B-Box-RING) superfamily, however, little is known of its function in mammalian systems. To further examine the physiological role, Ariadne 2 deficient mice were generated. In a mixed …
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Functional Interactions Between Par-1b Protein Kinase and RNF41 E3 Ubiquitin Ligase
… associated proteins. Nrdp1/RNF41, a RING finger E3 ligase was identified in their screen along with 14-3-3 and aPKC. I found that Par-1b binds to RNF41 and I identified RNF41 as a novel cell polarity determinant. My work demonstrated that phosphorylation of RNF41 on S254 by Par-1b is necessary …
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Fragment-based approaches to probe the surface of the VHL E3 ligase
… involved in the control of protein homeostasis, E3 ubiquitin ligases are emerging as interesting targets for the development of chemical probes and drugs. Small-molecule modulation of E3 ligases can provide several advantages over other members of the ubiquitin-proteasome system (UPS), as E3 …
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DISSECTING THE ROLE OF NEDD4 HECT E3 LIGASE AND ITS ISOFORMS IN CANCER
NEDD4 is a E3 ubiquitin ligase belonging to the HECT family and is composed by a N-terminal C2 domain, four WW domains and the catalytic C-terminal HECT domain. Different studies evidenced a correlation between NEDD4 overexpression and tumor progression and in some cases its proto-oncogenic …
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Biochemical Characterization of IpaH E3 Ubiquitin Ligase Effector Proteins and Their Host Substrates
… including Salmonella and Yersinia secreted E3 ubiquitin ligases into the host cell cytoplasm via the Type III secretion system (T3SS) apparatus. The invasion plasmid antigen Hs (IpaHs) are a novel family of bacterial E3 ubiquitin ligases that are secreted by Shigella, Salmonella, and …
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