Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"E2F6"”.
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E2F6 in axial skeletal development and gliosis
… dissertation examines the biological role of E2F6 in mammalian development. E2F6 functions as a repressor of transcription in concert with the polycomb group (PcG) proteins and chromatin modifiers. PcG proteins regulate processes required for proper embryonic development and differentiation. …
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The function of E2F6 in the Polycomb complex
… at the G1/S transition. Unlike other E2Fs, E2F6 does not activate transcription and is not regulated by pocket protein binding. Instead, this protein appears to repress transcription through the recruitment of the Polycomb Group (PcG) complex. This complex is responsible for the maintenance …
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Cloning and characterization of E2F6, a novel member of the E2F transcription factor family
… characterization of a novel E2F family member, E2F6. E2F6 bears some sequence homology to the other E2Fs in the DP dimerization and DNA binding domains, but there is a high degree of divergence outside of those domains. Additionally, although the DP dimerization and DNA binding properties of …
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Contrasting Effects of An Mdm2 Functional Polymorphism On Tumor Phenotypes
… database identified transcriptional repressor E2F6 as a possible negative regulator of <em>MDM2</em> expression. Our data show that E2F6 protein is expressed at higher levels in skin keratinocytes of <em>SNP309</em> mice as compared to lymphatic tissues. Furthermore, E2F6 binds and suppresses …
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The role of E2F·pocket protein repressive complexes in cell cycle control and differentiation
… based upon structural and functional homology: E2F6; the 'activating E2Fs' (1-3); and 'the repressive E2Fs' (4-5). The focus of this study is E2F4 and E2F5, the members of the repressive E2F subgroup. The repressive E2Fs function by occupying E2F responsive promoters during Go and recruiting in …
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Investigation of m6A-regulated RNA-binding proteins
N6-methyladenosine (m6A) is one of the most ubiquitous modifications of eukaryotic RNAs. The modifi- cation functions to control the normal processing, export, splicing, and metabolism of cellular RNAs. All of these processes are mediated by a group of m6A RNA-binding proteins known as ‘readers’ …