Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"E2F3"”.
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Crosstalk between E2F3 and p19ARF/p53 in the regulation of cell cycle progression and tumorigenesis
… of the E2F family of transcription factors, E2F3, and the p19ARF/p53 pathway. E2F3 has previously been shown to be critical for cell cycle re-entry, cellular proliferation, and tumor development. The contribution of p19ARF/p53 to E2F3 function was assessed through the generation of compound …
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Genetic and molecular analysis of the E2F transcription factor family in mouse development, tumorigenesis, and cardiac function
… inappropriate release of E2Fs. E2F1, E2F2, and E2F3 are members of the "activating E2F" subfamily that is important for the transcriptional activation of target genes involved in DNA replication and cell cycle control. These E2F family members are essential for cellular proliferation in vitro. …
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Molecular Mechanism of Aurora-A Kinase in Human Oncogenesis
… 1) transcriptional regulation of Aurora-A by E2F3; 2) feedback regulation between tumor suppressor CHFR and Aurora-A; 3) CNTD2 as a novel Aurora-A partner and oncogene to activate Aurora-A and induce transformation. Aurora-A expression and activity are cell cycle regulated. The mechanism of …
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Genomic Characterization of Recurrent Chromosomal Aberrations in Retinoblastoma
… status of KIF14 and MDM4 on 1q and of DEK and E2F3 on 6p. A small subset of retinoblastoma exhibits high-level amplification of the MYCN gene on chromosome 2p and is characterized by pRb expression and aggressive histology. 1p36 deletion is also associated with MYCN amplification in …
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Role of Amplification of Chromosome 6P12-P21 in Human Osteosarcoma
… hybridisation-detected copy number changes in E2F3, PIM1, and RUNX2 and identified trends between increased RUNX2 copy number and poor tumour response to chemotherapy, and between increased E2F3 copy number and CIN. 4) Interphase FISH for chromosome-specific enumeration identified a high rate …
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Genetics of Obesity and Diabetes in the IRAS Family Study
… investigate these linkage regions. Two genes, E2F3 and CDKAL1, on chromosome 6 showed significant associations with subcutaneous adipose tissue (SAT). In E2F3, SNPs rs4710930 and rs6939190, were associated with SAT [Genotypic means: 1/1 (18.62(342)), 1/2 (17.01(142)), 2/2 (17.52(17))]; [1/1 …
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P107 negatively regulates the neural precursor pool by repressing Hes1 transcription
… sites, which were subsequently found to bind E2F3 and E2F4 using chromatin immunoprecipitation. P107 was found to significantly repress Hes1 promoter activity in the luciferase reporter assay, and finally, using the primary neurosphere assay we showed that removal of Hes1 from p107-/- …
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MOLECULAR PROFILING OF UROTHELIAL CARCINOMA
… gene expression profiling and could show that E2F3, CDKAL1, and SOX4 in 6p22, and YWHA (14-3-3) gene family members in 8q22 and 2p25, respectively, are major target oncogenes important for high grade disease.
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Regulation of the Arf tumor suppressor by E2F transcription factors
… specifically repressed by only one E2F isoform, E2F3, and this binding does not fluctuate during cell cycle progression. In response to oncogenic stress, such as expression of the oncoproteins c-Myc or adenovirus E1A, or loss of the tumor suppressors Rb or p53, activating E2F proteins are …
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The E2F1-responsive microRNA-449 promotes apoptosis
… sie die Expression von CDK6, CDK2, E2F1 und E2F3 herunterregulieren. Außerdem reduzieren miR-449 und miR-34 die Expression der Histondeazetylasen SIRT1 und HDAC1. Dabei führen sie zur Aktivierung des p53-Signalwegs und zur Induktion von p21, was in einem verstärkten Zellzyklusarrest in Zellen …
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Study of genetic by environmental interactions at transcriptomic and genomic levels
… among the three GBM events: PIK3R1, E2F3, AKR1C3, CSF1, JAG2, PLCG1, RPL37A, SOD2, TOPORS, HRAS, MDM2, CAMK2G, FSTL1, IL13RA1, MTAP and TP53. Of the genes associated with GBM on a cohort-manner, C2, EGFR, PRKCB, IGF2BP3, and GDF10 had gender-dependent associations; SOX10, RPS20, …
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Single-trace template attacks on permutation-based cryptography
The Template Attack introduced by Chari, Rao, and Rohatgi has been widely used in Side-Channel Attacks on cryptographic algorithms running on microcontrollers. In 2014, Choudary and Kuhn successfully optimized a variant of this technique, based on Linear Discriminant Analysis (LDA), to reconstruct …