Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"E2F1"”.
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The E2F1-responsive microRNA-449 promotes apoptosis
Der Transkriptionsfaktor E2F1 fördert den Eintritt in den Zellzyklus, kann aber auch Apoptose induzieren, vor allem nach Aktivierung durch DNA-Schädigung. Um E2F1-responsive microRNAs zu identifizieren habe ich eine Microarray-Hybridisierung durchgeführt, und fand miR-449a und miR-449b (zusammen …
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E2F1 induction following DNA damage and oncogene activation
The transcription factor E2F1, a critical target of the tumour suppressor pRb, is deregulated in most human cancers. Oncogenes have been shown to deregulate E2F1 through inhibition of pRB and deregulation of E2F1 is an event that occurs in most human cancers. The essential role of E2F1 in apoptosis …
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The Role of E2F1 In The Response to Dna Double Strand Breaks
… and apoptosis are well established. E2F1, but not other E2F family members, is also phosphorylated and stabilized in response to various forms of DNA damage to regulate the expression of cell cycle and pro-apoptotic genes. E2F1 also relocalizes and forms foci at sites of DNA …
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E2F1 and Tumor Suppression: The Role of P21, Mirnas, and The Dna Damage Response
E2F1 is a multi-faceted protein that has roles in a number of important cellular processes including cell cycle regulation, apoptosis, proliferation, and the DNA damage response (DDR). Moreover, E2F1 has opposing roles in tumor development, acting as either a tumor suppressor or an oncogene …
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SOX2 is Associated with Changes in DNA Damage Repair and Cell Cycle Gene Expression and Regulates E2F1
… and transcribes DNA damage repair proteins is E2F1. This thesis found that E2F family gene targets are upregulated in response to increased SOX2 expression and that SOX2 targets the E2F1 promoter. Currently, there are few biomarkers for treatment outcomes in prostate cancer. To address this …
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Differenzielle Regulation und prognostische Bedeutung von zellzyklusassoziierten Regulatoren der G1- und G2-Phase in Abhängigkeit von der anatomischen Lokalisation in Gastrointestinalen Stromatumoren (GIST)
… Proteinexpressionen von den G1-Phase-Proteinen E2F1 und Cyclin D1, sowie von den G2-Phase-Proteinen Cyclin A2 und Cyclin B1 und dem Transkriptionsfaktor Myc wurden in Abhängigkeit von den klinisch-pathologischen Parametern Lokalisation, Morphologie, Tumorgröße, Mitosenanzahl und Mutationsstatus …
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Genetic and molecular analysis of the E2F transcription factor family in mouse development, tumorigenesis, and cardiac function
… through the inappropriate release of E2Fs. E2F1, E2F2, and E2F3 are members of the "activating E2F" subfamily that is important for the transcriptional activation of target genes involved in DNA replication and cell cycle control. These E2F family members are essential for cellular …
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Gene Repression and Cell Cycle Regulation by PU.1 in Acute Myeloid Leukemia
… transplanted mice due to reduced repression of E2F1, leading to deregulation of the cell cycle. Results indicate that NOD/SCID/γc-/- mice transplanted with Sfpi1BN/BN splenocytes become sick with disease resembling AML. Induction of PU.1 expression results in repression of the cell cycle …
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Dissecting the molecular role of distinct binding interfaces on the retinoblastoma tumor suppressor in growth control and tumorigenesis.
… is capable of forming a unique interaction with E2F1 termed the ‘specific’ interaction that is capable of blocking E2F1 induced apoptosis. These functions of pRB are mediated by distinct binding interfaces and their contributions to the overall functionality of pRB are not well defined. In this …
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Unterschiedliche Aktivierung von Signalwegen zur Zellproliferation in mesenchymalen Tumoren des Gastrointestinaltrakts
… der GIST höher war, wurden die höchsten E2F1- und Cyclin-B1-Expressionen bei den Leiomyosarkomen gefunden.SCHLUSSFOLGERUNGEN:Im Vergleich zu Leiomyomen weisen Leiomyosarkome PDGFRA-Expression auf. Für GIST kann eine sequentielle Aktivierung von intrazellulären Signalwegen nachvollzogen …
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Functional characterization of the role of Imp, a Drosophila mRNA binding protein, during oogenesis
… cyclin E (cycE), E2f transcriptional factor 1 (E2f1), lingerer (lig), snail (sna) and mushroom body expressed (mub). E2f1 encodes a transcriptional factor that is involved in regulating the G1 to S phase transition during mitosis. Mutation of E2f1 results in altered grk mRNA and protein …
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The role of the chromatin remodeller ISWI in the cellular response to hypoxia
… of BNIP3 which is dependent on the Rb/E2F1 axis and is rescued by E2F1 knockdown. Importantly, loss of ISWI by siRNA knockdown alters the cellular response to hypoxia by preventing autophagy and inducing apoptosis. These results demonstrate a novel role for ISWI as a survival factor …
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The role of E2F4 in the growth suppressive properties of the retinoblastoma protein
… functional similarities. The activating E2Fs, E2F1, E2F2 and E2F3a, are exclusively regulated by pRB and are primarily involved in activating the transcription of E2F-responsive genes that are required for cell cycle progression. The repressive E2Fs, E2F3b, E2F4 and E2F5, are regulated by the …
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Cloning and characterization of E2F6, a novel member of the E2F transcription factor family
… E2F group can be subdivided into two subclasses (E2F1, 2, 3 versus E2F4 and 5). The work detailed in this study focuses on the cloning and characterization of a novel E2F family member, E2F6. E2F6 bears some sequence homology to the other E2Fs in the DP dimerization and DNA binding domains, but …
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Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression
… facilitates genome stability suggests that a pRB-E2F1-Condensin II complex localizes to pericentromeric heterochromatin. In the absence of this complex, DNA double strand breaks are observed and persist into mitosis and the ensuing G1 phase of the cell division cycle. Moreover, haploinsufficiency …
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MicroRNAs: Tissue Expression and Role in 3T3-L1 Pre-Adipocyte Differentiation
… 3T3-L1 adipogenesis. Knock-down of Hmga2 or E2f1 by siRNA inhibited 3T3-L1 pre-adipocyte differentiation. Our results suggest let-7 can stop clonal expansion of 3T3-L1 cells and bring them to final growth arrest and terminal differentiation by targeting Hmga2. In an effort to explore the role …
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Analysis of the Role of the Transcription Factor-C/ebpbeta in Implantation
… cell cycle regulators such as cyclin E and E2F1. My studies, using a siRNA strategy, revealed that C/EBPbeta also plays an essential role in human stromal differentiation. We employed microarray analysis to establish that several factors, such as BMP2, Wnt4, IL11Ra, and STAT3, are downstream …
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Analysis of the role of the transcription factor-C/EBPβ in implantation
… cell cycle regulators such as cyclin E and E2F1. My studies, using a siRNA strategy, revealed that C/EBPβ also plays an essential role in human stromal differentiation. We employed microarray analysis to establish that several factors, such as BMP2, Wnt4, IL11Ra, and STAT3, are downstream …
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Cell Cycle Regulation by Post-Translational and Post-Transcriptional Mechanisms in an Anaerobic Extremist- the Anoxia Tolerant Turtle, Trachemys Scripta Elegans
… that both kidney and liver establish an Rb/E2F1 mediated G1 arrest complex by 5 and 20 h anoxia, repectively. By 20 h anoxia, kidney tissue established a reversible state of G0, characterized by the prescence of a p130/E2F4 DNA-bound complex.Overall, results from this thesis indicate that …
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