Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"E2F Transcription Factors"”.
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Regulation of the Arf tumor suppressor by E2F transcription factors
… of two major signaling pathways, the pRB-E2F growth-control pathway and the p53 stress-response pathway. Members of the E2F family of transcription factors are key downstream targets of the retinoblastoma protein, pRB, and mediate the activation of genes required for cellular …
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Dissecting the molecular role of distinct binding interfaces on the retinoblastoma tumor suppressor in growth control and tumorigenesis.
… to tumorigenesis. pRB is capable of regulating E2F transcription factors to mediate control of proliferation through transcriptional regulation of S-phase target gene expression. In addition, pRB can stabilize the CDK inhibitor p27 through an interaction with two ubiquitin ligase complexes. …
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Identification and Characterization of EFL-3, a C. Elegans E2F Transcription Factor
… through the cooperative efforts of Hox and E2F proteins. E2F transcription factors are critical, conserved regulators of the cell cycle and apoptosis. However, little is known about the two most recently discovered mammalian E2Fs—-E2F7 and E2F8. In the nematode Caenorhabditis elegans, we …
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The roles of Rb, p107, and E2f4 in bone formation and embryonic development
… proteins, through their interaction with the E2F transcription factors, ensure the proper regulation of cell proliferation. By doing so, these protein complexes affect other fundamental processes such as differentiation. Here we analyze the in vivo roles of three proteins, pRb, E2F4, and p107, …
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Regulation mechanisms of Drosophila retinoblastoma protein stability and repression activity
… retinoblastoma (RB) family proteins are pivotal transcriptional corepressors involved in diverse cellular events. As a potent tumor suppressor, RB plays a variety of important roles including regulating cell cycle, promoting cellular differentiation, inducing cell senescence and balancing …
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The role of E2F4 in the growth suppressive properties of the retinoblastoma protein
… mediated through the repression of the E2F transcription factors. Functional inactivation of pRB, and subsequent deregulation of E2F activity, is a critical event in the formation of most human cancers. pRB is a member of the pocket protein family, which includes p107 and p130. The …
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E2F6 in axial skeletal development and gliosis
E2F transcription factors were originally identified as regulators of cell cycle and cellular proliferation. In vivo mouse models have uncovered novel roles for these proteins in different developmental processes. This dissertation examines the biological role of E2F6 in mammalian development. E2F6 …
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Genetic and molecular analysis of the E2F transcription factor family in mouse development, tumorigenesis, and cardiac function
The E2F transcription factors are critical downstream targets of the retinoblastoma protein (pRB) pathway. A component of the pRB pathway is mutated in most human tumors resulting in deregulation of cell cycle control through the inappropriate release of E2Fs. E2F1, E2F2, and E2F3 are members of …
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The Role of E2F1 In The Response to Dna Double Strand Breaks
<p>The importance of E2F transcription factors in the processes of proliferation and apoptosis are well established. E2F1, but not other E2F family members, is also phosphorylated and stabilized in response to various forms of DNA damage to regulate the expression of cell cycle and pro-apoptotic …
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The B55α/PP2A Holoenzyme in Cell Cycle Exit, Maturation/Differentiation, and Cancer
… state, they are associated with E2F transcription factors which result in the repression of transcription of E2F-dependent genes that are required for cell cycle progression. The phosphorylation state of pocket proteins during the cell cycle is determined at least in part by an …
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Repression of E2F-4 Mediated Transcription and Growth by Hypophosphorylated pRb2/p130 in Human Prostate Cancer Cells
… RB proteins bind to and modulate the activity of E2F transcription factors, by way of a unique binding motif termed the pocket domain; as such, RB family genes are often referred to as pocket proteins. E2F -1, -2, and -3 are considered transcriptional activators and have been shown mainly to bind …