Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"E2F"”.
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Regulation of the Arf tumor suppressor by E2F transcription factors
… of two major signaling pathways, the pRB-E2F growth-control pathway and the p53 stress-response pathway. Members of the E2F family of transcription factors are key downstream targets of the retinoblastoma protein, pRB, and mediate the activation of genes required for cellular …
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Identification and Characterization of EFL-3, a C. Elegans E2F Transcription Factor
… through the cooperative efforts of Hox and E2F proteins. E2F transcription factors are critical, conserved regulators of the cell cycle and apoptosis. However, little is known about the two most recently discovered mammalian E2Fs—-E2F7 and E2F8. In the nematode Caenorhabditis elegans, we …
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Molecular analysis of the role of E2F proteins in the pRB pathway
The E2F family of transcription factors appear to represent the primary cellular target of the tumor suppressive properties of the retinoblastoma protein. E2F therefore functions in a pathway which is a frequent target in human cancer, and the tumorigenicity of these mutations may be mediated at …
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Cloning and characterization of E2F6, a novel member of the E2F transcription factor family
The E2F family of proteins plays a critical role in the regulation of genes that are essential for progression through the cell-cycle. Based upon sequence homology and functional properties, the E2F group can be subdivided into two subclasses (E2F1, 2, 3 versus E2F4 and 5). The work detailed in …
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Repression of E2F-4 Mediated Transcription and Growth by Hypophosphorylated pRb2/p130 in Human Prostate Cancer Cells
… RB proteins bind to and modulate the activity of E2F transcription factors, by way of a unique binding motif termed the pocket domain; as such, RB family genes are often referred to as pocket proteins. E2F -1, -2, and -3 are considered transcriptional activators and have been shown mainly to bind …
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Integrative Analysis of the Myc and E2F pathway Reveal the Roles for microRNAs in Cell Fate Control
… of tumorigenic process. With Myc and E2F pathways being central components for controlling cell proliferation, an important property that defines a cancer cell, as well as expanding roles for microRNAs(miRNA) in control of gene expression, we asked if we may better understand the …
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Genetic and molecular analysis of the E2F transcription factor family in mouse development, tumorigenesis, and cardiac function
The E2F transcription factors are critical downstream targets of the retinoblastoma protein (pRB) pathway. A component of the pRB pathway is mutated in most human tumors resulting in deregulation of cell cycle control through the inappropriate release of E2Fs. E2F1, E2F2, and E2F3 are members of …
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DNA-binding specificity of the E2F gene family, and cloning and characterization of a novel family mamber
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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Crosstalk between E2F3 and p19ARF/p53 in the regulation of cell cycle progression and tumorigenesis
E2F activity was originally identified as a critical component of the cellular machinery responsible for promoting cell cycle progression that is co-opted during transformation and tumorigenesis. Classic E2F target genes have functions required for S-phase entry and progression. However, the role …
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Drosophila E2F and DP genes : their role in the regulation of G1-S progression and the activity of DNA replication origins
… are in the Drosophila homologs to the mammalian E2F and DP genes. The E2F transcription factor, a heterodimer of E2F and DP subunits, is linked to the G1-S transition in mammalian cells. Five mutations in the Drosophila DP gene (dDP) were isolated and provide the first opportunity to examine the …
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The role of E2F·pocket protein repressive complexes in cell cycle control and differentiation
… with their major downstream target, the E2F transcription factor. E2F is a heterodimeric protein composed of one DP subunit and one E2F subunit. The E2F family can be subdivided into three categories based upon structural and functional homology: E2F6; the 'activating E2Fs' (1-3); and …
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The Animal-fungi Hybrid Cell Cycle of the Zoosporic Fungus Spizellomyces punctatus - a New Model to Understand Evolution of Eukaryotic Cell Cycle Control
… that control commitment to cell division (E2F and SBF, respectively) and their repressors (Rb and Whi5, respectively) do not appear to have a shared molecular origin. My thesis work has focused on understanding how the networks that regulate cell cycle decisions have changed and rewired …
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The role of E2F4 in the growth suppressive properties of the retinoblastoma protein
… mediated through the repression of the E2F transcription factors. Functional inactivation of pRB, and subsequent deregulation of E2F activity, is a critical event in the formation of most human cancers. pRB is a member of the pocket protein family, which includes p107 and p130. The …
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Complex Regulation of Pax6 Neuronal Progenitors By Rb Family Members During Corticogenesis
… cell cycle progression via repression of the E2F transcription factor family and by promoting cell differentiation via activation of lineage-specific transcription factors. In contrast, the closely related pRB homologues, p107 and p130, are known to inhibit cell cycle progression by repressing …
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Mechanisms of Cytokine-Induced IGF -I Insensitivity in Cancer Cells
… (IRS-1), to induce accumulation of both E2F-1 and cyclin A, to hyperphosphorylate retinoblastoma (RB), and to induce enzymatic activity and association of Cdk2 with cyclin A. The cytostatic property of these cytokines was also shown by their ability to block IGF-I-stimulated luciferase …
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Dissecting the molecular role of distinct binding interfaces on the retinoblastoma tumor suppressor in growth control and tumorigenesis.
… to tumorigenesis. pRB is capable of regulating E2F transcription factors to mediate control of proliferation through transcriptional regulation of S-phase target gene expression. In addition, pRB can stabilize the CDK inhibitor p27 through an interaction with two ubiquitin ligase complexes. …
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The roles of the retinoic acid receptors in growth, differentiation and development.
… growth signals within the cell. I found that E2F, a transcription factor which induces cell cycle progression, is able to specifically inhibit the actions of the RARs in activating transcription. My data indicates that this is due to E2F squelching of factors from RAR transcription complexes. …
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P107 negatively regulates the neural precursor pool by repressing Hes1 transcription
… of the Hes1 promoter revealed three putative E2F binding sites, which were subsequently found to bind E2F3 and E2F4 using chromatin immunoprecipitation. P107 was found to significantly repress Hes1 promoter activity in the luciferase reporter assay, and finally, using the primary neurosphere …
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The role of E2f4 in cell cycle exit and bone development
Members of the E2F family of transcription factors are critical downstream effectors of the pocket protein family and mediate the regulation of genes required for cellular proliferation. The repressive E2Fs act in association with the pocket proteins to promote a G0/G1 phase of the cell cycle. …
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The Role of E2F1 In The Response to Dna Double Strand Breaks
<p>The importance of E2F transcription factors in the processes of proliferation and apoptosis are well established. E2F1, but not other E2F family members, is also phosphorylated and stabilized in response to various forms of DNA damage to regulate the expression of cell cycle and pro-apoptotic …
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