Global ETD Search
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Showing 1 to 20 of 593 for “"E2"”.
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Einschränkung hepatischer Abwehrreaktionen während einer Entzündung durch Prostaglandin E2 über Gs-Protein-gekoppelte Prostaglandin E2-Rezeptoren
… des EP2-R und EP4-R induzieren, wodurch PGE2 cAMP-abhängig die IL-6-stimulierte Bildung des Haupt-Akutphase-Proteins der Ratte, des alpha2-Makroglobulin, durch eine Verringerung der Aktivität des Transkriptionsfaktors STAT3 hemmen konnte. In Kupfferzellen der Ratte und der Maus konnten …
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Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex: e1 and e2 substrate specificty, e1 carboligase activity, and e2 interchain succinyl transfer
… (E1 o), a di hydrol i poylsucci nyl transferase (E2o), and a di hydrol i poyl dehydrogenase (E3). The first two components carry out the principal reactions for succinyl CoA formation while the third one reoxidizes dihydrolipoamide to lipoamide. This mechanism is similar to other 2-oxoacid …
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Modulation der Insulinsignalgebung durch Prostaglandin E2 und Endocannabinoide
… Antwort auf dieses Entzündungsgeschehen wird PGE2 unter anderem von Kupffer Zellen der Leber freigesetzt und kann seine Wirkung über vier PGE2-Rezeptorsubtypen (EP1-EP4) vermitteln. In vorangegangenen Arbeiten konnte gezeigt werden, dass PGE2 in Rattenhepatozyten über den EP3 R ERK1/2-abhängig …
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Transcriptional Regulation Mediated by Human Papillomavirus E2 Protein
… expression is mainly controlled by virus-encoded E2 proteins which act as sequence-specific DNA-binding proteins in concert with host cellular transcription factors. Using reconstituted cell-free transcription systems, cellular enhancer-binding factors and general cofactors, such as TAFIIs, TFIIA, …
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Studies on the Mechanism of Colicin E2 Killing
Made available in DSpace on 2014-12-14T04:27:39Z (GMT). No. of bitstreams: 1 7726719.pdf: 4840555 bytes, checksum: f139ca501ed8506cf62aee590714ad30 (MD5) Previous issue date: 1977
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Novel Insights into Ubiquitin-like Protein E1-E2 Interactions
… by a series of molecular handoffs down an E1‑E2‑E3 cascade. We are interested in understanding how E1‑E2 pairs interact and mediate UBL transfer. To this effect, we studied two E1‑E2 pairs: the Sumo pathway (Sumo utilizes a canonical E1 and E2) and the Atg8 pathway (Atg8 is a UBL involved in …
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Localization of Human Prostaglandin E2 Receptors in Polarized Epithelial Cells
… localization of the human prostaglandin E2 receptors. The EP receptors are all GPCRs, which differ in their second messenger pathways. The EP3 receptor is unique in that it has eight different isoforms that differ in the lengths of the carboxyl tail. The EP3 isoforms, as well as the EP2 …
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Multiple Functions of BRD4 in E2 Mediated HPV Transciptional Regulation
… and E7 oncoproteins is controlled by the viral E2 protein, which plays a dual role in gene activation and repression. Recently, we identified bromodomain-containing protein 4 (Brd4) as a cellular corepressor for E2-mediated inhibition of HPV transcription. Brd4 contains two bromodomains which …
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Targeting Prostaglandin E2 Receptor EP2 for Treatment of High-Risk Neuroblastoma
<p>Prostaglandin E2 (PGE2) is a predominant proinflammatory regulator that plays pivotal roles in regulating tumor cell proliferation, migration, and invasion. It fosters an inflammation-enriched microenvironment that facilitates angiogenesis and immune evasion. Neuroblastoma (NB) is a lethal …
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A Gain-of-Function Role of Apolipoprotein E2 in Melanoma Progression
… and responses to immunotherapy. Conversely, APOE2 allele carriers experience substantially worsened survival outcomes compared to APOE4 carriers and APOE3 homozygotes. These survival differences are partly governed by effects on the immune system, as the APOE4 genotype augments anti-tumor …
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Conserved Residues in Murine Papillomavirus E2 Regulate the Viral Life Cycle
… is post-translational modification on the viral E2 protein, which is responsible for orchestrating viral transcription, replication, and genome partitioning. The hypothesis underscoring this work is that residues in E2 are highly conserved across PV types because they serve some structural or …
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Studies on the Role of Endonuclease-I in Colicin-E2 Killing
Made available in DSpace on 2014-12-10T23:24:28Z (GMT). No. of bitstreams: 1 7317101.pdf: 4847136 bytes, checksum: 539972cf25e874c3aa928980fa00fafa (MD5) Previous issue date: 1972
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… play a key role in synthesising prostaglandin E2 (PGE2) from arachidonic acid. PGE2 has been implicated in preclinical stages of Alzheimer’s disease, where elevated levels of PGE2 in the cerebrospinal fluid can be found, as well as aberrant amyloid processing in experimental models of disease. …
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Functional Interactions of E2~Ubiquitin Conjugates in and outside the Ubiquitination Pathway
… Ub transfer pathway are well established (E1, E2, E3), the molecular details required for protein ubiquitination are largely unknown. To address questions regarding the final stages of Ub transfer, we began with structural characterization of the pathway intermediate, the E2~Ub conjugate (~ …
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