Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"E1A"”.
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Untersuchungen zum Transfer von E1A-deletierten Adenoviren in vielfachresistenten Tumorzellen durch Magnetofektion
… Sehr viel versprechend ist die Entdeckung von E1A-deletierten Adenoviren, die in vielfachresistenten Tumorzellen, welche häufig den humanen Transkriptionsfaktor YB-1 im Kern enthalten, eine E1A-unabhängige adenovirale Replikation und virale Tumorzelllyse durchführen können. In der vorliegenden …
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The Interaction of the Human Adenovirus E1A Protein with the Human DREF Transcription Factor
The human adenovirus (HAdV) E1A protein is the first protein produced post-HAdV infection, and serves two main functions. The first is to modulate host and viral transcription. The second is to induce host cell cycle progression to S phase, to promote an optimal environment for viral replication. …
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E2F1 induction following DNA damage and oncogene activation
… Cells expressing the adenovirus early region 1A (E1A) oncogene have been used as a tool to identify cellular regulatory pathways that modulate chemosensitivity. E1A sensitises cells to the induction of apoptosis by diverse stimuli, including many chemotherapeutic drugs. These E1A activities are …
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p53 activity during adenovirus infection
… Wir fanden weiterhin, dass das adenovirale E1A Protein die p53 Aktivität in der Abwesenheit von E1B-55kDa hemmt. Dabei inhibieren zwei Regionen des E1A Genprodukts unabhängig voneinander die p53 Aktivität. Weiterhin ist der E1B-defiziente Virus nur in Abhängigkeit von der konservierten …
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Control of major histocompatibility Class I antigen expression in adenovirus transformed cells.
… in cells expressing Adenovirus (Ad) 12 E1A compared to cells expressing E1A from Ad2 or Ad5. The possible involvement of these sequences and the factors that bind to them in this down-regulation was investigated using transient expression assays and in the case of CRE1, also by gel …
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Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer
… a panel of oncolytic adenovirus vectors with the E1A CR2 24 deletion and the E1A promoter replaced by an insulated E2F-1 promoter. The latest two in this series of vectors, termed ICOVIR-5 and ICOVIR-7, provide potential oncolytic backbones for the introduction of the therapeutic transgene …
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Inhibierung von Adenovirusinfektion mittels siRNA vermittelter Blockade adenoviraler Regulations- und Verpackungsgene
… Typ 5 durch siRNAs gegen die adenoviralen Gene E1A, Hexon und IVa2 inhibieren lässt. Initial wurde dazu unter vier verschiedenen gegen jedes Zielgen vorliegenden synthetischen siRNAs die effizienteste evaluiert und weiteren Analysen zugeführt. Die sequenzspezifische Wirkung der siRNAs konnte in …
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The contribution of competence system to the virulence of Streptococcus pneumoniae
… I demonstrate that one of the CSP analogs, CSP1-E1A, competitively inhibits the ability of CSP1 to induce genetic transformation in a concentration dependent manner. I also demonstrate that CSP1-E1A successfully attenuates the expression of two virulence factors, CbpD and LytA during competence …
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Enzyme Linked Immunological Studies of Cholinesterases in Human Blood
… both activity and antigen levels for E1u E1u, E1uE1a and E1aE1a individuals. The approximate amount that each of the genes E1a , E1a and E1f contribute to the ChE activity and antigen levels is presented allowing the effective efficiency (EE) of the gene product to be calculated. Immunological …
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Identifizierung und funktionelle Charakterisierung des Spleißfaktors SRp30c als Interaktionspartner des Y-box-Proteins-1 (YB-1)
… for in vivo splicing is demonstrated in the E1A minigene model system. Here, changes in splice site selection are detected, that is, overexpression of YB-1 is accompanied by preferential 5' splicing site selection and formation of the 12 S isoform.
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Investigation of the p53-dependent apoptosis versus arrest decision through analysis of Prep gene regulation
… p53-dependent apoptosis by the oncoprotein E1A. Through a subtractive hybridization screen, the Perp gene was identified as a transcript strongly upregulated in cells initiating p53-dependent apoptosis compared to those undergoing cell cycle arrest.
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Regulation of the Arf tumor suppressor by E2F transcription factors
… of the oncoproteins c-Myc or adenovirus E1A, or loss of the tumor suppressors Rb or p53, activating E2F proteins are recruited to Arf and transcription of the gene is induced. In normal mouse tissues Arf is not expressed, yet E2F does not participate in its repression. Arf is only …
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Creg1 And Its Enhancement Of P16ink4a-Induced Senescence
… we found that CREG1 (Cellular Repressor of E1A-stimulated Genes1) is one of genes whose expression fit the criteria of senescence-associated genes, decreased expression during immortalization and increased in senescence. Moreover, we found that epigenetic mechanisms regulate CREG1 expression …
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Kinetics and Mechanisms of Human Adenovirus 2 Inactivation With UV and Chlorine
… replication, a step prior to the synthesis of E1A. My extensive characterization of the effects of pH and temperature show that monochloramine accomplishes less inactivation of adenoviruses in conditions of high pH and/or low temperature. My tests also show that sequential treatments of either …
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Propriétés de divers antigenes grand T mutants du virus polyome
… une grande homologie avec le domaine 2 de E1A d'adénovirus impliqué dans la liaison à la protéine RB (produit du gène de la susceptibilité au rétinoblastome). Il existe une étroite corrélation entre la capacité de lier RB et celle de transformer pour SV40 et adénovirus. Nous avons montré …
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Structure–Activity Analysis of Peptide-Mediated Quorum Sensing in Streptococcus mitis
… that the Glu1-to-Ala analog (S. mitis-CSP1-E1A) acted as an activator in S. mitis NCTC 8033, whereas the same Glu1-to-Ala substitution in CSPs from other Streptococcus species, as well as in a different S. mitis pherotype producing and responding to S. mitis-CSP2, has been reported to …
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Comparative study of the kinetics and mechanisms of adenovirus and bacteriophage PR772 inactivation by disinfectants used for global safe drinking water
… synthesis as well as late hexon mRNA and early E1A mRNA transcription were inhibited. When exposed to free chlorine, PR772 had remarkably similar inactivation kinetics compared to HAdV-2. Like HAdV-2, free chlorine inactivated PR772 could still bind to host cells but genome replication and mRNA …
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Studies on a novel poly(ADP-ribosyl)ation polymerase PARP-10 and its functional interaction with c-Myc
… transactivation and inhibit c-Myc/Ha-Ras- and E1A/Ha-Ras-dependent transformation indicating that PARP-10 might repress c-Myc function in target gene regulation and oncogenesis. In summary, this study suggests that PARP-10 is a novel PARP enzyme that interacts with the proto-oncoprotein c-Myc. …
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Studies of the Molecular Features of Brd4-Nut and P300 That Contribute to Condensate Formation and Transcriptional Regulation
Aberrant formation of biomolecular condensates has been proposed to play a role in several cancers. The oncogenic fusion protein Brd4-Nut drives aberrant gene expression and forms condensates in Nut Carcinoma (NC). It has not been clear how these condensates form and whether they modulate gene …