Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"E-selectin"”.
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Molecular Mechanisms of Circulating Tumor Cell Adhesion in Breast Cancer Metastasis
… is mediated by interaction of endothelial E-selectin with its counter-receptor(s) expressed on breast cancer cells. This hypothesis was tested by using a variety of specialized biochemical techniques and tumor cell/endothelial cell adhesion assays. It was found that breast cancer cells …
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Functional Significance of the Upregulation of Adhesion Molecules on Irradiated Endothelial Cells
… molecules mediate this process, particularly, E-selectin and ICAM-1, which are inducible adhesion molecules. E-selectin is involved in the initial tethering and rolling steps of the adhesion cascade while ICAM-1 appears to be involved in the latter steps. We have hypothesized that in response to …
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Targeted Multistage Delivery of Nanoparticles to The Bone Marrow
… while decreasing exposure to normal tissues. E-selectin is constitutively expressed on the bone marrow vasculature, but almost absent in normal vessels, and therefore, E-selectin targeted drug delivery presents an ideal strategy for the delivery of therapeutic nanoparticles to the bone …
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Effect of Monounsaturated Fat Rich Almonds on Hemostatic and Inflammatory Factors in Healthy Adults
… of inflammation including C-reactive protein, E-selectin and interleukin-6 have been proposed to be newer risk factors for cardiovascular disease. However, the influence of nuts such as almonds on markers of inflammation and hemostasis that influence cardiovascular disease risk is not currently …
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Effects of Linoleic Acid on Tether Formation between Monocytes and Endothelial Cells
… Tether extraction occurred primarily through E-selectin. Treatment with free linoleic acid increased the localization of E-selectin to clathrin-coated pits suggesting an increase in the formation of nanoclusters of E-selectin on HUVECs. The increase in tether frequency was blocked by the U73122 …
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Influence of the Atrial Natriuretic Peptide on TNF- αα α -activated human endothelial cells
… of adhesion molecules (ICAM-1, VCAM-1, E-selectin), chemokines (MCP-1), and cytoskeleton changes in human endothelial cells. 5.1.1 Effect of ANP on TNF- α αα-induced CAM expression The following diagram shows a schematic outdraw of the summerized results of the first part of the present …
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On the role of mast cells in chemokine-induced leukocyte recruitment
… can activate endothelial cells to express P-selectin and CXC chemokine (MIP-2) and cause leukocyte adhesion in vitro in a glucocorticoid-sensitive manner. Interestingly, chemokines, both MIP-Ialpha, MCP-I and MIP-2, KC, were found to provoke a dose-dependent increase in P-selectin-dependent …
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Fatty acid regulation of adhesion molecule expression in human vascular cells.
… vascular cell adhesion molecule-1 (VCAM-1) and E-selectin are expressed on endothelial cells and lymphocyte function-associated antigen-1 (LFA-1), very late antigen-4 (VLA-4), are expressed on the leukocytes. The consumption of n-3 polyunsaturated fatty acids (PUFA) from fish and fish oil have …
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Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study
… cell adhesion molecule-1 (sVCAM-1), and E-selectin, as markers of endothelial dysfunction. The plasma glucose to vitamin C ratios were also calculated. Daily clinical measures in the patients included Sequential Organ Failure Assessment (SOFA) score, mean arterial blood pressure, blood …
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Effect of Obesity on the Traditional and Emerging Cardiovascular Disease Risk Factors in African American Women
… plasminogen activator inhibitor-1 [PAI-1], E-selectin, quantitative insulin sensitivity check index [QUICKI], and soluble intercellular adhesion molecule-1 [sICAM-1]). Prediabetes and diabetes were determined based on the American Diabetes Association criteria. Normal values for lipids were …
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Immunological responses following surgery in ulcerative colitis
… cell adhesion molecules, ICAM-1 and E-Selectin, but not VCAM-1, were found to be useful markers of disease activity in UC. Plasma levels of cytokines do not reflect disease activity, however, there is similar quantitative expression of pro-inflammatory cytokines by isolated mucosal …
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Development of a direct photochemical method for the generation of biomolecular interfaces for applications in leukocyte biology
… studies. Substrates tailored to present P-selectin or E-selectin, which are proteins expressed on the inflamed endothelium, were applied to flow assays with neutrophils isolated from whole blood for investigating the effects of bromelain, an alternative anti-inflammatory treatment, on …
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The role of NK cells in selectin-dependent tumor suppression
Selectins are a small family of adhesion molecules that are critical for immune cell trafficking. In our laboratory, mice lacking all combinations of selectins have been generated. Previous work from our laboratory has demonstrated that, in the absence of selectins, human tumors transplanted …
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Fine Particulate Matter, Neuropathologies, & Dementia
… exposure and biomarkers of vascular injury (E-selectin, vascular cell adhesion molecule-1 (VCAM-1)) in the cerebrospinal fluid (CSF). This question is important to investigate because of the growing evidence of the role of cerebrovascular disease in dementia as well as well-established linkages …
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The Effects of Long Term Walnut Consumption on Levels of Plasma Tocopherols and Inflammatory Mediators
… was no significant change in any of the plasma e-selectin and TNF-a level. However, IL-1β and IL-6 were significantly decreased during the walnuts supplemented diet (p < 0.05). In conclusion, the addition of walnuts for 12% of daily energy intake into the diet did not increase plasma y-tocopherol, …
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The Role of Glycoconjugates in Mediating Human Fertilization and Induction of Fetomaternal Tolerance
… inhibit immune cell interactions mediated by the selectins, potently block human sperm-egg binding. The selectin ligand sialyl Lewis<sup>x</sup> inhibits sperm binding in the HZA by 60% at a concentration of 1 mg/ml. Our data indicates that glycodelin-A, a endometrial glycoprotein known to block …
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Targeting brain inflammation with bioconjugated nanoparticles
… monocyte chemotactic protein-1 (MCP-1), E-selectin, and intercellular adhesion molecule-1 (ICAM-1) displayed significant overexpression when compared to the control. Additionally, folate receptor-α (FR-α) was also overexpressed, confirming that our model will function appropriately for …
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Characterization of the biochemical and biophysical mechanisms fundamental to receptor-mediated white blood cell accumulation.
… leukocyte-leukocyte interactions mediated by L-selectin and PSGL-1 enhance accumulation of cells. We have recreated these initial cell recruitment events in vitro using simplified systems. We have identified a novel mechanism that enables cell-cell interactions to occur which may contribute in …
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Mechanisms responsible for homocysteine mediated damage to human endothelial cells : the role of oxidative stress in atherogenesis.
… which in turn mediated up-regulation of E-selectin, ICAM-1 and to lesser extent P-selectin. Furthermore, DL-Hcy induced production of IL-8 protein. These CAM and chemokines collectively mediated different interactions between DL-Hcy-treated HUVEC and neutrophils under flow conditions …
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