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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 152 for “"E-cadherin"”.

  1. E-cadherin mechanotransduction beyond cell-cell junctions

    Muhamed, IsmaeelUniversity of Illinois at Urbana-Champaign2016

    Cadherins and integrin receptors form crucial extracellular adhesive connections with, respectively, adjacent cells and the extracellular matrix, and transduce mechanical signals across cell membranes. The role of adhesive complexes in diseases, cardiomyopathies, atherosclerosis, cancer, stem cell …

    uiuc Repository record

  2. Expression of E-cadherin and HGF in Hypopharyngeal Cancer

    이, 장우2011

    … cancer which has relatively poor prognosis. E-cadherin is a large family of Calcium dependent intercelluar Adhesion Molecule(CAM) whose functions are essential for the induction and maintenance of intercellular cohesion and hepatocyte growth factor(HGF), a potent stimulator of hepatocyte …

    ajou Repository record

  3. Mechanism of E-cadherin dimerization at the plasma membrane

    Vu, VinhUniversity of Illinois at Urbana-Champaign2021

    Embargo set by: Seth Robbins for item 118623 Lift date: 2023-09-17T04:04:53Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system

    uiuc Repository record

  4. INVESTIGATING ALTERNATIVE SPLICING REPROGRAMMING REGULATED BY THE E-CADHERIN/B-CATENIN AXIS

    MAESTRINI, GIORGIAUniversità degli Studi di Milano2024

    … behind this dysregulation, pinpointing E-cadherin and β-catenin as central players in myosin VI AS regulation. β-catenin's nuclear translocation induces myosin VIshort expression, while its depletion rescues myosin VIlong. Furthermore, we uncovered β-catenin's broader involvement in AS …

    milano Repository record

  5. Epidermal growth factor receptor is an essential component in E-cadherin force-transduction complexes

    Zou, YuboUniversity of Illinois Urbana-Champaign2025

    … on the structural functional analysis of E-cadherin and EGFR interaction and their role in mediating E-cadherin mechanotransduction. E-cadherin serves as molecular Velcro in epithelial cells to maintain epithelial homeostasis. Despite passively bearing mechanical stress at cell-cell …

    uiuc Repository record

  6. Role of e-cadherin in tumor metastasis and discovery of compounds targeting metastasis cancer cells

    Onder, Tamer TMassachusetts Institute of Technology2008

    The epithelial cell adhesion molecule E-cadherin is often downregulated during carcinoma progression and metastatic spread of tumors. However, the precise mechanism and molecular basis of metastasis promotion by E-cadherin loss is not completely understood. To investigate its role in metastasis, I …

    mit Repository record

  7. Die Expression von E-Cadherin in der Embryonalentwicklung der Maus : Analyse von cis-aktiven regulatorischen Elementen

    Stemmler, Marc

    Korrekte Regulation der Transkription des E-Cadheringens zur Etablierung von homophiler Zell-Adhäsion ist notwendig für einwandfreie frühe Embryonalentwicklung und Organogenese. Trotz der Bedeutung von E-Cadherin bei der Embryogenese, im intakten Organismus, sowie der veränderten Expression bei der …

    freiburg-diss Repository record

  8. Μελέτη της E-cadherin σε δείγματα καρκίνου μαστού και του σύστοιχου λεμφαδένα: ο ρόλος στη μετάσταση

    Μηνούδη Ευδοκία, Minoudi Evdokia2026

    … ρύθμιση της μετάστασης είναι η έκφραση της E-cadherin. Αν και έχει περιγραφεί ως βασικό μόριο επιθηλιακών διακυτταρικών συνδέσεων, με τη μείωση της έκφρασής της να επιτρέπει στα καρκινικά κύτταρα να διαφεύγουν και να μεταναστεύουν, εντούτοις η παρουσία της είναι απαραίτητη για τη διατήρηση των …

    athens Repository record

  9. Role of shNDPK and E-Cadherin in Growth and Metastasis of an Inflammatory Breast Cancer Model (MARY-X)

    Belcher, Meagan L.University of Nevada, Reno2011

    … by inducing endothelial cell proliferation. E-Cadherin, an adherence protein, is overexpressed in MARY-X spheroids and is responsible for the densely aggregated configuration and the stem cell-like nature of the in vivo emboli and the in vitro spheroids. We will also investigate specific …

    unr Repository record

  10. Kollagen Typ I induziert die Phosphorylierung von Cateninen und die Dissoziation des E-Cadherin-Catenin-Komplexes in Pankreaskarzinomzelllinien.

    Müller, ClaudiaUniversität Ulm

    ulm-diss Repository record

  11. Systemic Leptin Modulates the Expression of E-cadherin, β-catenin in the Ovary of Dietary-Induced Obese Infertile Rats

    Sokan, Olufunke A2013

    … is poorly understood. Recent evidence indicates Ecadherin/ β-catenin complex, which is a structural constituent of adherens junction, is expressed in the rat ovary during folliculogenesis. We hypothesized that systemic leptin modulates the expression of E-cadherin and β-catenin in dietary-induced …

    etsu Repository record

  12. Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape

    Jaca, AnelisaDepartment of Clinical Laboratory Sciences2013

    … factors. Amongst the genetic factors, the E-cadherin (CDH1) gene is said to play a major role in the development of gastric cancer. Both germline and somatic mutations have been identified in the CDH1 gene. The germline mutations span the entire exon of this gene and are seen in approximately …

    cape-town Repository record

  13. The regulation of LIV-1 mRNA in MDA-MB-231 human breast cancer cells and its association with E-cadherin (CDH1)

    Chong, Leelyn2011

    … the expression of the cell adhesion protein, E-cadherin (CDH1), thought to play a role in metastasis. In the present study, we investigated the regulation of LIV-1 and its relationship to CDH1 in MDA-MB-231 ER<sup>-</sup> breast cancer cells. Cells were treated with insulin and EGF for 24 hours …

    uconn-diss Repository record

  14. A morphologic and immunohistochemical analysis of gastric adenocarcinoma with regard to the presence of E-cadherin and localisation of β-catenin staining

    Roberts, RiyaadhDivision of Anatomical Pathology2014

    Includes abstract. Includes bibliographical references.

    cape-town Repository record

  15. TGF-B1 reduces the immunosurveillance of the cervical transformation zone by affecting the E-cadherin mediated interactions between Langerhans cells and metaplastic keratinocytes

    Herfs, MichaelULiège - Université de Liège2007

    liege Repository record

  16. Inhibition of biofilm growth on highly polycationic polyelectrolyte multilayers

    Park, Albert HMassachusetts Institute of Technology2008

    The epithelial cell adhesion molecule E-cadherin is often down regulated during carcinoma progression and metastatic spread of tumors. However, the precise mechanism and molecular basis of metastasis promotion by E-cadherin loss is not completely understood. To investigate its role in metastasis, I …

    mit Repository record

  17. Microfluidic Platforms for Investigating Cell Migration

    Silvestre, JonathanUniversity of Illinois at Urbana-Champaign2015

    … studies quantified the relative effects of E-cadherin expression and adhesive ligation on the migration velocities of mammary breast tumor cells. Micropatterned proteins were used to titrate the relative effects of E-cadherin and Fibronectin on the migration velocities of the metastatic …

    uiuc Repository record

  18. Examining the Role and Regulation of Cell-Cell Adhesion in Aggressive Prostate Cancer

    Barber, Alison G.2011

    … examine the efficacy of classical and desmosomal cadherins as prognostic biomarkers of aggressive prostate cancer. I began this study by characterizing the expression profile of desmosomal cadherins in normal human prostate and metastatic prostate cancer cell lines. This study revealed that DSG2, …

    columbia-diss Repository record

  19. Regulation of Homophilic and Heterophilic Adhesion Among Classical Cadherins

    Lee, Keng JinUniversity of Illinois at Urbana-Champaign2015

    Finally, fluorescence imaging assessed cadherin clustering and actin organization in E-cadherin expressing cells cultured on E-, N-, and C-cadherin ectodomains. As expected, the formation of filamentous actin correlated with the Rac activation amplitudes in E-cadherin expressing cells. The results …

    uiuc Repository record

  20. Contribution of specific amino acids to calcium-dependent dimerization of epithelial cadherin

    Howard, Xiaoyun Z.2020

    <p>Cadherins are calcium-dependent molecules that play essential roles in embryonic development, tissue morphogenesis, and cancer progression. Epithelial (E-) cadherin is present at adherens junctions, structures that are important for maintaining tissue integrity. At adherens junctions, cell–cell …

    mississippi Repository record

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