Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"E-box"”.
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Genome-Wide Analysis of Transcription Factors Ascl1 and Ptf1a in Development and Cancer
… is partly explained by their differences in E-box sequence preferences. Ptf1a and Ascl1 are co-expressed in a subset of cells in the dorsal neural tube, and comparative analysis of their binding sites show that they bind a common E-box. However, Ptf1a can also bind a distinct E-box, which is …
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Characterization of Neural Stem Cells Using the Nestin Enhancer
… enhancer located on nestin 2nd intron. Two E-boxes (CANNTG) in 637bp of the nestin 2nd intron (nestin enhancer) were thought to be strong candidates for bHLH factors during the early neurogenesis. ngn1 increased the second E-box mediated reporter gene activity. To evaluate the functional …
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Testes de ajustamento de modelos em processos com longa dependência
… baseados nas estatísticas propostas por Ljung e Box (1978), Monti (1994) e Pe˜na e Rodríguez (2002) nos processos ARFIMA(p; d; q). Consideramos o processo ARFIMA(p; d; q) nas situações adequadas para representar séries temporais com características de longa dependência. Para estimar o parâmetro …
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Neue Interaktionspartner der MAPKAP-Kinasen 3pK und MK2
… bHLH-Proteinen an sogenannte E-Box-DNA-Motive und ist so in die Regulation gewebespezifischer Genexpression und Zelldifferenzierung involviert. In dieser Arbeit konnten 3pK und MK2 als in vitro Kinasen des in Zellen phosphoryliert vorliegenden Transkriptionsfaktors identifiziert …
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RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1
… binding to a 21 base-pair site comprising an E-box (CANNTG) and a TC-box separated by one helical turn. P48 binds the E-box as a heterodimer with class A bHLH proteins, while the third member of the complex contacts the TC-box, but cannot stably bind without the P48 heterodimer. PTF1 activates …
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Part I characterization of MyoR in C2C12 mouse fibroblasts. Part II isolation and characterization of a novel class II bHLH transcription factor from the black widow spider, latrodectus hesperus
… differences in the DNAbinding complexes to an E-box site.</p> <p>Part II</p> <p>Members of the basic helix-loop-helix (bHLH) family are required for a number of different developmental pathways, including lymphopoiesis, myogenesis, neurogenesis and sex determination. Screening a eDNA library …
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Analysis of the role of extracellular signal regulated kinase (ERK5) in the differentiation of muscle cells
… the myosin light chain (MLC1A) gene, or an E-box containing promoter element, where myogenic basic-helix-loop-helix proteins such as MyoD or myogenin bind. Moreover, myogenic differentiation is completely blocked, when ERK5 expression is inhibited by antisense RNA. The effect can be detected …
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
… by the GSK-3 inhibitor BIO compound in both E-box (putative Snail binding site)-dependent and -independent manner. My results indicate that there are other Snail-independent transcriptional regulations involved in the regulation of RKIP expression.
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
… by the GSK-3 inhibitor BIO compound in both E-box (putative Snail binding site)-dependent and -independent manner. My results indicate that there are other Snail-independent transcriptional regulations involved in the regulation of RKIP expression.
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Characterization of ABF-1 in C. elegans and regulation of cellular growth and ID3 by human ABF-1
… with E2A gene products and binding E box binding sites. HeLa cells transfected with ceABF-1 reveal that it is capable of blocking E2A mediated gene transcription. In order to maintain full repression capabilities, two conserved amino acid residues within helix I ofthe HLH domain are …
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Structural studies on Ets1 and USF1 transcription factor complexes with DNA
… für den Transkriptionsfaktor USF1 (E-box) und für den Transkriptionsfaktor Ets1. Es gibt mehrere E-boxen auf HIV1 LTR, die USF1 an zwei Initiationselementen in der Nähe des Transkriptionstartelements auf HIV1 LTR binden kann (Du et. al., 1993). Es wurde vorgeschlagen, dass USF1 …
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Charakterisierung des 5-HT<sub>3B</sub>-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus
… NF-1 (Nuclear Factor-1). USF1 bindet an einer E-Box zwischen -183 bis -178 bp vor dem Startkodon. Eine Mutation der USF1-Bindungssequenz führte im -258 bp-Promotorfragment zu einer Abnahme der Aktivität um 55%. Die Überexpression von USF1 resultierte in einer signifikanten Zunahme der …
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Post-Transcriptional Regulation by microRNAS in Pregnancy and Parturition
… downregulated targets, zinc finger E-box binding homeobox proteins, ZEB1 and ZEB2, which act as transcriptional repressors. We also observed upregulation of the miR-200 family and downregulation of ZEB1 and ZEB2 in two different mouse models of preterm labor. We further demonstrated …
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Post-Translational Regulation of Zeb1 Contributes to Tgfβ-Mediated Emt
… of the transcription factor zinc finger E-box-binding homeobox 1 (Zeb1). Although Zeb1 has an established role in EMT the mechanism by which Zeb1 is regulated has not been fully elucidated. Here we demonstrate that Zeb1 undergoes post-translational modification and that this modification …
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Role of Sonic Hedgehog in Development of the Central Nervous System
… of the nestin gene through regulation of E-box on nestin 2nd intron 5’-region by Nmyc that is a target gene of Shh signaling. Shh also increased population and proliferation of neural stem cells in vitro or in vivo. In late stages, Shh induced specification of motor neurons as well as …
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Élucidation des déterminants structuraux impliqués dans la reconnaissance moléculaire entre MXD1 et MAX et la liaison à l'ADN
… l'influence de promoteurs contenant des sites E-Box, pendant que les complexes Mxd/Max permettent l'inhibition de la transcription à ces mêmes promoteurs. Cependant, l'activité oncogénique associée à la surexpression de c-Myc dans plusieurs cancers semble être assurée par l'inhibition de la …
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The role of circadian rhythms in reproduction: development and fertility in the bmal1 null mouse.
… the presence of circadian enhancer regions (E-box sequences) or RORA response elements (RRE) in their promoter regions. It was revealed that many of the genes investigated contained one or more circadian E-box and RRE sequence, providing a mechanism for the disruption of circadian gene …
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The Role of Mga in the Survival of Pluripotent Cells During Peri-implantation Development
… transcription factor Mga contains both a T-box binding domain and a basic helix-loop-helix zipper (bHLHZip) domain. Loss of Mga leads to embryonic lethality by E5.5. In vitro blastocyst culture and embryonic stem (ES) cell culture identify a lack of pluripotent inner cell mass (ICM) derived …
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Essays on data transformation and regression analysis
… que indexam as transformações de Manly e Box-Cox, usadas para transformar a variável resposta do modelo de regressão linear, e também testes de hipóteses. A tese é composta por quatro capítulos. No Capítulo 2, desenvolvemos dois testes escore para a transformação de Box-Cox e dois testes …
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Aspectos epidemiológicos e de resistência à Ralstonia solanacearum na cultura da batata no Rio Grande do Sul
… A análise dos resultados da PCR-ERIC e BOX de 13 estirpes da biovar 1 e 72 da biovar 2 demonstrou baixa variabilidade genética. Através de RAPD foi possível associar local de origem do isolado com perfil eletroforético. Em outro experimento avaliou-se o comportamento de 14 cultivares e …
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