Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 161 for “"E-Cadherin"”.
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E-cadherin mechanotransduction beyond cell-cell junctions
Cadherins and integrin receptors form crucial extracellular adhesive connections with, respectively, adjacent cells and the extracellular matrix, and transduce mechanical signals across cell membranes. The role of adhesive complexes in diseases, cardiomyopathies, atherosclerosis, cancer, stem cell …
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Expression of E-cadherin and HGF in Hypopharyngeal Cancer
… cancer which has relatively poor prognosis. E-cadherin is a large family of Calcium dependent intercelluar Adhesion Molecule(CAM) whose functions are essential for the induction and maintenance of intercellular cohesion and hepatocyte growth factor(HGF), a potent stimulator of hepatocyte …
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Mechanism of E-cadherin dimerization at the plasma membrane
Embargo set by: Seth Robbins for item 118623 Lift date: 2023-09-17T04:04:53Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system
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Molekulare Alteration im E-Cadherin-Gen bei malignen Melanomen und kolorektalen Karzinomen
E-cadherin belongs to the cadherins,which constitute a large family of calcium-dependent cell adhesion molecules. Cell-to-cell adhesion plays a critical role in the development and maintaince of complex differentiated epithelial tissues and structures in multicellular organisms. Interference with …
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INVESTIGATING ALTERNATIVE SPLICING REPROGRAMMING REGULATED BY THE E-CADHERIN/B-CATENIN AXIS
… behind this dysregulation, pinpointing E-cadherin and β-catenin as central players in myosin VI AS regulation. β-catenin's nuclear translocation induces myosin VIshort expression, while its depletion rescues myosin VIlong. Furthermore, we uncovered β-catenin's broader involvement in AS …
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Aufklärung der Funktion von E-Cadherin in der Pluripotenz und Reprogrammierung somatischer Zellen
… Besonders die Expression des zur Familie der Cadherine gehörenden Moleküls E-Cadherin ist entscheidend für die Bildung der kompakten Morula, ein frühes Stadium der Embryonalentwicklung, aus der sich die Blastozyste bildet. Die Blastozyste enthält die innere Zellmasse (ICM), eine Ansammlung …
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Epidermal growth factor receptor is an essential component in E-cadherin force-transduction complexes
… on the structural functional analysis of E-cadherin and EGFR interaction and their role in mediating E-cadherin mechanotransduction. E-cadherin serves as molecular Velcro in epithelial cells to maintain epithelial homeostasis. Despite passively bearing mechanical stress at cell-cell …
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Role of e-cadherin in tumor metastasis and discovery of compounds targeting metastasis cancer cells
The epithelial cell adhesion molecule E-cadherin is often downregulated during carcinoma progression and metastatic spread of tumors. However, the precise mechanism and molecular basis of metastasis promotion by E-cadherin loss is not completely understood. To investigate its role in metastasis, I …
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Die Expression von E-Cadherin in der Embryonalentwicklung der Maus : Analyse von cis-aktiven regulatorischen Elementen
Korrekte Regulation der Transkription des E-Cadheringens zur Etablierung von homophiler Zell-Adhäsion ist notwendig für einwandfreie frühe Embryonalentwicklung und Organogenese. Trotz der Bedeutung von E-Cadherin bei der Embryogenese, im intakten Organismus, sowie der veränderten Expression bei der …
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Μελέτη της E-cadherin σε δείγματα καρκίνου μαστού και του σύστοιχου λεμφαδένα: ο ρόλος στη μετάσταση
… ρύθμιση της μετάστασης είναι η έκφραση της E-cadherin. Αν και έχει περιγραφεί ως βασικό μόριο επιθηλιακών διακυτταρικών συνδέσεων, με τη μείωση της έκφρασής της να επιτρέπει στα καρκινικά κύτταρα να διαφεύγουν και να μεταναστεύουν, εντούτοις η παρουσία της είναι απαραίτητη για τη διατήρηση των …
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Role of shNDPK and E-Cadherin in Growth and Metastasis of an Inflammatory Breast Cancer Model (MARY-X)
… by inducing endothelial cell proliferation. E-Cadherin, an adherence protein, is overexpressed in MARY-X spheroids and is responsible for the densely aggregated configuration and the stem cell-like nature of the in vivo emboli and the in vitro spheroids. We will also investigate specific …
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Systemic Leptin Modulates the Expression of E-cadherin, β-catenin in the Ovary of Dietary-Induced Obese Infertile Rats
… is poorly understood. Recent evidence indicates Ecadherin/ β-catenin complex, which is a structural constituent of adherens junction, is expressed in the rat ovary during folliculogenesis. We hypothesized that systemic leptin modulates the expression of E-cadherin and β-catenin in dietary-induced …
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Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape
… factors. Amongst the genetic factors, the E-cadherin (CDH1) gene is said to play a major role in the development of gastric cancer. Both germline and somatic mutations have been identified in the CDH1 gene. The germline mutations span the entire exon of this gene and are seen in approximately …
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The regulation of LIV-1 mRNA in MDA-MB-231 human breast cancer cells and its association with E-cadherin (CDH1)
… the expression of the cell adhesion protein, E-cadherin (CDH1), thought to play a role in metastasis. In the present study, we investigated the regulation of LIV-1 and its relationship to CDH1 in MDA-MB-231 ER<sup>-</sup> breast cancer cells. Cells were treated with insulin and EGF for 24 hours …
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A morphologic and immunohistochemical analysis of gastric adenocarcinoma with regard to the presence of E-cadherin and localisation of β-catenin staining
Includes abstract. Includes bibliographical references.
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Inhibition of biofilm growth on highly polycationic polyelectrolyte multilayers
The epithelial cell adhesion molecule E-cadherin is often down regulated during carcinoma progression and metastatic spread of tumors. However, the precise mechanism and molecular basis of metastasis promotion by E-cadherin loss is not completely understood. To investigate its role in metastasis, I …
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Microfluidic Platforms for Investigating Cell Migration
… studies quantified the relative effects of E-cadherin expression and adhesive ligation on the migration velocities of mammary breast tumor cells. Micropatterned proteins were used to titrate the relative effects of E-cadherin and Fibronectin on the migration velocities of the metastatic …
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Examining the Role and Regulation of Cell-Cell Adhesion in Aggressive Prostate Cancer
… examine the efficacy of classical and desmosomal cadherins as prognostic biomarkers of aggressive prostate cancer. I began this study by characterizing the expression profile of desmosomal cadherins in normal human prostate and metastatic prostate cancer cell lines. This study revealed that DSG2, …
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