Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"E₂(PGE₂)"”.
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A Possible Role For Prostaglandin E-B2-S as a Suppressor of Macrophage Phagocytosis
… macrophages were treated with prostaglandin E₂ (PGE₂) they phagocytized L. monocytogenes at a rate comparable to that phagocytized when treated with a low molecular weight fraction of Concanavalin A generated spleen cell culture supernatant. Suppressive activity of spleen cell culture …
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Regulation of macrophage activities by tumor growth: mechanisms of immunosuppression
… of the suppressor molecules prostaglandin E₂ (PGE₂), nitric oxide (NO), and tumor necrosis factor-α (TNF-α). A major finding was that TNF-α's normal up-regulatory action on T-cell proliferation switched to a suppressor action when Mφ were present. The autocrine action of increased TNF-α …
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Progesterone control of human endometrial cells
… kinase A/cAMP pathway, such as Prostaglandin E₂ (PGE₂) and relaxin, are potent inducers of decidualisation when administered alongside progesterone in endometrial stromal cells (ESCs) in vitro. Uterine Natural Killer (uNK) cells increase in number in secretory phase endometrial stroma, …
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Arachidonic acid metabolism by early ovine embryos and the role of prostaglandins in one aspect of embryonic development
… prostaglandin F₂⍺ (PGF₂⍺), prostaglandin E₂ (PGE₂), 13,14-dihydro-15-keto prostaglandin F₂⍺ (PGFM), prostaglandin B₂ (PGB₂) and 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT). Experiment 2 was to determine whether prostaglandins have a role in embryo hatching from the zona pellucida. Ewes …
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The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
Prostaglandin E₂ (PGE₂), the most abundant prostaglandin (PG) in our body, has multiple biological functions related to physiological activities and the development of diseases. Emerging evidence has shown that PGE2 plays an important role in regulating the survival and proliferation of …
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Tumor-induced macrophage and T cell dysfunction
… (IFN-y), interleukin-4 (IL-4), and prostaglandin E₂ (PGE₂) production. TBH MΦ had aberrant regulation of granulocyte-macrophage colony-stimulating factor (GM-CSF). TBH MΦ produced less GM-CSF than normal host (NH) MΦ. GM-CSF failed to increase class II molecule expression on TBH MΦ, and TBH class …
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Tumor-induced immunosuppression: Contribution of a high molecular weight inhibitor and Prostaglandin E2
… Concentrated supernatants were prostaglandin E₂ (PGE₂)-free and yet inhibited proliferation in the mixed lymphocyte reaction (MLR) and mitogen assays. The high mw inhibitory factor was apparently >67 kd, as shown by S-200 Sephacryl chromatography and gel electrophoresis. DEAE-Cellulose …
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ROLE OF OXYTOCIN AND OXYTOCINASE IN THE MATERNAL RECOGNITION OF PREGNANCY
This thesis involved the investigation of luteal, endometrial and embryonic putative gene regulators in the maternal recognition of pregnancy in the horse, with an emphasis on understanding the role of oxytocin and oxytocinase in early pregnancy. The first objective was to validate the safety and …
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Systems Biology Approach to Identifying Host Interactive Pathways Modulating the Severity of Streptococcal Sepsis
<p>Clinical outcomes of infectious diseases are controlled by complex interactions between the host and the pathogen. Epidemiological, genetic and molecular studies in my mentor’s laboratory provided evidence that in invasive Group A streptococcal (GAS) infections, genetic variations in both …
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Die Wirkung mehrfach ungesättigter Fettsäuren auf Schlüsselproteine der Knorpeldegeneration in einem Modellsystem für die canine Osteoarthrose
Einleitung: Osteoarthrose (OA) ist eine der häufigsten muskuloskelettalen Erkrankungen beim Hund und wird definiert durch einen fortschreitenden Verlust der Knorpelschicht auf den Gelenksflächen. Therapeutika erster Wahl, wie nichtsteroidale Antiphlogistika, wirken rein palliativ und haben …
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Cyclooxygenase-2 is Associated with Cadmium-induced ICAM-1 Expression in Brain Endothelial Cell
… expression, and thereby prostaglandin E2 (PGE₂) production in bEnd.3. Based on the previous report that PGE₂ is one of the key regulators in the expression of cell adhesion molecule, in this study, we explored the possible role of COX-2 in Cd-induced ICAM-1 expression in bEnd.3. Cd …