Global ETD Search
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Showing 1 to 10 of 10 for “"Dystroglycan"”.
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An investigation into dystroglycan deficiency in fibroblasts and a role for dystroglycan in cytokinesis
Dystroglycan is a heterodimeric cell adhesion molecule consisting of alpha and beta subunits, which links the actin cytoskeleton to the extracellular matrix. Dystroglycan has an important structural role and is integral for maintaining tissue integrity, but new avenues have research have implicated …
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Pathobiology of glomerular alpha-dystroglycan
Contains fulltext : 89847.pdf (Publisher’s version ) (Open Access)
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Structural and Functional Aspects of Dystroglycan During Agrin -Mediated Acetylcholine Receptor Clustering at the Mammalian Neuromuscular Junction
Prior studies on dystroglycan support dystroglycan as an agrin-binding protein. More specifically, data suggests that the carbohydrate residues on dystroglycan may be involved in binding to agrin. However, genetic and functional studies on dystroglycan's role in agrin-mediated acetylcholine …
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Determination of Genetic Interactions Required for Dystrophin-Dystroglycan Function and Regulation in a Drosophila Model of Muscular Dystrophy
Im Menschen hängen genetisch diverse Formen von Muskeldystrophie (MD) mit einer Schädigung des Dystrophin-Glykoprotein Komplexes (DGC) zusammen. Der DGC besteht aus Dystrophin, Dystroglykanen, Sarkoglykanen, Sarkospan, Syntrophinen und Dystrobrevin. Die Charakterisierung des Drosophila melanogaster …
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Elektrophysiologische Untersuchung der synaptischen Übertragung und Kurzzeitplastizität an der neuromuskulären Synapse von Drosophila melanogaster
… des Dystrophin- Assoziierten Glykoproteins Dystroglycan (DG) sowie der Cyclin-abhängigen Kinase 5 (CDK5) untersucht. Für Larven, die GluRIIB exprimieren, jedoch nicht GluRIIA, konnte ein im Vergleich zu Wildtyp-Larven schnellerer Abfall (verminderter decay-τ) und verminderte Amplitude …
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Protein-Protein Interactions and Muscle cell Signaling Via Syntrophin
… constituents are dystrophin, a-dys troglycan, b-dystroglycan, syntrophin, a-sarcoglycan, b-sarcoglycan, g-sarcoglycan, d-sarcoglycan, and sarcospan. Not al l of these are single protein species. The syntrophins consists of a group of three homologous proteins composed of acidic (a) and basic (b) …
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Die Wirkung von Agrin auf die Genexpression isolierter Maus-Podozyten in Langzeitkultur
… Strukturprotein hilft es, die Podozyten über a-Dystroglycan in der glomerulären Basalmembran zu verankern und trägt durch seine negativ geladenen Heparansulfat-Seitenketten entscheidend zum Ladungsfilter der glomerulären Basalmembran bei. <br>Seine Rolle als Signalprotein am Glomerulus ist …
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Identification and characterisation of novel marker proteins involved in X-linked muscular dystrophy
… with its homologue utrophin, restoration of β-dystroglycan was observed along with an increased concentration in heat shock proteins. While the severely affected cardiac muscle exhibited drastic decreases in the expression levels of many proteins involved in energy metabolism including …
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Investigation of the use of extracellular vesicles for the treatment of congenital muscular dystrophy
Aberrant glycosylation of alpha-dystroglycan (α-DG) leads to a group of pathologies known as dystroglycanopathies. Mutations in the gene encoding fukutin-related protein (fkrp) are one of the most common causes of secondary dystroglycanopathy in the UK. Mutations in fkrp prevent complete …
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Gene expression studies of pregastrulation development: the basement membrane is essential for cell differentiation
… and consequently binding to the receptor dystroglycan are not crucial in diaphragm and heart, but essential in the peripheral nervous system.