Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Dyskinesia"”.
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Primary ciliary dyskinesia: a biopsychosocial approach
Background: Primary ciliary dyskinesia (PCD) is a rare heterogeneous genetic disorder associated with abnormal ciliary structure and function and characterised by progressive sinopulmonary disease. There is no ‘gold standard’ for diagnosing PCD. This thesis aimed: to provide an overview of the PCD …
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Building capacity for diagnosis of Primary Ciliary Dyskinesia in South Africa: a descriptive study
Background: Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by abnormal cilia motility. Diagnostic capacity for PCD in sub-Saharan Africa (sSA) is limited; and incidence of PCD and genotype in sSA is unknown. Objectives: To determine the prevalence of PCD in children and …
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Primary Ciliary Dyskinesia: An Epidemiological Exploration. Furthering our understanding of the burden of disease in PCD
Primary ciliary dyskinesia (PCD) is an underrecognized multisystem genetic disorder that is characterized by dysfunctional motile cilia and abnormal mucociliary clearance. In recent years, there have been significant advancements in the understanding of PCD including, but are not limited to, …
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A behavioural evaluation of the potential of nNOS inhibitors to control dyskinesia in animal models of Parkinson’s disease
… (PD) can lead to motor complications including dyskinesia which can be treated with amantadine, an N-methyl-D-aspartate (NMDA) receptor antagonist. NMDA receptor activation is linked with nitric oxide (NO) production and changes in synaptic plasticity, suggesting a role in dyskinesia. This led …
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Use of wearable ambulatory monitor in the classification of movement states in Parkinson's disease
… how the patient's bradykinesia/hypokinesia and dyskinesia fluctuate throughout the normal daily activities. This thesis proposes the use of wearable accelerometers coupled with machine learning and statistical techniques in order to classify the movement states of Parkinson's patients and to …
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Investigating the role of neuroinflammation in a mouse model of L-Dopa induced dyskinesia and exploring the anti-dyskinetic potential of a cannabinoid receptor agonist
… implicated in the development of L-Dopa induced dyskinesia (LID), a PD side effect that arises with chronic L-Dopa treatment. This thesis had two major aims; First, we aimed to characterize the neuroinflammatory phenotype present in a mouse model of PD and LID. Second, we aimed to determine …
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The effect of tranquilizing agents on diadochokinetic movement in a senile psychotic population
… effects of long term phenothiazine therapy (dyskinesia ) would show a reduced rate of diadochokinetic movement when compared with an age-matched group exhibiting no such symptoms and with no history of having taken tranquilizers . Furthermore, if this diadochokinetic movement were reduced, …
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Therapeutic strategies of Parkinson's disease: Alternative dopamine replacement and potential drug targets
… side effects, including L-DOPA-induced dyskinesia (LID), among other motor complications, in most patients. Thus, emerged the urgent need to overcome L-DOPA's toxic side effects and increase its efficacy to improve quality of life. Moreover, the need for identifying a new therapeutic …
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Genetic Approach to Discover ARMC4 as a Novel NF-κB Negative Regulator and Tumor Suppressor in Colorectal Cancer
… known to date for its role in primary ciliary dyskinesia (PCD) and mouse spermatogenesis. Thus, my work reveals a completely new facet of ARMC4 function that has never been reported before. We showed that ARMC4 overexpression downregulated the expression of NF-κB-dependent genes, many of which …
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Wireless Sub-Cellular Sized Stimulators for Minimally Invasive Deep Brain Stimulation with High Spatiotemporal Resolution
… as tremor) or are caused by it (levodopa-induced dyskinesia). However, current DBS technology comes with inherent limitations and problems, including: 1) the need of a large invasive foreign body (the electrode) which can cause lead infections, 2) low coverage of entire movement-related territory …
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Novel endoscopes for microscopic assessment of airway clearance using micro-optical coherence tomography
… patients with cystic fibrosis, primary ciliary dyskinesia and chronic obstructive lung disease. However, no tool for microscopic in-vivo visualization of ciliary function is currently available, limiting studies of disease pathogenesis, refined diagnosis and phenotyping, and the development of …
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Temporomandibular Disorder Related Characteristics and Treatment Outcomes in Oromandibular Dystonia Patients in Two Different Clinical Settings: A Cross-Sectional Study
… secondary to Parkinson’s disease and Tardive dyskinesia patients. The survey questionnaire was designed to collect information on demographic characteristics, clinical presentation particularly related to TMD, quality of life and treatment outcomes. Validated questionnaires were used when …
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Putative changes in dopaminergic neurotransmission following nicotine induced behavioural sensitisation
… schizophrenia, addiction, depressive disorders, dyskinesia, and psychosis) although its own mechanism remains contentious. In this thesis a multidisciplinary approach was used to investigate the role of dopamine in behavioural sensitisation. Different in vivo and ex vivo techniques were used to …
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Characteristics That Discriminate Between Successful and Unsuccessful Drug Withdrawal Candidates Among Mentally Retarded Persons (Neuroleptic, Psychotropic, Major Tranquilizers)
… number of months on drug, presence of tardive dyskinesia, or more importantly, the behavioral reasons for initial prescription of drugs were found to be reliable predictors of remaining on neuroleptic medication. The implications of this investigation for clinical-drug monitoring systems are …
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The Role of the Cortico-Basal Ganglia-System in Voluntary Movements
… is impaired. Here we found that levodopa induced-dyskinesia was tightly associated with a strong oscillatory phenomenon in the motor cortex, and that stopping the oscillation locally was sufficient for alleviation of motor symptoms. By expanding the neuronal recordings using the developed …
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Understanding the Collective Dynamics of Motile Cilia in Human Airways
… or patients affected by Primary Ciliary Dyskinesia. Our description of the beating pattern, and the selection of a few meaningful, summary parameters, are then shown to be accurate enough to discriminate between different mutations within Primary Ciliary Dyskinesia. In Chapter 6 instead I …
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Surgical ventricular reconstruction for ischemic or idiopathic dilated cardiomyopathy
… for either left ventricular akinesia or dyskinesia results in better clinical outcome than classic aneurysmectomy or conservative medical therapy. The reason is the focus of this procedure on restoring the physiological dimensions of the remodeled ventricle by excluding noncontracting …
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Development and application of a high throughput cell based assay to identify novel modulators of ERK1/2 activation and,Functional characterisation of the candidate Radial spokehead like (Rshl1)
… on chromosome 19q13.3 at the primary ciliary dyskinesia locus, and the encoded protein contains a radial spoke domain. However, the biological role of this protein was not described. I found that Rshl1 indeed localizes to primary cilia but also to the cytoplasm and nucleus of human kidney …
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Mutational Analysis to Define the Functional Role of the Third Intracellular Loop of D1-Class Dopaminergic Receptors
… disorders such as in the case of L-DOPA induced dyskinesia (LID) seen in individuals suffering from Parkinson’s disease.
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