Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 111 for “"Dysbiosis"”.
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Targeting Airway Microbiome Dysbiosis for Preventing Pediatric Subglottic Stenosis
Subglottic stenosis (SGS) is a significant health care complication following intubation in pediatric intensive care units. In the United States, SGS impacts nearly 8% of over 20,000 early-term patients annually, leading to comorbidities such as congenital heart disease and central nervous system …
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Gut Microbiome Dysbiosis Exacerbates Malaria Severity in Ugandan Children
… revealed that children with SM have gut bacteria dysbiosis, defined by an increased relative abundance of potentially pathogenic Enterobacteriaceae. Enterobacteriaceae thrive in the presence of inflammation and use diverse nutrients to support growth, and several features of SM associated with gut …
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Investigating dysbiosis as a cause and predictor of intestinal pathology
Intestinal dysbiosis involves a shift in microbial composition and abundance within the gut and compelling evidence has highlighted the pivotal role dysbiosis plays in the onset and pathogenesis of numerous diseases, including inflammatory bowel disease (IBD), allergies and even mental health …
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Characterising dysbiosis in Alzheimer’s disease utilising the APP/PS1 mouse model
… to WT littermates. By fifteen-months the dysbiosis had recovered, however there was a decrease in goblet cells in the villi and crypts of the ileum. A three-month age group was introduced which was found to have a significant difference in the mucosal- associated microbiota in the caecum …
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Unraveling the Microbiome Connection: Exploring the Nexus of Endometriosis, Anxiety, and Dysbiosis
Endometriosis is a complex gynecological disease affecting approximately 10-15% of individuals assigned female at birth, and often presents with co-occurring symptoms of anxiety. Available evidence from preclinical and clinical research suggests that alterations of the microbiome may play a key …
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Changes in the Gut Metabolic Landscape Drive Inflammation-Associated Dysbiosis and Host Responses
The file named "HUGHES-PRIMARY-2022-1.pdf" is the primary dissertation file. Three (3) supplemental files are also available and are referenced in the dissertation file as appendices; the files are Microsoft Excel documents and may be viewed individually.
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Modulation of Neurodevelopmental Outcomes using Lactobacillus in a Model of Maternal Microbiome Dysbiosis
… brain axis. Importantly, antibiotics cause dysbiosis of the gut microbiome and disrupt the delicate composition of the microbial inoculum transferred from mother to child, which is critical for development of the immune system and holds implications for long-term health outcomes. The …
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Dysbiosis-Associated Changes in Host Metabolism Produce Lactate to Support Enterobacterial Expansion During Inflammation
The lumen of the gastrointestinal tract is heavily colonized by microbes, termed the gut microbiota. Under normal conditions, fermentative anaerobes constitute the majority of the gut microbiota. However, during inflammation there is a change in the nutritional environment of the gut that enables …
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The Role of Dysfunctional Na+/H+ Exchange in the Development of Dysbiosis and Subsequent Colitis
The last half-century has seen a dramatic and alarming rise in the incidence of autoimmune disease in industrialized nations too rapid to be accounted for by genetics alone. Among those, Inflammatory Bowel Disease (IBD) has risen from a western disease affecting industrialized populations to an …
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AGE-RELATED GUT DYSBIOSIS ACCELERATES THYMIC INVOLUTION AND ALTERS PERIPHERAL T CELL REPERTOIRE IN DUCHENNE MUSCULAR DYSTROPHY
Emerging researches highlight a significant interplay between the immune system and skeletal muscle, particularly in the context of inflammatory muscle disorders and dystrophic conditions like Duchenne Muscular Dystrophy (DMD), as well as during the natural process of muscle regeneration. …
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Data Management tools For Metagenomic Datasets, A Case Study: Characterization and Dysbiosis of Gut Microbiota In Apcmin/+ Mice With and Without Colon Tumors
<p> Microorganism's makeup half of earth's biomass and are known to be the largest reservoir of biodiversity and genetic potential. They play an important role in maintaining equilibrium in the environment by taking part in several biogeochemical cycles. Microbes are found in every habitat, …
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Colonocyte-Derived Lactate Promotes Enterobacteriaceae Fitness During Non-Infectious Colitis
… and antibiotic-associated gut microbiota dysbiosis and worsened disease severity of chemically-induced murine colitis. Though we did not identify the molecular mechanisms underlying the helminth-associated exacerbation, we further explored how Enterobacteriaceae metabolism contributes …
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Microbiota-host interactions and infection dynamics in critical illness.
… defense. We recently reported that intestinal dysbiosis in critically ill patients is associated with expansion of hypofunctional immature neutrophils, resulting in a significant reduction in infection-free survival. To further establish the causal impact of Enterobacteriaceae enrichment on …
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Diet- and Probiotic-mediated Modulation of the Maternal Gut Microbiome Impacts Early-life Programming of Neurodevelopment and Behavioral Outcomes in Offspring
… in offspring. Specifically, disruption, or ‘dysbiosis,’ of the maternal gut microbiome during pregnancy is associated with adverse neurodevelopmental outcomes. Previously, we showed that maternal high-fat diet (MHFD) in mice induces gut dysbiosis, social dysfunction, and underlying synaptic …
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Exploring the gut microbiome: metaproteome analysis of HIV-exposed uninfected infants
… and balance for optimal host health. Gut dysbiosis is linked to diseased states, with gut dysbiosis being well documented amongst HIV infected individuals. HEU infants' altered immunity and health could be linked to gut dysbiosis. Looking into the metaproteome of the infant gut to find any …
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Epigenetic Changes in the Innate Response of Gingival Epithelium
… with P. gingivalis that may instigate epithelial dysbiosis that may create a unique pathogen niche in the gingival crevice and susceptibility to periodontitis.
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Characterization of putative sialidase genes in Gardnerella vaginalis
… vaginalis is a hallmark organism in the dysbiosis bacterial vaginosis (BV) in reproductive age women although its role in this condition is not currently understood. Diversity within G. vaginalis in terms of virulence factors such as sialidase activity, may explain why it is also observed …
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Probiotic Use in Trauma Patients: A Pathway to Determining the Standard of Care to Improve Outcomes
… associated with microbial imbalance, or dysbiosis. In addition to the mechanisms of traumatic injury that can impair one’s immune function, these patients are subjected to a variety of treatments and therapies that account for a tendency toward dysbiosis which can lead to …
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Examining the gut microbiota in aging
… tonic appetite signals (leptin, insulin). Gut dysbiosis, or an imbalance in the gut microbiome, leads to altered metabolic processes, increased epithelial permeability, and systemic inflammation that contribute to health issues like metabolic dysfunction (type 2 diabetes [T2D]), cardiovascular …
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Computational prediction of health status from the human gut microbiome and metabolome
… human well-being. Gut microbiome dysfunction, or dysbiosis, has been implicated in a broad range of diseases including inflammatory bowel diseases (IBDs), cardiovascular diseases, kidney diseases, metabolic diseases, and gastrointestinal infections like Clostridioides difficile infection (CDI). …
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