Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Dyrk"”.
-
Mechanisms Regulating The P120-Catenin/Kaiso Pathway
… <p>In my second project, I found that the Dyrk1A kinase exhibits a <em>positive</em> effect upon p120-catenin levels. That is, unlike the negative regulator GSK3b kinase, a candidate screen revealed that Dyrk1A kinase enhances p120-catenin protein levels via increased half-life. Dyrk1A is …
-
Characterising FAM117 proteins as novel targets of DYRK1B
… tyrosine phosphorylation-regulated kinases (DYRKs) represent an understudied family of protein kinases. Whilst DYRK1A has garnered more attention due to its links to Downs’ Syndrome and Alzheimer’s Disease, the other class I DYRK, DYRK1B, remains comparatively unexplored. Prior work in our …
-
Defining novel targets and functions of the protein kinase DYRK2
… tyrosine-phosphorylation regulated kinases (DYRKs) are a family of protein kinases that are distantly related to the mitogen-activated protein kinases (MAPKs) and cyclin-dependent protein kinases (CDKs). Hundreds of substrates and interacting partner proteins have been identified for MAPKs …
-
The Discovery and Synthesis of Novel DYRK1A Inhibitors for Various Oncologic Targets
… tyrosine phosphorylation regulated kinase-1A (DYRK1A) as a potential treatment approach for certain DYRK associated pathologies. A series of Groebke–Blackburn–Bienaymé (GBB) based analogs were synthesized and assessed, showing somewhat promising activity. Further profiling of this series has …
-
Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression
… of this thesis it was demonstrated using the DYRK family of isoenzymes that the presence of a priming kinase enhances GSK-3 phosphorylation and stimulates NRF2 degradation. Also, it has been shown that DYRK family members carry out priming of NRF2 through phosphorylating Ser-347, which …
-
Roles of the TORC1 Signaling in Stress Response and Chronological Lifespan Extension in Yeast
… of TORC1, the Greatwall kinase Rim15p and the DYRK kinase Yak1p, both of which are activated in TORC1-inhibited cells. Hyper-accumulation of storage carbohydrate and elevated H₂O₂-scavenging activity in the gtr2Δ and pib2Δ cells were dependent on RIM15 and YAK1. Furthermore, chronologically …
-
Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
… kinases, including the PAS kinase Rim15, the DYRK kinase Yak1, the GSK-3 homologue Mck1 and the energy-sensing SNF1 complex, were converged to regulate starvation-induced expression of molecular chaperones, metabolic reprogramming to accumulate storage carbohydrates, activation of antioxidant …
-
Zur Funktion der Kinase Dyrk1A im Gehirn der adulten Maus
… brain size and learning and memory deficits. Dyrk1A is the mammalian homologue of minibrain; the encoded protein is the founding member of the family of Dyrk protein kinases. The human DYRK1A gene is implicated in the emergence of the cognitive deficits in Down syndrome, due to its location on …