Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Dynein/dynactin"”.
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Investigating the cytoskeleton and microtubule-based transport with in situ cryo-electron tomography
… that drive intracellular transport. Cytoplasmic dynein, in combination with dynactin and activating adaptors, is a microtubule-based motor that drives long-range transport of many cargo types towards microtubule minus ends. Structural and cellular work to date has revealed how dynein-dynactin …
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Unraveling the multifunctionality of human Spindly
… was shown to be required for recruitment of the dynein/dynactin motor complex to kinetochores thus to promote chromosome alignment and mitotic progression. Kinetochore recruitment of the dynein/dynactin motor complex is crucial for maturation of kinetochore-microtubule attachments and for …
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Visualisation of dynein complexes in vitro and inside cells
… cargo over long distances. In axons, cytoplasmic dynein-1 (dynein) is the microtubule motor which carries cargo back towards the cell body. Dynein cargo include endolysosomal vesicles, autophagosomes and mitochondria. Dynein is activated by binding to a co-factor called dynactin. How dynactin …
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The role of ZW10 and its binding partners in chromosome segregation
… I discovered a non-redundant role for CLIP- 170, dynein/dynactin, LIS 1 and TOG I in chromosome congression to the metaphase plate. Selective depletion of dynein/dynactin and CLIP- 170 from mitotic kinetochores by RNAi of ZW 10, uncovered a novel role for these proteins in the initial …
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Functional characterization of the novel centrosomal protein Nlp (ninein-like protein)
… their capacity to associate with the cytoplasmic dynein-dynactin complex, a molecular motor complex primarly involved in the maintainance of Golgi architecture. We propose that the excess of Nlp and ninein could induce the disruption of the Golgi apparatus by sequestering the dynein-dynactin …
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The Role of Spindle Orientation in Epidermal Development and Homeostasis
… LGN, Nuclear mitotic apparatus (NuMA) and dynein/dynactin, plays a key role in establishing proper spindle orientation during ACDs. Two of these proteins, NuMA and dynein, interact directly with astral microtubules (MTs) that emanate from the mitotic spindle. While the contribution of these …
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A Genome-Wide Screen on Modifiers of Tau-Induced Neurodegeneration Using RNAi-Mediated Gene Silencing in Drosophila
… beteiligt sind, darunter Bestandteile des Dynein/Dynactin-Komplexes, der für den retrograden Mikrotubuli-basierten Transport verantwortlich ist. Experimente zur Aufklärung der funktionalen Zusammenhänge zwischen retrogradem Transport und Tau-vermittelter Toxizität weisen darauf hin, dass in …
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Investigating dynein-based transport of intracellular pathogens
Cytoplasmic dynein is a major microtubule-based motor which powers the long-distance transport of organelles, vesicles and other cytoplasmic contents from the cell periphery towards the centre. While dynein typically moves cellular cargoes, it can also be hijacked by pathogens that rely on …
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The structure of the cytoplasmic dynein tail
Cytoplasmic dynein is a molecular motor that moves cargos along microtubules. Dynein, together with its large co-factor dynactin, is responsible for the vast majority of traffic towards the centre of the cell. The largest subunit of the dynein complex is called the dynein heavy chain (DHC). The DHC …