Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Dynamins"”.
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Dynamins and myosin-II regulate the distinct modes of synaptic vesicle exocytosis in mature cerebrocortical nerve terminals and this involves calcium dependent phosphorylations.
… The results show that the inhibition of dynamins can increase the FM2-10 dye release during certain stimulation conditions (4AP5C and ION5C; where 5C represents 5 mM [Ca2+]e) without changing the Glu released indicating that dynamin(s) are required for the closure of the fusion pore (and …
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Phosphorylation sites on specific neuronal proteins can control the mode of synaptic vesicle exocytosis and thereby regulate synaptic transmission
… 5 mM Ca2+. In this model employed, myosin-II and dynamins can regulate the closure of the fusion pore of the readily releasable pool (RRP) of SVs during KR but are independent of each other’s actions. In biochemical assays, synaptosomes were maximally labelled with FM2-10 dye such that both the …
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Röntgenstrukturanalyse der GTPase-Domäne von Dynamin 1 und der Motordomäne von Myosin II
… Beschreibung der Nukleotidbindungsregion eines Dynamins. Im Gegensatz zu anderen GTPasen ist das switch I-Threonin, das für die GTP-Koordination wichtig ist, in Dynamin 1 in seiner katalytisch aktiven Konformation gehalten. Desweiteren konnte anhand des Strukturmodells für Arg59 eine Funktion …
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Genetic Dissection of Synaptic Vesicle Endocytosis
… compensatory mechanisms to deal with the loss of dynamins 1,2 and 3. Overall, my data demonstrate that dynamin is crucial but not essential for synaptic vesicle endocytosis. Dynamin is an activity dependent GTPase that is required for synaptic vesicle recycling after exocytosis of multiple …
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The role of protein phosphorylation in the switching between modes of synaptic vesicle release
… Investigations were carried out to see if dynamins or myosin 2 could regulate the fusion pores of synaptic vesicles since these proteins have been hypothesised to play such a role in non-neuronal exocytosis. Inhibition of dynamin 1 and 2 by dynasore revealed that for some stimuli, such …
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Biochemical differences in the modes of synaptic vesicle release between control and streptozotocin-induced diabetic rats and possible relationship to changes in behaviour
… works on RP of vesicles. The inhibition of dynamins switched the mode of exocytosis of the RP of SVs from K&R to FF in diabetic terminals, whilst failing to regulate the mode of exocytosis of the RRP for both control and diabetic terminals when a strong stimulus was applied. It has been …