Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Dynamin-Related Protein 1"”.
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Drp1 inhibition is protective against mitochondrial and autophagic impairment induced by alpha-synuclein
… (α-syn) pathology is one of the key proteins involved in PD pathology, it has been found to induce mitochondrial dysfunction, yet the mechanism is not entirely understood. This thesis project tests the hypothesis that α-syn induces mitochondrial dysfunction through disruption of …
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Mitochondrial Fission After Traumatic Brain Injury
… Specifically, dysregulation of the primary protein regulator of mitochondrial fission, Dynamin-related Protein 1 (Drp1), has been implicated as an underlying mechanism associated with excessive fission and neurodegeneration; however, whether dysregulation of Drp1 and excessive fission occur …
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The Roles of Midzone and Peripheral Mitochondrial Fission in Pulmonary Arterial Hypertension
… fission is mediated by the large GTPase, dynamin-related protein 1 (Drp1), which upon posttranslational activation translocates near the mitochondrial outer membrane (OMM) where it binds partner proteins of the OMM (Mid49, MiD51, MFF and Fis1) creating the fission apparatus that divides …
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Preclinical Investigation of Mitochondrial Fission Inhibitors in Pulmonary Arterial Hypertension and Non-Small Cell Lung Cancer
Background: Dynamin-related protein 1 (DRP1)-mediated mitochondrial fission is coordinated with nuclear division. This phenomenon, known as mitotic fission, is increased in hyperproliferative diseases, such as non-small cell lung cancer (NSCLC) and pulmonary arterial hypertension (PAH), due to …
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The Role of FAM21 in the Regulation of Mitochondrial Dynamics
… cytoskeleton machinery, including the actin-related protein 2/3 (Arp2/3)-complex, have been implicated at different stages of the complex multi-step mechanism of mitochondrial division. Recent work has also highlighted the contribution of phosphatidylinositol 4-phosphate (PI4P) trafficking, …
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Untersuchungen zum Zusammenhang zwischen mitochondrialer Morphologie, Alterung und Apoptose in Saccharomyces cerevisiae
… Mdm30 (mitochondrial distribution und morphology protein 30), einem Regulator des mitochondrialen Fusionsproteins Fzo1 (fuzzy onions homolog 1), zu einer eingeschränkten Sporulationseffizienz sowie zu mitochondrialen Vererbungsdefekten in den einzelnen Sporen führt. Des Weiteren zeigten die …
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Mitochondrial Dynamics: Exploring A Novel Target Against Myocardial Ischemia-Reperfusion Injury
… mitochondrial health and functional integrity. Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission. Recent studies suggest that i) mitochondrial dynamics, particularly, mitochondrial fission, serves as a mediator of cell fate in the setting of ischemia-reperfusion (IR) …
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Regulation of Mitochondrial Morphology by ERK1/2-Mediated Control of Mfn2 Stability
… 1(Mfn1), Mitofusin 2(Mfn2), Optic atrophy protein 1(Opa1), Dynamin related protein 1(Drp1), Fission protein 1(Fis1) 등의 미토콘드리아 형태조절 단백질(mitochondria-shaping protein)이 관여하는 미토콘드리아 융합-분열 기구(mitochondrial fusion-fission machinery)에 의해 정교하게 조절되고 있다. 이러한 형태조절 단백질들이 어떻게 분자 수준에서 조절 되어 그들의 역할을 …
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The role of mitochondria in regulating smooth muscle cell proliferation and migration in pulmonary hypertension
… inhibition was studied using mitochondrial dynamin-related protein-1 (DRP1) inhibitor Mdivi-1 (10 μM). The signalling proteins and genes were measured by Western blot and real-time qPCR techniques, respectively. Mitochondrial functions were assessed by measuring ATP level, reactive oxygen …
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Investigating the function of PINK1 in cancer development and pathogenesis
… the expression profile of cell cycle associated protein. In addition, PINK1‐deficient MEFs were found to resist cell cycle exit, with a proportion of cells remaining in proliferative phases upon removal of serum. The ability of cells to progress through mitosis conferred by PINK1 expression was …