Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Dynamin 2"”.
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Genetic Dissection of Synaptic Vesicle Endocytosis
… A key protein in this recycling process is dynamin. Dynamin is a GTPase that catalyzes the scission of a budding endosome off its parent membrane. The mammalian brain expresses three isoforms of dynamin. Using genetically modified mouse hippocampal neurons, I analyzed the functional …
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Analysis of the Interaction and Functional Determinants of Arc and Its Regulation of Dynamin
… may be mediated by its reported interaction with dynamin 2, a large (~100 kDa) GTPase that participates in receptor-mediated endocytosis, actin polymerization, and microtubule stabilization. The effects of Arc on dynamin activities have not been characterized. Therefore, I have purified …
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CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… endothelium is compartmentalized in caveolae, c) dynamin-2-dependent internalization of caveoale is important for activating redox signaling, and d) caveolae compartments can be targeted to reduce endothelial ROS Methods and results: Cultured primary bovine aortic endothelial cells were stimulated …
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The Role of Adaptor Protein Grb2 in Ecotropic Retrovirus Entry and Receptor Trafficking
… ligase Cbl to mCAT-1 and the translocation of dynamin 2, which are both binding partners of Grb2. Taken together, these findings suggest an essential role for Grb2 in ecotropic MLV entry and infection by facilitating mCAT1 trafficking. My work not only elucidates an important aspect of the …
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Characterisation of new factors regulating mitochondrial dynamics and cellular metabolism
… this process. Lastly, the controversial role of Dynamin 2 regulating fission was investigated across different cell lines.
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Analysis of Cellular Factors Involved in Adeno-Associated Virus Type 2 Entry
… were enriched in activated PKC alpha, actin and dynamin. Treatment with dynosore, expression of dominant negative dynamin 2, or an HSPG construct lacking the PKC recruitment domain greatly diminished the size of macropinosomes and AAV internalization. Finally, silencing of clathrin heavy chain by …
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Regulation of autophagosome formation and maturation by neurodegeneration-associated proteins
… transport (ESCRT) complex and then released by dynamin 2 (DNM2) before fusing with lysosomes to enable the degradation of the autophagy substrates. Impaired autophagic clearance is a shared hallmark of neurodegenerative diseases and exacerbates neurodegeneration. I aimed to investigate how …
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Muscle disorder or metabolic disorder: genomic, transcriptomic, and metabolomic insights into the pathogenesis of wooden breast and white striping in commercial broiler chickens
… in inflammation and immune response, and dynamin 2 (DNM2), involved in biphasic insulin secretion and associated with two congenital neuromuscular diseases in humans. ☐ Collectively, this dissertation frames the pathogenesis of wooden breast and white striping as closely related metabolic …
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The Roles of Midzone and Peripheral Mitochondrial Fission in Pulmonary Arterial Hypertension
… fission is mediated by the large GTPase, dynamin-related protein 1 (Drp1), which upon posttranslational activation translocates near the mitochondrial outer membrane (OMM) where it binds partner proteins of the OMM (Mid49, MiD51, MFF and Fis1) creating the fission apparatus that divides …