Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"Dynamic contrast enhanced-MRI"”.
-
Analysis of dynamic contrast enhanced MRI datasets
… research is to perform automated analysis of 4D dynamic contrast enhanced MRI datasets (DCE-MRI) of the habd and wrist relating to rheumatoid arthritis (RA) studies. In DCE-MRI, sequences of images are acquired from the joints over time, during which a contrast agent pre-injected into a patient …
-
Dynamic contrast-Enhanced MRI of Pancreatic Islet Transplants
… on intravascular injection of a FDA-approved contrast agent which leaks from and accumulates around permeable immature blood vessels. Rapidly acquired MRI scans following contrast administration can then show the location and extent of new vessel formations. Our studies showed dynamic …
-
Towards image registration of dynamic contrast enhanced MRI using deep learning
Dynamic contrast enhanced (DCE)-MRI is a quantitative imaging technique used to monitor microvascular perfusion. It involves rapidly acquiring multiple T1-weighted images over a few minutes whilst injecting a contrast agent, which causes a rapid increase in image intensity. Each type of tissue …
-
Dynamic Contrast-Enhanced MRI and Diffusion-Weighted MRI for the Diagnosis of Bladder Cancer
… study is aimed at evaluating the abilities of 3T dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DWI) to improve the detection and staging and to enable the prediction of chemotherapeutic response in bladder cancer. A total of fifty-three patients were enrolled in the study. …
-
Alignment of contrast enhanced medical images
… of medical images in which there are multiple contrast variations is difficult. The reason for this is that the popularmeasures of image similarity used to drive the alignment procedure do not separate the influence of intensity variation due to image feature motion and intensity variation due …
-
Combination therapy studies with the vascular disruptive agent combretastatin-a4-phosphate (CA4P)
… evaluated heterogeneity of blood flow related dynamic contrast enhanced MRI (DCE-MRI) parameters between different patients and in lesions within patients on the A5B7 study. Increases in CO (mean +14%, p=0.026) occurred after CA4P whilst falls in tumour Ktrans values were seen (mean -25.1%; …
-
Functional Imaging to enable more accurate localisation and characterisation of prostate tumours
… patient management. Recently, multiparametric MRI has revolutionised the work-up of prostate cancer, becoming a routine part of clinical practice and migrating earlier in the diagnostic pathway. However, the technique remains challenging, with patient-related factors, intrinsic insensitivity of …
-
Effect of Acute Administration of Angiopoietin-1 In Experimental Traumatic Spinal Cord Injury: Magnetic Resonance Imaging and Neurobehavioral Studies
… Using longitudinal magnetic resonance imaging (MRI) studies (dynamic contrast-enhanced [DCE]-MRI for quantification of BSCB permeability, highresolution anatomical MRI for calculation of lesion size, and diffusion tensor imaging for assessment of axonal integrity), the acute, subacute, and …
-
Blood-Brain Barrier Permeability and Inflammation in Cerebral Small Vessel Disease
… A PET/MR system was used to acquire simultaneous dynamic contrast enhanced MRI with Patlak modelling to measure BBB leakage, and [C11]PK-11195 PET to assess microglia activation. We recruited 20 sporadic SVD patients, 20 monogenic SVD patients (CADASIL) and 20 healthy controls to this study. …
-
Functional Magnetic Resonance Imaging of Breast Cancer
… examines the use of magnetic resonance imaging (MRI) techniques in the detection of breast cancer and the prediction of pathological complete response (pCR) to neoadjuvant chemotherapy (NACT). This thesis compares the diagnostic performance of diffusion-weighted imaging (DWI) models in the breast …
-
Mechanisms of vascular cognitive impairment in cerebral small vessel disease and stroke
… focusses on two longitudinal studies, the ‘PET-MRI-SVD’ and ‘Rates, risks and routes to reduce vascular dementia’ (R4VaD), which involved a CSVD (n = 77) and stroke (n = 201) cohort respectively. Multimodal neuroimaging data were acquired in both studies, including structural magnetic resonance …
-
Integrated Multimodal Analysis: Evaluating the Impacts of Chemotherapy and Electroporation-Based Therapy on Lymphatic and Blood Microvasculature in Cancer
… of lymphatic and blood microvascular dynamics in a 4T1 breast cancer mouse model treated with sub-ablative H-FIRE, 3) through the development of a novel habitat imaging method to identify treatment specific changes in the tumor draining lymph node, and the development of a hybrid …
-
Imaging Metabolic Signatures in High Grade Serous Ovarian Cancer
… but not with [<sup>18</sup>F]FDG PET. Dynamic Contrast Enhanced MRI measurements showed that the metabolic differences between the subtypes were not due to differences in tumour perfusion. I also investigated whether differences in tumour metabolism could help to predict and detect …
-
The analysis of dynamic contrast-enhanced magnetic resonance imaging data: treatment effects, sampling rates and repeatability
This dissertation describes the analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data, primarily by means of pharmacokinetic models, in order to yield parameters which reflect the physiological properties of tumours. Historically, these analysis procedures have been …
-
Novel multi-parametric, multi-modality imaging for the assessment of tumour biology in renal cell carcinoma
… investigated morphological and physiological 1H-MRI to detect early response and predict outcome. Multiparametric MRI demonstrated physiological changes after 12 days of anti-vascular therapy, which were compatible with its mechanism of action. The reduction in tumour diffusivity correlated with …
-
Integration of Biomedical Imaging and Translational Approaches For Management of Head and Neck Cancer
… be successfully used to adapt RT dose based-on dynamic tumor response, predict oncologic disease outcomes, characterize RT-induced toxicity, and identify the patterns of disease failure. We used anatomical MRIs for the RT dose adaptation purpose. Our findings showed that after proper …