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Showing 1 to 6 of 6 for “"Dynamic combinatorial chemistry"”.
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Dynamic combinatorial synthesis of donor-acceptor catenanes
Dynamic combinatorial chemistry (DCC) is a powerful method for synthesising complex molecules and identifying unexpected receptors. Chapter 1 gives an overview of the concept of DCC and its applications, and discusses its evolution to date. Chapter 2 describes the discovery of a new generation of …
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Towards novel luminescent probes for monitoring β- galactosidase activity
… suitable substrates for the enzyme, a dynamic combinatorial chemistry approach was also explored. This used disulfide bonds to attach the naphthyl moiety to the methyl glucoside using linkers of different lengths. From this library, the enzyme successfully processed the novel disulfide …
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Characterization of a Novel Dynamic Combinatorial Depsipeptide System with Implications for the Origin of Biopolymers
… a kinetic limitation that strongly inhibits dynamic sequence space sampling for peptides and proteins even in modern-day laboratory applications. This hardened chemical nature of proteins suggests that although their constituent amino acids may have been available in prebiotic times, proteins …
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Non-Covalent Interactions in Water Using Synthetic and Biological Receptors
… aromatic side-walls of the receptor. The thermodynamic contribution of these aromatic interactions to the overall stability of the complex has been quantified by chemical double mutant cycles using isothermal titration calorimetry and <sup>1</sup>H NMR competition experiments. In chloroform, the …