Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Dynamic Combinatorial"”.
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Dynamic combinatorial synthesis of donor-acceptor catenanes
Dynamic combinatorial chemistry (DCC) is a powerful method for synthesising complex molecules and identifying unexpected receptors. Chapter 1 gives an overview of the concept of DCC and its applications, and discusses its evolution to date. Chapter 2 describes the discovery of a new generation of …
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Characterization of a Novel Dynamic Combinatorial Depsipeptide System with Implications for the Origin of Biopolymers
… a kinetic limitation that strongly inhibits dynamic sequence space sampling for peptides and proteins even in modern-day laboratory applications. This hardened chemical nature of proteins suggests that although their constituent amino acids may have been available in prebiotic times, proteins …
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Set-based Particle Swarm Optimisation for Dynamic Optimisation Problems
… real-world optimisation problems are inherently dynamic, defined by changes in their underlying properties over time. Real-world problems also frequently require optimisation over discrete-valued decision variables. However, the solution of problems that are simultaneously dynamic and …
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Towards novel luminescent probes for monitoring β- galactosidase activity
… suitable substrates for the enzyme, a dynamic combinatorial chemistry approach was also explored. This used disulfide bonds to attach the naphthyl moiety to the methyl glucoside using linkers of different lengths. From this library, the enzyme successfully processed the novel disulfide …
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Ant Colony Optimisation for Dynamic and Dynamic Multi-objective Railway Rescheduling Problems
… This will change the problem, making it a dynamic problem that changes over time. The aim of this work is to investigate the application of ant colony optimisation (ACO) to dynamic and dynamic multiobjective railway rescheduling problems. ACO is a promising approach for dynamic …
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Kinetic and structural evolution of functional peptide assembling networks
… of assembly are synthesized and selected via the dynamic combinatorial networks (DCNs), which yield sequence-defined oligomers with high fidelity. Both experimental analyses and mathematical modeling are applied to confirm the interplay between the chemical distribution and emergent physical …
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Non-Covalent Interactions in Water Using Synthetic and Biological Receptors
… aromatic side-walls of the receptor. The thermodynamic contribution of these aromatic interactions to the overall stability of the complex has been quantified by chemical double mutant cycles using isothermal titration calorimetry and <sup>1</sup>H NMR competition experiments. In chloroform, the …
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Computational Techniques Applied to RNA Structures and Bacterial Genomes
Modern molecular biology studies increasingly require customized computation support. This is especially true for studies associated with atomic resolution structures and/or NextGen sequencing. In this dissertation, three separate studies are described in which modern computational methodologies …