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Showing 1 to 3 of 3 for “"Dye leakage assay"”.
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Synthesis and dye leakage assay of human and rat islet amyloid polypeptide 10-19 and insulin 14-18
… 10-19 to disrupt membranes was tested using a dye leakage assay. The fluorescence of the peptide was measured in increasing concentrations to determine whether their ability to cause cell death is concentration dependent or not. While the rate of membrane disruption stayed constant, it was …
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Role of aromatic pi-stacking on the aggregation of human islet amyloid polypeptide (hIAPP)
… differently charged lipids, using a fluorescent dye leakage assay. Both modified hIAPP 1-19 sequences were found to be less active when compared to the original hIAPP 1-19 sequence. This might be due to lack of aromatic pi-stacking interactions at the 15th position or due to inappropriate …
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Experimental simulation of human islet amyloid polypeptide (hIAPP)-pancreatic beta cell membrane interactions: Inferences and implications in the etiopathogenesis of diabetes mellitus type II
<p>Pancreatic beta cells secrete insulin, an endocrine hormone that regulates blood glucose levels and maintains normal physiological activity in humans and animals. Diabetes mellitus type II is a consequence of the gradual destruction of these important cells, likely by human islet amyloid …