Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Dupilumab"”.
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Determinants of systemic treatment response in atopic dermatitis
… effectiveness, safety, and drug survival of dupilumab and ciclosporin. Dupilumab showed superior drug survival, a favorable safety profile, and sustained clinical effectiveness under real-life conditions. To extend these findings to pediatric patients, interim data from the TREATkids registry …
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Az atópiás dermatitis legújabb szisztémás kezelési lehetőségei
… csoportjába tartozó monoklonális antitestek, a dupilumab és a tralokinumab. Az AD patomechanizmusának egy kulcsfontosságú része az IL-4 és IL-13 citokinek upregulátiója és a hozzájuk kapcsolódó gyulladásos immunválasz kialakulása és fennmaradása. A dupilumab mindkét útvonalat képes gátolni az …
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Investigating the regulatory mechanisms of allergen-specific IgG4 production
… (AIT) and monoclonal antibodies (Omalizumab and Dupilumab) aim to reduce symptoms but are not curative and require ongoing treatment. Emerging research suggests that IgG4 antibodies, which increase with chronic allergen exposure and AIT, play a protective role by competing with IgE to prevent …
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Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis
… targeting IL-4/IL-13 signalling axis with dupilumab show efficacy in AD. We investigated the importance of interleukin 4 receptor alpha (IL- 4Rα) signalling specifically on B and T cells to understand the requirement of this signalling axis in epicutaneous skin sensitisation during AD. We …