Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"Ductal carcinoma"”.
-
Identification and characterisation of non-coding RNAs involved in ductal carcinoma in situ
Ductal carcinoma in situ (DCIS) is an early form of breast cancer, the most common cancer in women worldwide. DCIS can develop into potentially fatal invasive disease, but studies show that less than half of all cases progress if untreated. Currently, most patients receive surgery, as there is no …
-
Investigating Invasion In Ductal Carcinoma In Situ With to pographical Single Cell Genome Sequencing
<p>Synchronous Ductal Carcinoma in situ (DCIS-IDC) is an early stage breast cancer invasion in which it is possible to delineate genomic evolution during invasion because of the presence of both in situ and invasive regions within the same sample. While laser capture microdissection studies of …
-
Analysis of gene expression alterations in premalignant progression from normal mammary epithelium to ductal carcinoma in situ by multiple orthogonal tools
<p>Mammary ductal carcinoma in situ (DCIS) is being found in great numbers of women due to the widespread use of mammography. The molecular and genetic changes underlying the progression from normal breast tissue to DCIS are not clearly understood. The goal of the present study was to determine …
-
Investigation of Genetic Alterations In Emt Suppressor, Dear1, Through Pan-Cancer Analysis and Ultra-Deep Targeted Sequencing In Ductal Carcinoma In Situ
<p>Ductal carcinoma in situ<strong> (</strong>DCIS) is thought to be one of the earliest pre-invasive form of and non-obligate precursor to invasive ductal carcinoma (IDC). There is an urgent need to identify predictive and prognostic biomarkers for breast cancers with a heightened risk of …
-
Krūties carcinoma in situ tipai, diagnostika, gydymas ir prognozė /
SUMMARY Carcinoma in situ is a non-invasive form of breast cancer characterised by abnormal cell growth in the ducts or lobules of breast tissue. Breast carcinoma in situ consists of two subtypes: ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS). Breast carcinoma in situ is most …
-
Deciphering Genomic Evolution: From Early Breast Cancer Stages to Invasive Carcinoma
This dissertation investigates the evolution of ductal carcinoma in situ (DCIS) to invasive forms such as invasive ductal carcinoma (IDC) at the individual patient level. DCIS is considered a non-obligatory precursor of IDC, being the predominant form of breast cancer detected and comprising …
-
The Role of Tumor Suppressor Dear1 In The Acquisition of Mammary Stem/Progenitor Cell Properties
… commonly diagnosed cancer in women in America. Ductal carcinoma <em>in situ</em> (DCIS), one of the earliest pre-invasive forms of invasive ductal carcinoma (IDC), has a 30-50% risk of progressing to IDC. Understanding the mechanisms regulating progression from DCIS to IDC would help identify …
-
Evidence of Human Endogenous Retrovirus K Involvement In Human Cancer
… samples from invasive breast cancer (N=19), ductal carcinoma</p> <p><em>in situ </em>(N=13), malignant ovarian cancer (N=12), and benign ovarian tumors (N=9), via IRB-approved and informed consent protocols through M.D. Anderson Cancer Center, as well as normal donor plasmas purchased from …
-
BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY
… and metastasis is not well understood. Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer which could progress to or recur as invasive breast cancer. To identify the novel regulators of DCIS progression, we performed gene expression analysis of syngeneic cell lines …
-
High-speed polarization-sensitive optical coherence tomography: toward intraoperative cancer imaging
… indistinguishable fibrous stroma and invasive ductal carcinoma (IDC).
-
Identifying Tumor Vascular Permeability Heterogeneity Using Reduced Encoding Techniques
… ve can statistically differentiate invasive ductal carcinoma from non-invasive papillary carcinoma for the 469 mum and 938 mum resolution, p = 0.0017 and p = 0.0047, respectively, but not for 2500 mum resolution, p = 0.9008."
-
Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma
… be of importance in the response to acidic pH in ductal carcinoma in situ (DCIS). We have found that STAT1-directed signaling is up-regulated in response to acidic pH extracellularly. Its role in altering glycolytic pathways suggests an important role for this transcription factor in the …
-
Cooperative Genomic Events Driving Mutant TP53-Driven DCIS Progression
<p>Ductal carcinoma in situ (DCIS) is a mammary lesion characterized by abnormal epithelial cells occurring in mammary ducts while still being confined to the luminal space. Not all DCIS becomes invasive, and no strategy currently exists in patients to stratify indolent DCIS from DCIS at risk of …
-
Decoding Breast Cancer Development Through Single Cell and Spatial Genomics
<p>Ductal carcinoma in situ (DCIS) is a preinvasive breast cancer in which cancer cells remain confined within the lumen of ducts. With the adoption of mammography, DCIS diagnoses have risen significantly, with approximately 50,000 new cases each year in the U.S. While 10-30% of DCIS patients …
-
Krūties vėžio magnetinio rezonanso vaizdo tekstūros analizė /
… data from 42 patients diagnosed with invasive ductal carcinoma was performed. The cohort was evenly split between patients with BRCA gene mutations and those without. The process involved the segmentation of tumors on magnetic resonance images and the extraction of radiomic features using “Olea …
-
Comparison of 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (18F-FDG PET/CT) and conventional imaging (CI) for locally advanced breast cancer staging: a prospective study from a tertiary hospital cancer centre in Western Cape
… locally advanced non-inflammatory infiltrating ductal carcinoma of the breast. Use of 18F-FDG PET/CT was superior to conventional imaging in assessing metastatic mediastinal lymphadenopathy, but with a poor specificity. The use of 18F-FDG PET/CT in LABC is useful, with the biopsy of isolated …
-
Cancer Cartography: Mapping Cancer Evolution in Tissue Space
… various stages of breast cancer, including carcinoma in situ, invasive cancer, and lymph node metastasis reveal clone-specific variations in proliferation, morphology, stroma, hypoxia, and immune microenvironments. In one instance involving ductal carcinoma in situ, polyclonal neoplastic …
-
Finding Common Ground to Treat Primary and Metastatic Cancer: The Potential of Targeting Tumor Stroma
Primary carcinomas and metastases are complex organ-like structures composed of malignant parenchymal epithelial tissues and a desmoplastic stroma formed by accumulation of hematopoietic cells, mesenchymal stromal cells and extracellular matrix. The crosstalk between malignant epithelial cells and …
-
The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics
… proteins (DEPs) between CS and CR invasive ductal carcinoma samples, using 2-dimensional polyacrylamide gel electrophoresis (2D-PAGE) with MALDI-TOF/TOF mass spectrometry and antibody microarray analysis. DEPs were submitted to Ingenuity Pathway Analysis (IPA) to identify any canonical …
-
An investigation into the role of TBX3 in breast carcinogenesis and its regulation by the TGF-?1 signalling pathway
… either (1) stably silenced in an invasive breast ductal carcinoma cell line (MCF-7) which was previously shown to overexpress TBX3 or (2) overexpressed in a normal human breast epithelial cell line (MCF-12A). The resultant cells were then compared to control cells and tested for key …
Page 1 of 2