Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Ductal Carcinoma In Situ"”.
-
Identification and characterisation of non-coding RNAs involved in ductal carcinoma in situ
Ductal carcinoma in situ (DCIS) is an early form of breast cancer, the most common cancer in women worldwide. DCIS can develop into potentially fatal invasive disease, but studies show that less than half of all cases progress if untreated. Currently, most patients receive surgery, as there is no …
-
Investigating Invasion In Ductal Carcinoma In Situ With to pographical Single Cell Genome Sequencing
<p>Synchronous Ductal Carcinoma in situ (DCIS-IDC) is an early stage breast cancer invasion in which it is possible to delineate genomic evolution during invasion because of the presence of both in situ and invasive regions within the same sample. While laser capture microdissection studies of …
-
Analysis of gene expression alterations in premalignant progression from normal mammary epithelium to ductal carcinoma in situ by multiple orthogonal tools
<p>Mammary ductal carcinoma in situ (DCIS) is being found in great numbers of women due to the widespread use of mammography. The molecular and genetic changes underlying the progression from normal breast tissue to DCIS are not clearly understood. The goal of the present study was to determine …
-
Investigation of Genetic Alterations In Emt Suppressor, Dear1, Through Pan-Cancer Analysis and Ultra-Deep Targeted Sequencing In Ductal Carcinoma In Situ
<p>Ductal carcinoma in situ<strong> (</strong>DCIS) is thought to be one of the earliest pre-invasive form of and non-obligate precursor to invasive ductal carcinoma (IDC). There is an urgent need to identify predictive and prognostic biomarkers for breast cancers with a heightened risk of …
-
Krūties carcinoma in situ tipai, diagnostika, gydymas ir prognozė /
SUMMARY Carcinoma in situ is a non-invasive form of breast cancer characterised by abnormal cell growth in the ducts or lobules of breast tissue. Breast carcinoma in situ consists of two subtypes: ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS). Breast carcinoma in situ is most …
-
BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY
… health problem worldwide. However, the underlying molecular mechanism of breast cancer progression and metastasis is not well understood. Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer which could progress to or recur as invasive breast cancer. To identify the novel …
-
Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma
… peritumoral pH. The first objective was to determine if an acidic extracellular pH observed in vivo (i.e., pHe 6.8) affects the activity of proteases, such as cathepsin B, that contribute to degradation of collagen IV by tumor cells when grown in biologically relevant three-dimensional cultures. …
-
Cooperative Genomic Events Driving Mutant TP53-Driven DCIS Progression
<p>Ductal carcinoma in situ (DCIS) is a mammary lesion characterized by abnormal epithelial cells occurring in mammary ducts while still being confined to the luminal space. Not all DCIS becomes invasive, and no strategy currently exists in patients to stratify indolent DCIS from DCIS at risk of …
-
Decoding Breast Cancer Development Through Single Cell and Spatial Genomics
<p>Ductal carcinoma in situ (DCIS) is a preinvasive breast cancer in which cancer cells remain confined within the lumen of ducts. With the adoption of mammography, DCIS diagnoses have risen significantly, with approximately 50,000 new cases each year in the U.S. While 10-30% of DCIS patients …
-
Cancer Cartography: Mapping Cancer Evolution in Tissue Space
… to cancer development, significant gaps in understanding persist. These gaps concern the role of cellular interactions within the tumour microenvironment (TME) and the impact of spatial constraints on cancer evolution. Emerging spatial omics technologies offer the potential to address …
-
The Role of TBX3 In Early Breast Cancer Progression
TBX3 is a transcriptional regulator involved in embryonic development and in tumorigenesis of several cancer types. There are two isoforms of TBX3 (TBX3iso1 and TBX3iso2) with different DNA binding domains. The large-scale functional roles of TBX3iso1 and TBX3iso2 were characterized in a breast …
-
Deciphering Genomic Evolution: From Early Breast Cancer Stages to Invasive Carcinoma
This dissertation investigates the evolution of ductal carcinoma in situ (DCIS) to invasive forms such as invasive ductal carcinoma (IDC) at the individual patient level. DCIS is considered a non-obligatory precursor of IDC, being the predominant form of breast cancer detected and comprising …
-
Human Endogenous Retrovirus K As A Novel Tumor-Associated Antigen For Development of An Ovarian Cancer Vaccine
… ANTIGEN FOR DEVELOPMENT OF AN OVARIAN CANCER VACCINE </strong><em></em></p> <p>Publication No.________<br />Kiera Rycaj, B.S.<br />Supervisory Professor: Feng Wang-Johanning, Ph.D., M.D.</p> <p>Ovarian cancer (OC) is the fourth most common cancer in women, and the most lethal gynecologic …
-
Computational Approaches to Understand Chemoresistance & Tumor Evolution Using Longitudinal Clinical Data and Lineage Tracing
… are highly heterogeneous and dynamic, continually adapting and evolving in response to their microenvironment as well as external perturbations. Multi-region (spatial) and single cell sequencing has enabled us to anatomize the heterogeneity further and provide evidence of its association …
-
Ipsilateral and concurrent breast cancer and atypical ductal hyperplasia: Does atypia also need surgical excision?
… excision. Research efforts have focused on utilizing strict multidisciplinary review to identify patients at lowest risk for upgrade that may benefit from omission of surgery. However, having an ipsilateral breast cancer, in addition to the site of ADH, has been an exclusion criterion for …
-
Investigating The Ecology and Evolution of Normal Breast Tissues and Breast Cancer With Single Cell Genomics
<p>There is vast cellular heterogeneity in human breast tissues, with different transcriptional programs in the stromal, epithelial, and immune components, however, it remains unclear how their reprogramming and interplay leads to the progression of invasive phenotypes such as Triple- Negative …
-
Ursolic acid and oleanolic acid as novel therapeutic agents in breast cancer
… is one of the most common cancers among women in South Africa and the second leading cause of cancer death after lung cancer. According to the American Cancer Society 2015, women have a 12% chance of developing invasive breast cancer and a 3% chance of dying from it. Despite the wide variety of …
-
ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
… and overall lipogenesis have been reported in a wide variety of cancers and blocking the lipogenic pathway by chemical inhibitors or RNA interference causes tumor cell death by apoptosis which provides a strong rationale for targeting lipogenic pathway for the treatment and prevention of …
-
DEVELOPMENT OF AN IN VIVO MULTITASKING BIOLUMINESCENT REPORTER GENE PLATFORM FOR THE PRECLINICAL EVALUATION OF RNA THERAPEUTICS
… have emerged as a transformative class of medicines, enabling precise modulation of gene expression through sequence-defined mechanisms and offering novel therapeutic opportunities for previously intractable diseases. The potential of these drugs to address unmet pharmacological needs, together …