Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 247 for “"Ductal"”.
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Regulation of CYP3A5 in Pancreatic Ductal Adenocarcinoma
… amounts in some cancers, including pancreatic ductal adenocarcinoma (PDAC). There have been several published studies regarding CYP3A5 regulators, but there is still much to be discovered concerning CYP3A5 regulation in cancer. To further understand the regulation of CYP3A5, a high-throughput …
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T Cell Immunosurveillance in Pancreatic Ductal Adenocarcinoma
ABSTRACT T CELL IMMUNOSURVEILLANCE IN PANCREATIC DUCTAL ADENOCARCINOMA Rebecca A. Evans Robert H. Vonderheide The prevailing theory of cancer immune surveillance, as understood from carcinogen-driven mouse models of highly mutated tumors, states that T cell-mediated immune pressure drives a …
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Heparan Sulfate Proteoglycans in Pancreatic Ductal Adenocarcinoma (PDAC)
… (SDC1), as a key effector for pancreatic ductal adenocarcinoma (PDAC) progression whose surface expression is driven by KRAS*. By leveraging various PDAC models, we found that surface SDC1 expression was initially diminished upon mutant KRAS (KRAS*) signaling blockade but recovered in …
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The mesenchymal regulation of ductal-driven liver regeneration
… when hepatocyte proliferation is compromised, ductal cells become activated into bipotential progenitors to replace lost epithelium. This process can be recapitulated in vitro by growing hepatic ductal cells under defined extracellular matrix and growth factors, which generates 3D epithelial …
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EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
… promoting invasion and metastasis of pancreatic ductal adenocarcinoma (PDA) and immune regulation, through modulation of the activity of regulatory T-cells (Treg), a subset of T-cells that suppress the immune system and maintain immune tolerance. In three common PDA cell lines, AsPC-1, PANC-1, …
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Investigating The Role of Cd109 In Pancreatic Ductal Adenocarcinoma
<p>Pancreatic Ductal Adenocarcinoma (PDAC) is the 3rd leading cause of cancer death in the US. We performed loss of function genomic screening on a cohort of four patient derived PDAC cell populations and our data shows a cell surface receptor CD109 to be a common vulnerability, the biologic role …
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Mechanisms Controlling Ductal Morphogenesis in the Ruminant Mammary Gland
… through the proliferation of highly arborescent ductal structures embedded in a dense stroma. These observations contrast strongly with models of mammogenesis based on murine mammary development. The formation of luminal spaces and the expansion of ducts also differed from murine mammogenesis …
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ZNF300 may influence the metastatic properties in pancreatic ductal adenocarcinoma
… to promote the tumorigenesis of pancreatic ductal adenocarcinoma (PDAC). Moreover, due to the overwhelming number of PDAC patients presented with metastasis at the time of diagnosis, it is necessary to better understand the process of metastasis. To understand the role of DNA methylation may …
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Targeting Cyclin Dependent Kinases 4/6 Activity in Pancreatic Ductal Adenocarcinoma
Pages vi-xiii are incorrectly numbered as pages v-xii.
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Learning from histopathology images: AI-driven biomarkers for pancreatic ductal adenocarcinoma
Contains fulltext : 332320.pdf (Publisher’s version ) (Closed access)
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MRI Radiomics Modeling and Survival Prediction of Pancreatic Ductal Adenocarcinoma Patients
Pancreatic cancer is a particularly lethal and aggressive malignancy characterized by its late detection and 5-year survival of less than 10% for both men and women as of 2022. While many cancers come with symptoms of varying degrees, pancreatic cancer is largely asymptomatic until the disease …
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Tracing clonal cell plasticity in the microenvironment of pancreatic ductal adenocarcinoma
… a vulnerability to cancer through acinar-to-ductal metaplasia and dedifferentiation by epithelial-mesenchymal transition, which contributes in largely unknown ways to metastasis in pancreatic cancer. As with most solid tumours, pancreatic ductal adenocarcinoma develops at the interface of …
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MicroRNAs in Pancreatic Ductal Adenocarcinoma: New Approaches For Better Diagnosis And Therapy
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with less than an 8% 5-year survival rate, which has remained unchanged over the last 50 years. Early detection is particularly difficult due to the lack of disease-specific symptoms and reliable diagnostic …
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Targeting Stromal-Mediated Resistance Mechanisms in Oncogenic KRAS-Driven Pancreatic Ductal Adenocarcinoma
<p>Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with oncogenic KRAS mutations driving both tumor initiation and maintenance. Despite recent breakthroughs in KRAS-targeted therapies, the rapid emergence of resistance mechanisms limits their clinical efficacy. …
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Role of Methyltransferase Like-3 (Mettl3) In Pancreatic Ductal Adenocarcinoma (Pdac) Progression
<p>Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer with about a 10% five-year survival rate. The grim prognostic situation of pancreatic cancer patients underlines the need to identify novel molecular targets. Recent studies have brought to attention, the need to therapeutically …
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Aberrations of A Putative Tumor Suppressor Gene Sel1L In Pancreatic Ductal Adenocarcinoma
… in a significant proportion of human pancreatic ductal adenocarcinoma (PDAC). It was hypothesized that <em>SEL1L</em> expression could be down-modulated by somatic mutation, loss of heterozygosity (LOH), CpG island hypermethylation and/or aberrantly expressed microRNAs (miRNAs).</p> …
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The role of Arid1a and Tet1 in ductal cell-driven liver regeneration
Title: The role of Arid1a and Tet1 in ductal cell-driven regeneration Author: Mikel Alexander Mckie The liver has several robust and potent mechanisms of repair after damage despite slow homeostatic turnover. In cases of extreme toxic damage, where the hepatocyte compartment is severely compromised …
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Identifying genes that are required for the maintenance of pancreatic ductal adenocarcinoma
… important for the maintenance of Pancreatic Ductal Adenocarcinoma (PDAC). PDAC is the 4th leading cause for cancer-related deaths and exhibits a 5-year survival rate of less than 5%. Since PDAC is a Kras-driven cancer in that greater than 90% of PDACs contain a Kras mutation, we tested genes …
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