Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Dual-Specificity Phosphatases"”.
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DUSP5 Regulation of Inflammation and Insulin Signaling
… studies have examined the role for downstream phosphatases in the deactivation (i.e. dephosphorylation) of this pathway. Therefore, I examined a role for the MAPK-specific dual-specificity phosphatases (DUSPs) in the deactivation of MAPK signaling in response to TNF?-mediated inflammation. We …
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Investigation of the action of phosphatase of regenerating liver on PTEN using murine models
… functions to be carried out. Protein kinases and phosphatases are the keepers of this balance with kinases adding phosphate groups and phosphatases removing them. As such, mutation and/or altered regulation of these proteins can be the driving factor in disease. Phosphatase of Regenerating Liver …
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The Role of Dual Specificity Phosphatase -11 In Innate and Adaptive Immune Responses
<p><strong>THE ROLE OF DUAL SPECIFICITY PHOSPHATASE -11 IN INNATE AND ADAPTIVE IMMUNE RESPONSES</strong></p> <p><strong>Kalyan Chakravarthy Nallaparaju, M.S.</strong></p> <p><strong>Supervisory Professor: Chen Dong, Ph.D</strong>.</p> <p>Dual-specificity phosphatases (DUSPs) constitute a subfamily …
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Linking Molecular, Electrical And Anatomical Properties Of Human Epileptic Brain
… MAPK signaling. DUSP4, a member of a family of dual specificity phosphatases function by inhibiting both isoforms of ERK1/2, is one of the most potent inhibitors of MAPK/CREB signaling. DUSP4 was significantly upregulated in high spiking areas, raising an important question as to why both …
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Phosphatase Regulation of Mechanical Stress and Aging in C. elegans
… cellular homeostasis and influence adaptation. Phosphatases represent master regulators of stress signaling and modulate cellular responses and fate during stress and aging. Yet, physiologically relevant mechanisms by which these phosphatases are regulated or orchestrate stress response and …