Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Dual-Ligand"”.
-
Modulation of Endothelial Cell Adhesion to Synthetic Vascular Grafts Using Biotinylated Fibronectin in a Dual Ligand Protein System
… goal of this project was to optimize the dual ligand (DL) system on synthetic vascular graft (SVG) surrogates to show enhanced cell adhesion, retention, and native functionality compared to fibronectin alone. Initially, two SVG surrogates were identified through characterization by x-ray …
-
Design, Synthesis, and Antibacterial Properties of Dual-Ligand Inhibitors of Acetyl-CoA Carboxylase and Mechanism of Action for the Antibacterial Agent Moiramide B
… presented in this dissertation describes dual-ligand inhibitors incorporating selective inhibitors against biotin carboxylase and carboxyltransferase that were synthesized by covalently attaching them with saturated hydrocarbon linkers containing 7 and 15 carbon atoms. The ability to …
-
Ligand-Driven Development of Pd-Catalyzed Nondirected C–H Activation of Arenes
… the common goal of exploring the potential of dual-ligand enabled palladium-catalyzed aromatic C–H activation, this dissertation presents and discusses three research projects. The first project describes the development of a nondirected C–H olefination method for the late-stage installation of …
-
Nondirected C(sp2)–H Activation of (Hetero-)Arenes Through Ligand-Enabled Palladium Catalysis
… of this thesis was the development of innovative ligands for Pd-catalyzed nondirected C–H activation, which enable new reactivities and transformations. The first chapter deals with the historical development of a palladium-based catalyst system consisting of two complementary ligands, which …
-
Exploring Critical Vehicle Parameters for the Design of Multitargeted Nanoparticles for Cancer Specific Gene Delivery
… functionalized with cancer-targeting ligands have shown promise but are still limited by off-tumor binding to healthy tissues that nevertheless express low levels of the molecular target. Targeting two unique cancer biomarkers using dual-targeted heteromultivalent nanoparticles …
-
Improving Palladium Catalyzed C–H Activation Methodologies Towards Industrial Applicability
… the steric properties and reactivity of our dual ligand catalyst, we developed a series of hemilabile ligands. In the second chapter, following the principle of sustainable development, we addressed the replacement of silver with a more environmentally benign oxidant. The advantages of this …
-
Enhancing Stability in Quantum-Dot and Perovskite Optoelectronic Devices through Compositional Engineering and Surface Treatment
… the bulk to focusing on the surface of QDs. A dual-ligand exchange assembles perovskite QDs into a densely-packed, ordered solid, which enhances conductivity and enables LEDs that generate 1000 cd m-2 at a voltage of 2.8 V. The reduced operating field extends the operating device stability …
-
Resveratrol Nanostructured Lipid Carrier for targeted delivery to breast cancer
… it for further functionalization with targeting ligands hyaluronic acid; HA-NLCs, folic acid; FA-NLCs and dual targeting system using both hyaluronic acid and folic acid; HAFANLCs, and optimization of ligand density and quantify the amount of amine groups present on the surface on RES-NLCs. The …