Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Dual Targeting"”.
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Dual Targeting of Tumor Angiogenesis and Chemotherapy By Endostatin- Cytosine Deaminase-Uracil Phosphoribosyltransferase
… vascularformation to suppress tumor growth. Targeting specific VEGF/R has been showntherapeutic benefits in many cancer types and become a first approvedantiangiogenic modalities by Food and Drug Administration (FDA) in United States.However, interruption of homeostasis in normal tissues that …
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DUAL TARGETING OF RFAP AND FIMH IMPAIRS AIEC INTRACELLULAR SURVIVAL AND LIMITS OMV-DEPENDENT IL-23/PTH17 AXIS ACTIVATION, OFFERING A NOVEL THERAPEUTIC STRATEGY FOR CROHN¿S DISEASE
… the exaggerated inflammation without directly targeting AIEC, and the only AIEC-based approach under investigation is the inhibition of FimH, which mediates adhesion to intestinal epithelial cells. However, whether FimH inhibitors also affect other key steps of AIEC-host interaction, such as …
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ECLIPSED DUAL DISTRIBUTION OF MITOCHONDRIAL PROTEINS IN EUKARYOTES: UBIQUITINATION IN YEAST MITOCHONDRIA AS A PARADIGM
… studies of Ophry Pines' lab demonstrate that dual targeting of mitochondrial proteins is a highly abundant phenomenon using Saccharomyces cerevisiae as the model organism. The studies of the present thesis indicate that a significant fraction of cellular proteins, much more than previously …
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Development of PAC-1 as a privileged agent for combination chemotherapy
… enabled a proof-of-concept evaluation of dual targeting of a single protein with small-molecule activators. Synergistic enhancement in protein activity, signaling pathway activation and in vivo efficacy were observed. This substantiated the hypothesis that when orthogonal mechanisms of …
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Expanding cancer therapy options through genome-scale identification of synthetic lethal paralogs
… of context-dependent gene essentiality in which dual inactivation of a gene pair leads to cell death but single-gene inactivation does not affect viability. When one synthetic lethal gene is inactivated in cancer, targeting the remaining gene results in tumor cell death while normal cells remain …
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The Role of Substance P in Opioid Induced Reward
… a positive CPP score. These data indicate dual targeting of the dopamine reward circuitry and pain pathways with multifunctional opioid-NK₁R compounds may be an effective strategy in developing future analgesics that lack the potential for abuse.
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Efficacy of Dual Cd19-Cd79B Car In B-Cell Malignancies
… with B-cell malignancies relapse following CD19-targeting chimeric antigen receptor (CAR) T cell therapy. CD19 loss is a major cause of relapse and resistance after CD19 CAR T therapy. Dual antigen targeting could overcome resistance due to antigen escape and improve outcomes after CAR T cell …
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The dual-targeted membrane assembly of the <i>Streptomyces coelicolor</i> Rieske protein
… <i>Streptomyces coelicolor</i> Rieske protein is dual targeted to the cytoplasmic membrane since it requires both the Sec and Tat export pathways for correct insertion.<br/><br/>The aim of this study was to investigate this dual-targeting mechanism and to understand the specific features of Rieske …
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The development of functionalised stapled peptides as chemical tools to modulate biological processes in platelets and as novel antimicrobial therapeutics targeting Pseudomonas aeruginosa
… enable infection-controlled drug-release and dual-targeting of P. aeruginosa.
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
… to target PC cells and CA-PSCs, representing a dual targeting approach. Our data supports the concept of personalised medicine in which a patient will be treated based on their tumour’s genetic/metabolic profile, overcoming the current ‘one-drug-fits-all’ approach. Importantly, our findings …
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Studies Towards a Second-Generation Synthesis of the Aplyronines
… profile, acting through an actin and tubulin dual-targeting mechanism, with subnanomolar growth inhibitory potency against a diverse range of cancer cell lines. These characteristics render the aplyronines ideal payloads for antibody-drug conjugates but their prohibitively low natural …
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Mechanism of Resistance in Common Ragweed to PPO-inhibiting Herbicides
… which was due to a single codon deletion in a dual-targeting gene known as PPX2L. Common ragweed, from Delaware, was the third documented weed species that evolved PPO-inhibiting herbicide resistance. This thesis provides information on the resistance mechanism of this common ragweed biotype to …
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Exploring Critical Vehicle Parameters for the Design of Multitargeted Nanoparticles for Cancer Specific Gene Delivery
… encapsulating siRNA were functionalized with a targeting peptide which binds to the alpha6 integrin, a cervical cancer biomarker. It was found that both targeting and polymer complexation before encapsulation were critical components to effective transfection. Varying the siRNA:polymer ratio …
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Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma
… for pancreatic cancer by simultaneously targeting pancreatic cancer cells and the stroma. In Chapter 1, we briefly introduce the background of the dissertation research and present the Statement of the Problems and Objectives. In Chapter 2, we review the epidemiology of pancreatic cancer …
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Polyomavirus Enhancer Activator 3 (PEA3), a Member of the Ets Family of Transcription Factors, Is a Transcriptional Activator of Notch-1 and Notch-4 in Breast Cancer: An Opportunity for Novel Combinational Therapy
… of MDA-MB-231 breast cancer cells. Thus, dual targeting of both PEA3 and Notch pathways might provide a new therapeutic strategy for triple-negative breast cancer as well as additional therapeutic targeting in other breast cancer subtypes.</p>
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Identification of Trim24 Domain Essentiality In Primary Trim24Coe Carcinosarcoma Cell Lines
… Therefore, there is a growing interest in targeting these control mechanisms for their potential therapeutic values.</p> <p>Our lab previously discovered the epigenetic regulator function of Tripartite motif protein 24 (TRIM24) through its H3K4me0 and H3K23ac dual histone signature reader …
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Transcriptomic study of evolution and gene expression in diploid and allotetraploid glycine subgenus glycine
… of soybean BolA4-like protein suggested a dual targeting nature between chloroplast and mitochondria. A similar BolA protein in Arabidopsis thaliana has been implicated in the mediation of redox homeostasis. Changes in distribution of this BolA4-like protein due to the 24-base-pair deletion …
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Resveratrol Nanostructured Lipid Carrier for targeted delivery to breast cancer
… carrier allow encapsulation of drug and targeting of desired tissue. Resveratrol (RES) is a chemotherapeutic drug limited by its physiochemical properties (i.e. poor solubility and bioavailability), encapsulation into NLCs is potentially viable solution to the aforementioned issues. Aim: …