Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Dry eye disease"”.
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Evaluating the Role of the Ocular Surface Microbiome in Dry Eye Disease Mediated Neural Dysregulation
Dry eye disease (DED) is a multifactorial ocular surface disorder arising from a loss of homeostasis at the corneal-tear interface. This leads to visual and neurosensory abnormalities which are regulated by the corneal-trigeminal ganglion pathway. An important contributor to ocular homeostasis is …
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Pathogenesis of Dry Eye in Graft Versus Host Disease (GVHD): Role of Ocular Mucins and Conjunctival Fibrosis
… major side effect i.e Graft vs. Host Disease (GVHD). GVHD is a complex, multi-organ disease resulting from an immunological attack by donor engrafted immune cells to host organs, including the eye surface. Mostly based on the time of disease onset after transplantation, GVHD is divided …
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ANALYSIS OF MICROBIOME IN VARIOUS HUMAN MEDICAL CONDITIONS USING NEXT-GENERATION SEQUENCING OF THE 16S rRNA GENE
… within the body. Influenced by age, gender, and disease, it mirrors broader microbial ecosystems. This study specifically delves into the ocular and gastrointestinal tract microbiome, comparing its composition in 43 healthy and diseased patients using 16S rRNA gene sequencing. We identified a …
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Structural and functional characteristics of meibomian glands in meibomian gland dysfunction
… contact lens wearers and participants with dry eye disease (DED). The third prospective study used multimodal imaging to evaluate MG orifices and explore their associations with, and ability to predict symptoms. The fourth study investigated inter-day and intersubject variations in meibum …
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Reiterative FGF signaling determines the identity and morphology of the lacrimal gland
… in the lacrimal gland is the main cause of dry eye disease, but existing treatments only alleviate the symptoms without curing the underlying disease. To develop curative measures, a thorough understanding of lacrimal gland development is needed. Lacrimal gland is formed as a result of …
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Imaging of Meibomian Glands in Various Species
… for tear stability which is disrupted during dry eye disease. Blink rate varies across species suggesting differences in tear film stability, MG anatomy, and meibum quality. Meibography is performed on humans, but little is known about MG in other species. Using ex vivo meibography we imaged …
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Characterization of Ocular Surface Pathology and Tear Film Dysfunction Due to Type 1 and Type 2 Diabetes Mellitus
… affecting heart, nerves, kidney, and eyes. While the etiological mechanisms of diabetes-associated retinopathy and cataract have been well characterized, the time kinetics and the severity of diabetes-mediated injury to the ocular surface and its various components like tear film, …
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Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx
… Diabetes mellitus is the disease of the century that affects many body organs. In the eye, diabetes mellitus causes retinopathy, cataract, glaucoma, papillopathy, and ocular surface disease. Ocular surface abnormalities in patients of diabetes mullites include impairment of …
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Development of Multifunctional Drug Delivery Systems for Locoregional Therapy
… meaningful benefits to patients with localized diseases (e.g., osteoarthritis, ocular disorders and liver cancers). However, improvements are required for this type of treatment to be more effective. For transarterial chemoembolization (TACE) therapy of hepatocellular carcinoma (HCC), the most …