Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Drusen"”.
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Blau/Gelb-Perimetrie bei Patienten mit altersabhängiger Makulopathie
… graded by two independent observers for soft drusen and presence of focal hyperpigmentation. Additional in 35 patients images with the SLO were created and morphological findings were graded digitally. Mean sensitivity and standard deviation of all patients exibited a significant reduction …
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Visual field and structural alterations in age-related macular degeneration
… programming and evaluated for repeatability. Drusen quantification of fundus photographs and retro-mode scanning laser ophthalmoscopic images was performed. Visual field progression was related to structural changes derived from both manual and automated methods. Principal Findings: • Visual …
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
… The formation of extracellular deposits, termed drusen, below the retinal pigment epithelial (RPE) cell layer in the outer retina is a pathognomonic hallmark of AMD. The composition of drusen is complex, but identified elements include iron, complement components, and amyloid protein derivatives. …
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Untersuchungen zu den genetischen Ursachen hereditärer Netzhautdegenerationen des Menschen
… zahlreicher weißlich-gelber Flecken, sogenannter Drusen, in radiärer Anordung am hinteren Augenpol ist das charakteristische Merkmal einer Gruppe von Netzhauterkrankungen mit gemeinsamer Ätiologie, die unter dem Begriffen Doynsche Honigwaben Dystrophie (DHRD), Malattia Leventinese (MLVT) oder …
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Advanced imaging biomarkers in age-related macular degeneration
… από την οπτική τομογραφία συνοχής (πχ όγκος των drusen, χρωστικές αλλαγές) και υποδεικνύουν κίνδυνο για εξέλιξη της νόσου. Επιπλέον, πιθανοί βιοδείκτες ανιχνεύονται μέσω σύγχρονων μέσων απεικόνισης, όπως οι υπερανακλαστικοί κόκκοι καθώς και πολλοί υπότυποι των drusen, οι οποίοι βρίσκονται υπό …
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Deep-learning Enabled Accurate Bruch’s Membrane Segmentation in Ultrahigh-Resolution Spectral Domain and Ultrahigh-Speed Swept Source Optical Coherence Tomography
… clinical findings with AMD and DR, such as drusen and choriocapillaris (CC) blood flow deficit, are located adjacent to the Bruch’s membrane (BrM). BrM is a very thin (2–6 µm) extracellular matrix, which is generally not resolved in commercial OCT instrument and therefore challenging to …
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Vascular changes in Alzheimer’s disease and other types of dementia in the retina of human and animal
… blood vessels, in spherical structures within drusen, choroid and sclera and an intracellular labelling was detected in the inner layers of the human retina. Where Aβ accumulations were detected extracellularly in the human retina, these were in few areas. No increase in Aβ accumulations was …
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Graph Theory and Dynamic Programming Framework for Automated Segmentation of Ophthalmic Imaging Biomarkers
… image quality and was capable of segmenting both drusen and geographic atrophy. To account for the complex manifestations of DME, a novel kernel regression-based classification framework was developed to identify retinal layers and fluid-filled regions as a guide for GTDP segmentation.</p><p>The …
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Connexin43 as a novel therapeutic target in age-related macular degeneration
… be associated with increased GFAP expression in drusen-free areas of AMD affected retina. Activated and migrating microglia were also discovered in this area. These findings indicate a close association between increased Cx43 expression with disease progression in human AMD. The combined animal …
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Retinal vessel segmentation using textons
… the problem of removing pathological anomalies (Drusen, exudates) for retinal vessel segmentation, which have been identified by other researchers as a problem and a common source of error. The results show that the modified method shows some improvement compared to a previously published method. …
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Structure-function relationships in Age-related macular degeneration in an era of multi-modal retinal imaging
… its recently reported phenotype, reticular pseudodrusen/subretinal drusenoid deposits (RPD/SDD). <br/><br/>Chapter 2, is an overview of the methods used to carry out the functional tests and imaging in the NISA study, as well as the rationale for inclusion of those assessments. In the same …
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Exploring retinal changes in Dementia and Multiple Sclerosis
Diagnosis and monitoring progression of neurodegenerative diseases relies on the assessment of clinical symptoms such as cognitive impairment in Alzheimer`s disease (AD) and disability in Multiple Sclerosis (MS). Detection of molecular and morphological hallmarks in the brain or spinal cord is …