Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"Drugs of abuse"”.
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Hair analysis for drugs of abuse
This thesis covers a range of important issues in hair analysis and includes 27 scientific works in which the name of the candidate was either listed as the first author or as the major contributor. The work presented in this thesis involved the development of a series of analytical methods to …
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Gas chromatographic studies of drugs of abuse
… a good technique for trace analysis of drugs in biological samples. 2. For many of the drugs studied the detector response curves are not linear with sample concentration but the calibration curves are reproducible if care is exercised. This makes quantitative analysis feasible down …
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Study of SERS for the detection of drugs of abuse
A study of the use of Surface Enhanced Raman Spectroscopy (SERS) for the detection of illicit drugs in oral fluid using metal enhancement mechanisms was undertaken. Initial work investigated ecstasy tablet composition using Raman to identify what drugs and excipients might be present in oral fluid …
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Modeling HIV-1 Infection and Immune Responses Under Drugs of Abuse
The frequent use of drugs of abuse among HIV infected individuals is a major concern. Drugs of abuse, such as opiates, have been widely associated with enhanc ing HIV replication, accelerating disease progression, and diminishing host-immune responses. Moreover, opiates such as morphine have also …
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Development of electrochemical devices for the determination of drugs of abuse
… con enzimas, anticuerpos o nanomateriales, para ofrecer mayor selectividad hacia el análisis del compuesto de interés. Teniendo esto en cuenta, en esta tesis doctoral se han desarrollado sensores y biosensores electroquímicos, miniaturizados y desechables, para la determinación sensible y …
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The Effect of Drugs of Abuse and HIV-1 GP120 on Autophagy in Astrocytes
The life expectancy of individuals infected with HIV-1 has significantly improved since the introduction of highly active anti-retroviral therapy (HAART). However, this has led to an increase in the prevalence of HIV-associated neurocognitive disorders (HAND), especially the mild forms of HAND. …
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Modeling the Effects of Drugs of Abuse on HIV Infections with Two Viral Species
Injection drug use is one of the greatest risk factors associated with contracting human immunodeficiency virus (HIV), and drug abusers infected with HIV suffer from a higher viral load and rapid pathogenesis. Replication of HIV may result in a large number of mutant viruses that can escape …
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LC-MS/MS determination of various drugs of abuse and metabolites in municipal wastewater effluent samples
… for the quantification and confirmation of 8 drugs of abuse (cocaine, codeine, MDMA, methadone, methamphetamine, morphine, nicotine, and oxycodone) and their various metabolites (acetylmorphine, cotinine, EDDP, amphetamine and benzoylecgonine) in municipal wastewater effluent samples. …
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Liquid Chromatography -- Tandem Mass Spectrometry Techniques for Drugs of Abuse as Applied to Bacterial and Forensic Toxicology
The ability of bacterial species to transform complex chemical substances has been well documented. Some of these species are native to the human gastrointestinal tract and play an active role in the postmortem decomposition process. These species have potential to cause biotransformations that …
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Examining the Behavioral and Molecular Aspects of Adolescent Nicotine Dependence: Implications for Vulnerability to Drugs of Abuse
… (18.1 percent) are smokers. The commencement of smoking at a young age is thought to increase addiction liability, decrease the probability of successful cessation, and correlate with a higher number of cigarettes smoked per day. Studies from the World Health Organization indicate that between …
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Impact on Endogenous Neural Stem Cells and Neurogenesis by Drugs of Abuse: From Fetal Neurodevelopment to the Adult Brain
Neural stem cells (NSCs) are a subpopulation of cells, found within the fetal and adult brain, that are integral to brain development, maintenance, and repair. Neurogenesis is the process through which NSCs proliferate and differentiate to create new neural cells within the central nervous system. …
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Forensic Analysis of Trace Evidence Fibers and Drugs of Abuse In Biological Matrices Using Chromatographic and Mass Spectrometric Methods
… fibers found at crime scenes as trace evidence often provide leads or confirmations in criminal investigations. The development of analytical techniques for forensic discrimination of fibers by micro-extractions of dyes followed by liquid chromatography (LC) or capillary electrophoresis (CE) …
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The detection of drugs of abuse in biological matrices using enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry
The aim of this study was to investigate the potential use of ELISA and LC-MS-MS in combination and as individual techniques, for the detection of drugs of abuse in biological matrices. Overall the LC-MS-MS method showed good correlation results for opiates compared to the GC-MS method. 6-MAM was …
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A post-mortem toxicological investigation: Understanding the role of drugs of abuse in violent fatalities in Cape Town, South Africa
… burdens worldwide, accounting for the death of millions of individuals annually. The literature reports an association between drug use and violence, providing data indicating that the use of psychoactive substances increases the risk of morbidity and mortality due to violent acts. South …
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The Differential Contribution of Striatonigral and Striatopallidal Neurons in Mediating Responses to Therapeutic Agents and Drugs of Abuse: A Dual Role for DARPP-32
<p>The basal ganglia are a set of subcortical structures which integrate information from diverse brain areas to coordinate vital behaviors including movement, reward, and motivational processes. The striatum is the main input center of the basal ganglia which sends projections to the output nuclei …
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Substance use in adolescents and young adults: Interactions of drugs of abuse and the role of parents and peers in early onset of substance use
Background: Misuse of substances is a major contributor to disability and mortality worldwide. The use of tobacco, alcohol, and illegal drugs in adolescence and young adulthood are well-known risk factors for subsequent substance-related harms. A better understanding of adolescent and young adult …
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Applications of Disposable Pipette Extraction for Analysis of Drugs of Abuse Vitamin D Metabolism Testosterone and Inborn Errors of Metabolism by Gas and Liquid Chromatography/mass Spectrometry
… and polarity, two major ion exchange phases of weak cation and anion were experimented. For weak anion exchange, oxalic acid was found to irreversibly bind to the sorbent and small polar acid, uracil and thymine cannot be effectively extracted. For weak cation exchange, four extraction …
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Diverse Kappa Opioid Receptor Agonists: Relationships Between Signaling and Behavior
<p>The opioid system, comprised mainly of the three opioid receptors (kappa, mu and delta) and their endogenous neuropeptide ligands (dynorphin, endorphin and enkephalin, respectively), mediates mood and reward. Activation of the mu opioid receptor is associated with positive reward and euphoria, …
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