Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Drug-polymer interactions"”.
-
Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
… nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce acetonide (FA) and triamcinolone (T1) were encapsulated with a combination of nonionic surfactant hydrogenated castor oil (HCO) and …
-
Investigation of Pharmaceutical Mass Transfer Phenomena Using Molecular Dynamics Simulations
… study included (1) the understanding of drug crystal dissolution at molecular level, (2) the elucidation of an unique mechanism for facile polymorphic transformation of crystalline drugs in solutions, and (3) the determination of drug-polymer interactions at water-crystal interface and …
-
Antimicrobial wafers as a novel technology for infection control in chronic wounds.
… bioburden and improve healing. Lyophilised, biopolymeric antimicrobial wafers can offer a contemporary, user-friendly, self-adhesive and effective approach for the management of suppuration and polybacterial contamination in a wide range of non-healing wounds. Cohesive, non-friable, porous, disc …
-
Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
… of this study is to develop a clear, aqueous drug-loaded nanomicellar formulation utilizing FDA approved polymers, namely Hydrogenated castor oil 40 (HCO-40) and Octoxynol 40(OC-40) as a potential-therapeutics for AMD. Hydrophobic drugs such as curcumin (CUR), celecoxib (CXB), and resveratrol …
-
Novel nanocarriers to improve drug delivery for age-related macular degeneration
… of this study was to develop aqueous, clear and drug-loaded nanomicellar formulations using FDA-approved polymers namely Hydrogenated castor oil 40 (HCO-40), Octoxynol-40 (OC-40) and Vitamin E TPGS as potential delivery cargos to treat AMD. Lipophilic drugs such as etodolac (ETD), oxaprozin (OXP) …
-
Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions
… miscibility and molecular interaction in drug-polymer systems of poorly soluble drugs and correlate it with the performance of prepared or reported SDs (solid dispersions). Crystallization tendencies of five different drugs [i.e. Curcumin (CUR), indomethacin (IND), flutaminde (FLU), …
-
Investigating the Variations in Molecular Mobility within Amorphous Formulations using Terahertz Spectroscopy
Numerous promising drug candidates are discontinued during development due to their poor aqueous solubility, a common challenge encountered by crystalline drugs. This challenge can be overcome by formulating such drugs into amorphous solid dispersions (ASDs). ASDs can load higher doses of drugs, …
-
Temperature-dependent Terahertz Time-domain Spectroscopy as a Tool to Assess the Crystallisation Tendencies of Amorphous Drug-Polymer Systems
… and bioavailability of poorly water-soluble drugs. However, their inherent thermodynamic instability poses a major formulation challenge due to the tendency of amorphous drugs to recrystallise over time. This thesis explores the use of temperature-dependent terahertz time-domain spectroscopy …
-
Characterisation of drug loaded insoluble polymeric matrices prepared by hot melt extrusion technology for drug delivery applications.
… characterise the physiochemical, rheological and drug release properties of drug loaded insoluble matrices prepared by HME technology, to provide a deeper understanding of the mechanisms which affect drug release from hot melt extruded solid dosage forms. Polymethacrylate polymers are frequently …
-
ACID-BASE REACTIONS IN DIFFERENT SOLID-STATE FORMS
Most drug substances are reported to be either weak acids or weak bases. Hence, acid-base reactions are commonly observed in pharmaceutical systems with samples including salts, amorphous solid dispersions, and in formulated products. Salt formation of active pharmaceutical ingredients (APIs) is …
-
Development of hot-melt extrusion as a novel technique for the formulation of oral solid dosage forms
… to investigate the efficiency of hydrophilic polymers to enhance the dissolution rate of poorly water-soluble APIs processed by HME. Indomethacin (INM) and famotidine (FMT) were selected as model active substances while polyvinyl caprolactam graft copolymer, Soluplus® (SOL) and …
-
Physicochemical characterization of solid dispersions prepared using hot-melt extrusion technology
… manufacture solid dispersions of poorly soluble drugs, bicalutamide (BL) and celecoxib (CX), and to characterize the physicochemical properties of the prepared melt extrudates by different analytical techniques. Hot melt extruded solid dispersions of BL were prepared using polyethylene oxide …