Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Drug-polymer"”.
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Solubility Enhancement via Melt Extrusion: Drug-polymer Solubility, Physicochemical Characterization and Quality by Design
Many new drugs developed face oral delivery challenges and absorption due to poor biopharmaceutical properties. Formation of solid dispersions is a very widely applied technique for solubility enhancement of water insoluble drugs. In order to form stable solid dispersions it is important to select …
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Drug-Polymer and Drug-Lipid Miscibility for the Development of Amorphous Solid Dispersions and Solid Lipid Nanoparticles
… to overcome limited solubility. Investigation of drug-polymer and drug-lipid miscibility was carried out to enhance drug performance by assessing solubility and particle size. Miscibility was then correlated to performance to determine successful preparation of FLT SDs and SLNs.|Four polymers used …
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Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions
… miscibility and molecular interaction in drug-polymer systems of poorly soluble drugs and correlate it with the performance of prepared or reported SDs (solid dispersions). Crystallization tendencies of five different drugs [i.e. Curcumin (CUR), indomethacin (IND), flutaminde (FLU), …
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Temperature-dependent Terahertz Time-domain Spectroscopy as a Tool to Assess the Crystallisation Tendencies of Amorphous Drug-Polymer Systems
… and bioavailability of poorly water-soluble drugs. However, their inherent thermodynamic instability poses a major formulation challenge due to the tendency of amorphous drugs to recrystallise over time. This thesis explores the use of temperature-dependent terahertz time-domain spectroscopy …
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Exploration of a doxorubicin-polymer conjugate in lipid-polymer hybrid nanoparticle drug delivery
Nanoparticle (NP) drug delivery is a major focus in the research community because of its potential to use existing drugs in safer and more effective ways. Chemotherapy encapsulation in NPs shields the drug from the rest of the body while it is within the NP, with less systemic exposure leading to …
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Investigation of Pharmaceutical Mass Transfer Phenomena Using Molecular Dynamics Simulations
… study included (1) the understanding of drug crystal dissolution at molecular level, (2) the elucidation of an unique mechanism for facile polymorphic transformation of crystalline drugs in solutions, and (3) the determination of drug-polymer interactions at water-crystal interface and …
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Development of Methods to Predict and Enhance the Physical Stability of Hot Melt Extruded Solid Dispersions
… and in-vivo performance of poorly water-soluble drugs. However, because of their meta-stable nature, the physical stability of amorphous solid dispersions has been considered to be the main obstacle for their formulation development and commercialisation by the pharmaceutical industry. The aim of …
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Investigating the Variations in Molecular Mobility within Amorphous Formulations using Terahertz Spectroscopy
Numerous promising drug candidates are discontinued during development due to their poor aqueous solubility, a common challenge encountered by crystalline drugs. This challenge can be overcome by formulating such drugs into amorphous solid dispersions (ASDs). ASDs can load higher doses of drugs, …
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Characterization of different hydrophilic polymers and their applicability in hot melt extrusion technology
… field involves investigation of a new drug, delivery route, a delivery system, a technology to design the delivery system, or a combination thereof. Scientists have explored several delivery routes such as oral, pulmonary, nasal, injection/implant, transdermal/dermal, transmucosal etc. …
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Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
… nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce acetonide (FA) and triamcinolone (T1) were encapsulated with a combination of nonionic surfactant hydrogenated castor oil (HCO) and …
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Development of hot-melt extrusion as a novel technique for the formulation of oral solid dosage forms
… to investigate the efficiency of hydrophilic polymers to enhance the dissolution rate of poorly water-soluble APIs processed by HME. Indomethacin (INM) and famotidine (FMT) were selected as model active substances while polyvinyl caprolactam graft copolymer, Soluplus® (SOL) and …
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Nuclear Magnetic Resonance for the Characterisation of Hot-Melt Extruded Pharmaceutical Amorphous Solid Dispersions
… suffer from poor solubility. The formulation of drug/polymer amorphous solid dispersions (ASDs) is one of the most successful strategies for improving the oral bioavailability of poorly soluble APIs. Hot-melt extrusion (HME) is one method for preparing ASDs that is growing in importance in the …
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Supercritical fluid spray processes for microencapsulation and formation of submicron aqueous dispersions of pharmaceutical compounds
… technique where an organic solution of drug + polymer in solvent is atomized (sprayed) into supercritical (SC) CO₂. Upon liquid mixing, the solute materials precipitate to form microparticles. A Vapor-over-Liquid technique has been used to produce larger, uniform particle sizes of …
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Impact of end groups of PLGA on polymer properties and ocular implant performance
… dosage forms. Conventionally, most ophthalmic drugs are delivered topically in the form of eye drops. However, the short pre-corneal residence time requires frequent instillation which results in fluctuations in therapeutic concentration, and low patient compliance coupled with high health care …
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Antimicrobial wafers as a novel technology for infection control in chronic wounds.
… bioburden and improve healing. Lyophilised, biopolymeric antimicrobial wafers can offer a contemporary, user-friendly, self-adhesive and effective approach for the management of suppuration and polybacterial contamination in a wide range of non-healing wounds. Cohesive, non-friable, porous, disc …
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Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
… of this study is to develop a clear, aqueous drug-loaded nanomicellar formulation utilizing FDA approved polymers, namely Hydrogenated castor oil 40 (HCO-40) and Octoxynol 40(OC-40) as a potential-therapeutics for AMD. Hydrophobic drugs such as curcumin (CUR), celecoxib (CXB), and resveratrol …
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Characterisation of drug loaded insoluble polymeric matrices prepared by hot melt extrusion technology for drug delivery applications.
… characterise the physiochemical, rheological and drug release properties of drug loaded insoluble matrices prepared by HME technology, to provide a deeper understanding of the mechanisms which affect drug release from hot melt extruded solid dosage forms. Polymethacrylate polymers are frequently …
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Novel nanocarriers to improve drug delivery for age-related macular degeneration
… of this study was to develop aqueous, clear and drug-loaded nanomicellar formulations using FDA-approved polymers namely Hydrogenated castor oil 40 (HCO-40), Octoxynol-40 (OC-40) and Vitamin E TPGS as potential delivery cargos to treat AMD. Lipophilic drugs such as etodolac (ETD), oxaprozin (OXP) …
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The development of PVP-based solid dispersions using hot melt extrusion for the preparation of immediate release formulations
… and clinical effectiveness of a poorly soluble drug can be highly affected by its formulation design. In this respect, research on solid dispersion of hydrophilic carrier has commenced a decade ago to resolve the problem of poorly soluble drug. However, the availability of solid dispersion is …
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Synthesis and Applications of Cellulose Derivatives for Drug Delivery
… to produce new derivatives of cellulose for drug delivery applications, methods were developed to regioselectively modify C-6 halo cellulose esters to produce cationic derivatives via nucleophilic substitution. Reaction of C-6 substituted bromo and iodo cellulose with trialkylated amines and …
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