Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 162 for “"Drug-induced"”.
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Computational approaches to predicting drug induced toxicity
Novel approaches and models for predicting drug induced toxicity in silico are presented. Typically, these were based on Quantitative Structure-Activity Relationships (QSAR). The following endpoints were modelled: mutagenicity, carcinogenicity, inhibition of the hERG ion channel and the associated …
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Classifying drug-induced epileptic seizures in zebrafish larvae
… classifying zebrafish larvae having an (PTZ induced) epileptic seizure. The model also computes biomedical parameters describing behavioural attributes of the larvae. Several data mining approaches were implemented for the data, of which best results were obtained for support vector machine …
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Genomics study of anti-tuberculosis drug-induced hypersensitivity reactions
Introduction: All first-line anti-tuberculosis drugs can be associated with all phenotypes of cutaneous adverse drug reactions (CADR). Second-line drugs are associated with much poorer outcomes. Thus, identifying the offending drug in poly-pharmacy is difficult. Re -challenge with the drug is the …
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The natural history of Efavirenz Drug Induced liver injury
… natural history of the previously reported EFV drug induced liver injury (DILI), is unknown. Objectives To establish causality assessment for the drug-induced liver injury and elucidate the natural history of EFV DILI by observing a cohort of patients through documenting all the factors …
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Drug induced tolerance mechanisms of the fungal pathogen Candida albicans
… of resistance. Here we describe mechanisms of drug tolerance.<p></p>
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A Comparison of ECS and Drug Induced State-Dependent Learning
The purpose of the present experiment is twofold: (a) to determine if FS and ECS or just ECS can be used as an agent to produce "dissociated" learning in a multi-trial procedure, and (b) if shown, to determine the effectiveness of these agents relative to three different dosages of sodium …
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The role of potential antioxidant in medicinal drug-induced oxidative stress
<p>"Most medicinal drugs have adverse effects. Among the most commonly used of these drugs are several types, known as "oxidative drugs". These are believed to cause adverse effects that induce oxidative stress, an imbalance of generation and detoxification of reactive oxygen species. So it is a …
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The Role of Vitamin D and Antipsychotic Drug-induced Weight Gain
… in the form of second generation antipsychotic drugs (SGAs), including quetiapine, is the primary treatment for schizophrenia; however, the growth in utilization of these medications has led to a simultaneous rise in the occurrence of weight gain and metabolic syndrome in this patient …
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Cocaine conditioned place preference : expression, endurance, extinction, and drug-induced reinstatement
… maintenance, and extinction of a cocaine-induced conditioned place preference was studied using a three-chamber 'unbiased' apparatus. During training, rats were given four 20 minute pairings of one chamber with cocaine (Experiment 1, 3 and 4: 10 mg/kg, IP; Experiment 2: 5, 10, and 20 …
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Human Liver Organoids as models for investigating drug-induced liver injury
The liver is the primary organ involved in drug detoxification, hence being highly exposed to the risk of drug induced liver injury (DILI). DILI is the main cause for acute liver failure in western countries and post-marketing withdrawal of drugs. This is highly due to the poor identification of …
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The distribution and localization of drug-induced secondary constrictions in human chromosomes
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Integrated imaging and circulating biomarkers for the assessment of drug-induced hepatotoxicity
Drug-induced liver injury (DILI) is a major burden for health care systems and a principal reason for attrition during drug development. Prediction of clinical DILI remains difficult and diagnosis is usually based on exclusion using blood-based biomarkers for cell injury. Currently used chemistry …
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N-Acetylcysteine for non-paracetamol drug-induced liver injury: A systemic review
Aims: There are limited therapeutic options for drug-induced liver injury (DILI). N-acetylcysteine (NAC ) is known to be of benefit in management of DILI due to paracetamol overdose and may also be useful in the management of non-paracetamol DILI. Our objective was to systematically review evidence …
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Development of circulating microRNA in drug-induced liver injury: studies in humans and zebrafish
… used as biomarkers in patients with paracetamol-induced liver injury. Whether the miRNAs discovered in humans could be back-translated to zebrafish with the aim of developing a liver toxicity model to replace rodent use was also investigated. First, the miRNA signature of DILI induced by …
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Development and validation of an in vitro human model of drug-induced vascular injury
Drug safety is a major cause of attrition in contemporary drug development. Many promising candidate drugs are terminated in the developmental process or withdrawn in the post-approval stage because of adverse drug reactions (ADRs). Among these, cardiovascular (CV) ADRs occur with a high incidence. …
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
5-Fluorouracil(5-FU)is a cytotoxic drug that is widely used for the treatment of colon cancer. However, 5-FU-resistance is still a common issue which needs to be overcome. Understanding the molecular pathway of 5-FU-induced apoptosis will help designing more effective cancer treatments. …
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Influence of genotoxic drug-induced post-translational modifications on mutant p53 stability and oncogenic activities
… studies have demonstrated that DNA-damaging drugs currently used in the clinic aimed at activating wild type p53, can also stabilise and activate mutant p53 oncogenic functions and thereby paradoxically enhance tumour progression, resulting in poor response to the treatment. In this study we …
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