Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Drug-gene interactions"”.
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Clinical Drug-Gene and Drug-Drug-Gene Interactions for the Most Commonly Used Chronic Drugs in the UK
… to uncover novel and clinically important drug-gene interactions (DGIs) and drug-drug-gene interactions (DDGIs) among 50 commonly used chronic drugs and 50 commonly used chronic drug combinations in the UK.<b><br/></b><b><br/></b><b>Methods</b>: Using the UK Biobank (cross-sectional) cohort …
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Conception and Implementation of a Pharmacogenomic Plausibility Check: Integrating Molecular Data to Optimize Established Drug Therapy Safety Workflows
… availability of freely accessible information on drug-gene interactions enables the use of such data for a plausibility check during the prescribing process, thereby enhancing the safety of drug therapy. By conducting a pre-emptive test of the genotype of relevant enzymes, the result can be …
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Identification of Novel Regulatory Genes in Acetaminophen Induced Hepatocyte Toxicity by a Genome-Wide CRISPR/Cas9 Screen
… options result in a high rate of liver failure, generally resulting in either organ transplant or mortality. The underlying molecular mechanisms of injury are not well understood and effective therapy is limited. Identification of previously unknown genetic risk factors would provide new …