Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Drug-eluting"”.
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DRUG ELUTING TISSUE ENGINEERED VASCULAR GRAFTS
… been significantly reduced through the use of Drug eluting stents (DES), which contain antiproliferative agents that suppress the inflammatory process after implantation reducing the incidence of IH. This study evaluates the efficacy of using and synthesizing Drug Eluting Tissue Engineered …
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Drug eluting hydrogels design, synthesis and evaluation
… have successfully proved themselves useful for drug delivery applications and several delivery routes have been developed over the years. The particular interest in this work was to design, synthesise and evaluate in situ forming drug eluting hydrogels, which have the potential to ameliorate the …
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Drug eluting electrospun scaffolds for tissue regeneration
The desired healing response to electrospun scaffolds in tissue engineering is often limited by poor ingrowth due to insufficient porosity, thrombogenicity, lack of vascularisation and/or excessive inflammation. This study aimed at increasing structural porosity and incorporating/delivering …
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Remote controlled drug release in drug-eluting stents
… the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This …
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Drug eluting prosthetic joints through drug cluster morphology control
… involving arthrodesis and amputation. Most drug eluting polymers that were in development to address this problem failed due to toxic degradation products, insufficient drug release, and insufficient mechanical strength. The gold standard of treatment uses antibiotic eluting bone cement …
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Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating
Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant lumen loss due to growth of vascular tissue). Biodurable (non-erodible) …
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Comparing long-term antiplatelet strategies to prevent morbidity and mortality in patients with drug-eluting coronary stents
… unknown in patients greater than one year after drug-eluting stent (DES) placement. Methods: We modeled life expectancy (LE) using published data by building a Markov model to compare several APT strategies composed of aspirin and clopidogrel, both as monotherapy and in various clinically …
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Eine Stentimplantation außerhalb der FDA-Indikationen für DES ist unabhängig von der Wahl des Stenttyps mit einer erhöhten Stentthromboserate verbunden
… restenosis, which led to the invention of drug-eluting-stents. Unfortunately, the incidence of stent thrombosis rose with the use of drug-eluting stents. Knowing that many of the drug-eluting stents were used in lesions that were considered off-label, e.g. complex lesions, the rise of …
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A system for impedance characterization of coronary stents
… patients suffering from coronary heart disease. Drug-eluting stents are now the preferred choice of stent but their performance is still limited by delayed healing of the important endothelial cell layer that lines the artery wall (Capodanno et al, 2011). It is very important that the endothelial …
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Computational model of local intravascular drug delivery
Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical to examine factors that alter local biologic outcome. The central hypothesis of …
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Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery
Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what drives the safety and efficacy of these devices. The goal of this thesis was …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
… still occurs in coronary arteries implanted with drug-eluting stents, with the maximum thickness observed at the vascular site of maximum inter-strut angle. This phenomenon may be related to the specific spatiotemporal drug uptake in the arterial wall. In this work local delivery of a hydrophobic …
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Novel strategies for optimising drug release from medicinal implants
… a neointima, which renarrows the artery lumen. Drug-eluting stents (DES) release drugs to inhibit SMC proliferation and have been very successful in reducing ISR rates. However, they are not suitable for every patient group and lesion type, and may induce delayed healing of the endothelium, …
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Hochfrequenzrotablation zur Behandlung von Restenosen in Koronarstents
… intra-coronary brachytherapy and the usage of drug-eluting stents show a promising reduction of these iatrogen lesions recently. Methods: RA with adjunct angioplasty was used in 40 patients (age 58±11) with diffuse ISR six month after initial stent implementation. Both a quantitative coronary …
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Therapeutic contact lenses for extended drug delivery
There is significant interest in hydrogel-based drug-eluting contact lenses as platforms for topical ocular drug delivery. These devices have shown to provide an increased residence time of drugs at the surface of the eye, leading to enhanced bioavailability (~ 50%) when compared to eye drops …
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The study of a drug coating applied using a cold atmospheric plasma: everolimus coating properties
… Everolimus is an anti-proliferative drug commonly used in drug-eluting stents. The coatings were characterised using a variety of analytical techniques, including water contact angle (WCA) analysis, Fourier-transform infrared (FTIR) spectroscopy, Raman spectroscopy, deep ultraviolet …
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Hemocompatible polymer thin films fabricated by Electrostatic Self-Assembly (ESA)
… of stent is restenosis. Current development of drug-eluting stents shows successfully reduce the occurrence of restenosis. Other than using drugs, electrostatic self assembled (ESAd) thin films may be the potential candidates to prevent restenosis. ESA is a process to fabricate thin films bases …
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Biorubber (PGS) : evaluation of a novel biodegradable elastomer
… U.S. for 2004. Another promising field involves drug delivery, particularly in combination devices like drug-eluting stents. The potential non-medical applications are biodegradable rubbish bags, the absorbent material used in sanitary napkins or diapers, and even fishing lure or chewing gum.
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