Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"Drug-drug interactions"”.
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Drug-drug interactions between antiretrovirals and bedaquiline
… for multiple reasons, including potential drug-interactions. Drug-resistant TB is difficult to treat and is associated with high treatment failure rates, mainly because the antimycobacterial drugs currently available are ineffective against drug-resistant TB. Bedaquiline is a new …
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Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
Drug transporters play an important role in drug disposition and can be major determinants of drug pharmacokinetics, pharmacodynamics and toxicity. In contrast to drug metabolizing enzymes, which mainly concentrate in the liver and small intestine, drug transporters are expressed ubiquitously …
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FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS
… and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs (buspirone, caffeine, dextromethorphan and losartan) used to probe cytochrome P450 (CYP) activities, a significant decrease in …
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Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
… membrane transporters which play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of functionality and molecular expression of drug transporters can prove to be of utmost importance in drug delivery or drug design by targeting specific transporter proteins. …
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Nonlinear mixed-effects modelling of drug-drug interactions between antiretroviral therapy and tuberculosis treatment
… treatment of HIV and TB often results in drug-drug interactions (DDIs), mediated especially by rifampicin, a key component of the TB regimen and potent enzyme and transporter inducer. These DDIs may compromise treatment safety and efficacy, potentially leading to therapeutic failure and …
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Quantitative Structure-Activity Relationship Modeling to Predict Drug-Drug Interactions Between Acetaminophen and Ingredients in Energy Drinks
The evaluation of drug-drug interactions (DDI) is a crucial step in pharmaceutical drug discovery and design. Unfortunately, if adverse effects are to occur between the co-administration of two or more drugs, they are often difficult to test for. Traditional methods rely on in vitro studies as a …
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Pharmacometrics of dolutegravir and tenofovir: a quantitative approach to characterise drug-drug interactions, pharmacogenetics and optimise treatment
… often challenging because of the potential for drug-drug interactions. Dolutegravir-based regimens are now the preferred first-line option for the management of HIV. Therefore, many African countries have transitioned most PLWH from efavirenz- to dolutegravir-based regimens. A fixed-dose …
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Pharmacometric modelling to inform and improve TB and HIV treatment: Focus on drug-drug interactions and neglected populations
… those with co-morbidities requiring additional drug treatments, and those with drug-resistant strains. This leaves many unanswered questions surrounding the management of TB, HIV, and TB/HIV in these vulnerable subpopulations. In this thesis, we utilise population pharmacokinetics and …
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Introducing clinical pharmacology to hepatitis C therapy. Lessons learned from studies on therapeutic drug monitoring and drug-drug interactions
Contains fulltext : 142579.pdf (Publisher’s version ) (Open Access)
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Improvement of Gastroparesis Management By Addressing Challenges in Drug Metabolism: Studies with Metabolite Identification, Reaction Phenotyping and In Vitro Drug-Drug Interactions
… will ensure safe and effective use of these drugs and hence enhance the clinical outcome. The thesis starts with an introductory chapter which comprises a comprehensive literature review on gastroparesis and the available pharmacological treatment options. The chapter also emphasizes the …
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Population pharmacokinetic models describing drug-drug interactions and variability in HIV infected South Africans on protease inhibitor-based antiretroviral regimens with and without tuberculosis
… reduced adherence leads to the development of drug resistance. The projects in this thesis were designed to characterize the population pharmacokinetic parameters of lopinavir and ritonavir in HIV infected South Africans, to account for the drug-drug interactions between lopinavir, ritonavir …
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The pharmacokinetics of lopinavir in HIV-infected adults receiving rifampicin with adjusted doses of lopinavir
… treatment, exposing patients to multiple drug-drug interactions. As ART programs mature, more patients will be changed from first-line to second-line ART. In South Africa, the adult second-line ART consists of the protease inhibitor (PI) lopinavir/ritonavir (LPV/r) and 2 nucleoside reverse …
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Study of Potential Drug Interactions of Epidermal Growth Factor Receptor Inhibitors (EGFR inhibitors) in the Treatment of Non-Small-Cell Lung Cancer // Проучване на потенциални лекарствени взаимодействия при използване на инхибитори на рецептора на епидермалния растежен фактор (EGFR-инхибитори) при лечение на недребноклетъчен белодробен карцином
… the identification and assessment of potential drug-drug interactions in clinical practice is important. The introduction of targeted therapy has led to new challenges. These drugs have been recently introduced into clinical practice and are not well-known to specialists in terms of their …
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The significance of OATP and CYP450 in statin-flavonoid interactions
Statins are the most prescribed drug world-wide as a first-line defence to hypercholesteraemia. In rare cases, statins can have adverse events such as myotoxicity which can further progress to a potentially fatal condition, rhabdomyolysis. This risk is exacerbated by drug-drug interactions between …
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Translational high-dimesional drug interaction discovery and validation using health record databases and pharmacokinetics models
Polypharmacy leads to increased risk of drug-drug interactions (DDI’s). In this dissertation, we create a database for quantifying fraction of metabolism (fm) of CYP450 isozymes for FDA approved drugs. A reproducible data collection protocol was developed to extract key information from publicly …
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Studying the Specificity of hPXR Antagonists Using a Panel of Cell-based Assays
… Induction of CYPs contributes to adverse drug-drug interactions. Non-toxic, PXR-specific antagonists will be valuable in attenuating the adverse drug-drug interaction which is the cause of many treatment failures in clinic. However, few hPXR antagonists were reported particularly the …
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Antimycobacterial 2-aminoquinazolinones and benzoxazole-based oximes: synthesis, biological evaluation, physicochemical profiling and supramolecular derivatization
… such as lengthy and complex treatment regimens, drug-drug interactions, drug toxicities, as well as emergence of widespread multi-drug resistance. Therefore, there is an urgent and compelling need to develop new, more effective, safer drugs with novel mechanisms of action, and which are capable …
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Prediction of CYP3A4 metabolic activity from whole genome RNA-seq data with feature selection machine learning methods
… P450 (CYPs), contributes significantly to drug clearance and drug-drug interactions. The goals of this project are to identify hepatically-expressed genes that are associated with CYP3A4 metabolic activity in human liver tissue and to predict CYP3A4 activity using gene expression data from …
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Using human metabolic enzyme profiling as an innovative technology in the drug development process
… properties, such as poor bioavailability and drug-drug interactions, have been one of major reasons for the failure of new pharmaceuticals in clinical trials. These dropout risks can be reduced by early knowledge of human pharmacokinetics in the drug discovery process. Although new drug …
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