Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 196 for “"Drug-delivery system"”.
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Towards an improved ocular drug delivery system
… which will improve the efficiency of ocular drug delivery systems. Initially, it was necessary to review the information available on the nature of the tear fluid and its relationship with the eye. An extensive survey of the relevant literature was made. There is a common belief in the …
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Magnetic targeted drug delivery system in gene therapy
Drug delivery system is a method to transport the drug of the required amount accurately to the targeted diseased part. Recently, the concept of Magnetic Targeted Drug Delivery System (MTDDS), based upon magnetic particles under the action of an external magnetic field, exhibits considerable …
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Sporopollenin exines as a novel drug delivery system
… are fast becoming the most successful delivery systems for the oral delivery of drugs and food additives. Since many drugs are proteins and are destroyed in acidic conditions, microcapsules offer protection against the harsh environment of the gastrointestinal (GI) tract. Although the …
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Design of novel drug delivery system and optimal dosage regimens
Three representative drug delivery systems were analyzed to emphasize the roles of mathematical models and computer-aided simulations in pharmaceutical research. In the first project, a protocol was developed so that the optimal regimen, consisting of the intravenous boluses and subsequent infusion …
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Intelligent Nano/Microgels for Cell Scaffold and Drug Delivery System
… on two areas: the cell scaffold and the drug delivery system. </p> <p>As for the cell scaffold, it can be realized by colloidal supra-structure microgels, which constructed by the thermo-driven gelation of the colloidal dispersion of poly(N-isopropylacrylamide-co-acrylamide) …
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Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System
<p>Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System by Jonathan A. Moreno Peptides</p> <p>[RW]<sub>4</sub> and [R<sub>5</sub>W<sub>4</sub>] have been previously identified as molecular transporter Cell Penetrating Peptide (CPP) and antimicrobial agents, respectively. These …
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The Use of Gelatin in a Multiple Drug Delivery System
… factors released either singly or in a dual system from gelatin successfully produced bone in vivo. However, single release systems require higher dosages to achieve similar healing results as observed in the dual release systems. No difference was observed between the dual release systems …
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Development & testing of ultrasound enhanced prodrug microbubble drug delivery system
Microbubble drug delivery systems vary widely in their design and. This work focused on the application of a novel microbubble system with ultrasound-mediated delivery enhancement via consumer equipment. The work involved the creation of a novel microbubble formulation using a prodrug of Bexarotene …
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A Lorentz-force actuated controllable needle-free drug delivery system
… Using this device, precise control over delivery parameters can be achieved. In addition, several portable power systems for this injector were developed, allowing the energy-intensive needle-free injector to be used in the field. The injector design was tested for repeatability and use …
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Developing a Drug Delivery System for Treatment of Vocal Fold Scarring
… of in vitro unscarred and scarred culture systems in which to eventually test our newly developed delivery systems. Initial work with these systems focused on characterizing them in order to better understand the role RGD integrin binding site concentration and cell phenotype had on …
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Thermal spray of a drug delivery system onto femoral orthopaedic implant
… (infections) behaviour. It is thought that local drug delivery would be useful to prevent implant failures that could be treated with therapeutic agents (drug/growth factor). It is hypothesised in this work that polymers proven in drug delivery for other applications could be successfully applied …
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Development of a Novel Drug Delivery System Based on Conducting Polymers
Controlled release systems offer advantages over conventional therapies by maintaining drug concentrations at therapeutically desired levels whilst simultaneously improving compliance. Intrinsically Conducting Polymers (ICP) are organic materials that have electrical, magnetic and optical …
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The development and evaluation of a hydrogel drug delivery system for dithranol.
… to investigate the possibility of developing a drug delivery system that would confine dithranol to the psoriatic plaque, whilst also providing appropriate stability and drug delivery rates. Analytical methods were developed and evaluated, to ensure that dithranol stability could be monitored …
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Photosensitizer Loaded Contact Lenses As An Externally Stimulated Ophthalmic Drug Delivery System
Ophthalmic administration of drugs is primarily associated with the treatment of ocular diseases. 90% of the ophthalmic dosage forms are given topically. However, following the topical route, only 5% ocular bioavailability is achieved. The aim of my work is to address the problems associated with …
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Amphiphilic Cell-Penetrating Hybrid Cyclic-Linear Peptides as a Drug Delivery System
… (F′-GpYEEI), and fluorescent labeled anti-HIV drugs (F′-FTC and F′-d4T). The results indicated that the presence of positively charged arginine residues on the ring and hydrophobic tryptophan residues in a sequential linear outside the ring was an optimal approach to improve the intracellular …
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Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections
Various types of rifampicin (RIF)-loaded microparticles were compared for their stability during nebulization. Poly(lactide-co-glycolide) (PLGA), chitosan (CHT) and PLGA/CHT microparticles (MPs) were prepared by emulsion, precipitation or spray-drying techniques. MPs ability to be nebulized (NE%) …
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Gastric-resident drug delivery system for prolonged gram-level dosing of Tuberculosis treatment
… 50-70% of patients fail to correctly follow the drug regimen prescribed by their health care providers. Gastric resident systems have the potential to improve medication non-adherence as they enable more infrequent dosing, a key recognized determinant of improved adherence. A number of diseases …
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