Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Drug-Induced Vascular Injury"”.
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Development and validation of an in vitro human model of drug-induced vascular injury
Drug safety is a major cause of attrition in contemporary drug development. Many promising candidate drugs are terminated in the developmental process or withdrawn in the post-approval stage because of adverse drug reactions (ADRs). Among these, cardiovascular (CV) ADRs occur with a high incidence. …
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Using transcriptomic data to detect, understand, and treat injury in the context of drug toxicity and fibrotic disease
In drug discovery, it is crucial to understand how drugs relate to complex phenotypes. This includes understanding how a drug can help to treat a condition, but also how it can result in adverse effects so that safety risks can be mitigated earlier. How effects propagate from the molecular to the …