Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Drug toxicity"”.
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DRUG TOXICITY STUDIES BASED ON VIRE2-GFP MOBILITY INSIDE PLANT CELLS
Testing the toxicity of a drug candidate is an essential process for drug development. Any failure to detect severe toxicity or side effect timely would certainly lead to health concerns and economic loss. From the period between 1953 and 2014, a total of four hundred and sixty-one drugs were …
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An Ex Vivo Model For The Assessment Of Drug Toxicity On The Human Retina
Abstract Purpose: Retinal toxicity is a common cause of drug development attrition. The aims of this research were therefore to develop the ex vivo human retina as a suitable model for the assessment of retinotoxicity, and to explore the methods in which this may be investigated. Methods: Post …
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Data Mining for Signal Detection of Targeted Therapy Related Drug Toxicity in Breast Cancer Patients
… using claims data can improve post-marketing drug surveillance. The aim of this study is to compare two routinely used approaches, the proportional reporting ratio (PRR) and Gamma Poisson Shrinker (GPS) with a tree-based scan statistic (TBSS). Using data from the Texas Cancer Registry and …
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Data Mining for Signal Detection of Targeted Therapy Related Drug Toxicity in Breast Cancer Patients
… using claims data can improve post-marketing drug surveillance. The aim of this study is to compare two routinely used approaches, the proportional reporting ratio (PRR) and Gamma Poisson Shrinker (GPS) with a tree-based scan statistic (TBSS). Using data from the Texas Cancer Registry and …
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Using transcriptomic data to detect, understand, and treat injury in the context of drug toxicity and fibrotic disease
In drug discovery, it is crucial to understand how drugs relate to complex phenotypes. This includes understanding how a drug can help to treat a condition, but also how it can result in adverse effects so that safety risks can be mitigated earlier. How effects propagate from the molecular to the …
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A Knowledge Based Approach of Toxicity Prediction for Drug Formulation. Modelling Drug Vehicle Relationships Using Soft Computing Techniques
… thesis is concerned with the prediction of drug formulations for the reduction of drug toxicity. Both scientific and computational approaches are utilised to make original contributions to the field of predictive toxicology. The first part of this thesis provides a detailed scientific …
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A Knowledge Based Approach of Toxicity Prediction for Drug Formulation. Modelling Drug Vehicle Relationships Using Soft Computing Techniques
… thesis is concerned with the prediction of drug formulations for the reduction of drug toxicity. Both scientific and computational approaches are utilised to make original contributions to the field of predictive toxicology. The first part of this thesis provides a detailed scientific …
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Engineering Liver and Cardiac Models for Drug Development and Regenerative Medicine
… data for preclinical evaluations of drug-induced liver injury and cardiotoxicity, speeding up the notoriously lengthy and inefficient drug development pipeline, as well as fundamental investigations into stem cell behavior and cell-cell interactions. Tissue engineering is also …
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Pharmacological aspects of the inhibition of mammalian respiratory complex I
… aspect of the pharmacology of complex I is drug-induced mitochondrial dysfunction, particularly its role in liver toxicity. Complex I inhibition causes an energy deficit and can lead to adverse changes in the status of the mitochondrial [NADH]/[NAD+] pool and increased reactive oxygen …
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Investigating the Spatiotemporal Variation in Functional Markers, Gut Metabolites and Ethanol Toxicity in In Vitro Cultures of the Rat Jejunum and Hepatocytes
… including the absorption and bioavailability of drugs and bile and nitrogen homeostasis. It is important to study these two organs together to gain a holistic understanding of their communication with each other. However, there is a lack of culture models that investigate the use of primary …
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The liver in disease: with special reference to aspiration liver biopsy
… applications of the method to the assessment of drug toxicity and the efficacy of therapeutic agents.
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Optimization of cell adhesion environments for a liver cell bioreactor
… it a valuable tool for applications such as drug toxicity models and biosensors. Cell adhesion is an important factor in the maintenance of differentiated hepatocyte functions. Hepatocyte adhesion environments were examined in two settings: spheroid culture prior to seeding in the bioreactor …
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SILOXANE-CONTAINING PHOSPHOLIPIDS AS POTENTIAL DRUG DELIVERY SYSTEMS
Drug delivery systems (DDS) have become an important focus research over the past three decades with the emergence of new therapies based on biomolecules such as peptides, DNA, enzymes etc., with the aim of improving or optimising the potency of these biomolecules. Liposomes are colloidal vesicles …
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The characterisation of a fenoprofen prodrug
The term "prodrug" refers to a pharmacologically inactive compound that is converted to an active drug by a metabolic biotransformation. A nonenzymatic process, such as hydrolysis, can activate a prodrug via several routes. Prodrugs are mostly used to improve a drug's physical and chemical …
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The susceptibility of baboons to the novel immunosuppressant, FTY720
… including immunological complications and drug toxicity e.g. nephrotoxicity, remains a serious problem. Since the drugs currently available for allotransplantation preferably target T -cells, and are therefore unlikely to be sufficient for xenotransplantation where there is a strong B-cell …
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A high-content multiplexed screening platform for the evaluation and manipulation of force and fatigue of adult derived skeletal muscle myotubes in defined serum-free medium
… functional systems that can be validated for drug testing by the Food and Drug Administration (FDA). Also, the study of age related diseases as well as the potential for “personalized medicine” relies on the proliferation and maturation of satellite cells from adult derived tissue. For that …
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Cardiac organoid technology and computational processing of cardiac physiology for advanced drug screening applications
… its inception to advance disease modeling and drug screening. This is especially true for tissues that are difficult to study due to tissue sensitivity and limited regenerative capacity, such as the heart. Previous work in stem cell-derived cardiac tissue has exploited how we can engineer …
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Development of a HPLC method for the determination of methotrexate (MTX) and MTX-polyglutamates of red blood cells: A dissertation submitted in partial fulfilment of the requirements for the Degree of Bachelor of Science with Honours at Lincoln University
… arthritis (RA). Patient response to, the drug and development of side effects are poorly understood. There is large a variation in clinical response between patients and this influences the dose requirement. Therefore, there is a need for therapeutic drug monitoring to ascertain clinical …
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New phosphorescence based probes and techniques for the analysis of cellular oxygen and respiration
… bioenergetics, mitochondrial function and drug toxicity. This thesis presents the development and evaluation of new luminescent probes and techniques for intracellular O2 sensing and imaging. A new oxygen consumption rate (OCR) platform based on the commercial microfluidic perfusion channel …
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