Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 55 for “"Drug therapies"”.
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Economic evaluation of three preventive drug therapies for osteoporotic fractures among women at different risk levels
… To evaluate cost-effectiveness (CE) of three drug therapies for preventing osteoporotic fractures in postmenopausal women from a state Medicaid Program perspective using the estimated risk distribution in the study population. The three therapies are: hormone replacement therapy (HRT), …
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The path from clinical evidence to use of drugs – Marketing analysis of factors influencing the market performance of drug therapies = A klinikai evidencia útja a gyógyszerhasználatig – A gyógyszerhatóanyag terápiák piaci teljesítményére ható tényezők marketing szemléletű elemzése
A gyógyszeripari kutatás eredményeként egy-egy kielégítetlen orvosi igényre többféle hatásmechanizmus és ezen csoportokon belül több hatóanyag születik válaszként. A gyógyszerkutatás marketing szempontból a hatásmechanizmusok szintjén valóban eltérő megoldásokat kínál az igények kielégítésére, míg …
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Analytics for Improved Cancer Screening and Treatment
… propose a methodology for designing combination drug therapies for advanced cancer, evaluating our approach using advanced gastric cancer. First, we build a database of 414 clinical trials testing chemotherapy regimens for this cancer, extracting information about patient demographics, study …
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Psychosocial Predictors of Survival in Persons with HIV or AIDS
… of HIV and AIDS. Combination therapy of drugs has been shown to keep viral replication at very low levels. The result of drug therapies has resulted in keeping persons with HIV from progression to full blown AIDS. Also, drug therapies are responsible for a significant drop in mortality …
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Identification and Inhibition of Fosfomycin Resistance Enzymes for Structure-Based Drug Design
… companies turning away from the traditional drug development pipeline. One alternative method to address AMR is through repurposing existing approved drugs such as by utilizing combination drug therapies. Combination drug therapies often involve the inhibition of antibiotic modifying enzymes …
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Collateral sensitivity and the evolution of drug resistance in Escherichia coli
… have created excitement for designing new therapies that could reduce rates of evolution of antibiotic resistance in pathogens. To explore this idea, I tested the key assumption that collateral sensitivity should reduce the frequency of mutation to resistance. Ceftazidime resistant strains …
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Genetics and epigenetics of direct and indirect radiation responses in normal mammary and breast cancer cells
… cells, and cancer cells resistant to common drug therapies. The results presented here show that ionizing radiation initiates immune and apoptotic response in normal cells, and causes epigenetic alterations that may lead to genomic instability. In addition, our results demonstrate …
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A Mathematical Model of the Iron Regulatory Network in Aspergilus Fumigatus
… regulatory network are believed to be potential drug targets since iron management in fungi is vastly different from that in mammals and other eukaryotes. Therefore a better understanding of iron homeostasis in Aspergillus fumigatus could help improve drug therapies for invasive aspergillosis. In …
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Massively parallel combinatorial microbiology
… like microbial consortia and combinatorial drug therapies.
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A Numerical Study of a Delay Differential Equation Model for Breast Cancer
… cells and investigate the impact of certain drug therapies on the cancer. We use delay differential equations to model the interaction of breast cancer cells with the immune system. The new model is constructed by combining two previous models. The first model accounts for different cell …
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Comparison of treatments for upper respiratory tract infections recommended in community pharmacies and hospitals in North East Thailand.
Comparative treatments for URTIs in terms of drug therapies, cost and outcomes were evaluated in community pharmacies and hospitals in Mahasarakham province, NE Thailand. A total of 1052 URTI patients was studied, 536 patients in two hospitals (H) where physicians diagnosed and prescribed and 516 …
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Drug prescribing and administration changes in hospitalized geriatric patients : analysis of three drug utilization review programs
… patients or 0.5% of the population. The use of drugs in this population comprises approximately 25% of the prescription drug market in the United States which is directly related to the greater occurrence of pathological problems associated with the aging process. While it is evident that the …
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Methods for Identifying Subcellular Targeting Ligands and Selected Applications
… plays an essential role in targeting drug therapies as generally the pro-drug or linker relies on physical conditions of a particular subcellular compartment to function. We developed two methods that allow for selecting targeting ligands that both internalize specifically in cancer …
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Pharmacovigilance in Post-Marketing: Risk Assessment and Reporting Standards
<p>While there has been new targeted drug therapies released into the market over the recent years, pulmonary arterial hypertension (PAH) remains to be a rapidly progressive disease with poor prognosis. Over time the arteries stiffen and tighten subsequently leaving the heart to pump harder to try …
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Quantitative analysis of TLR-4-mediated cell responses in murine macrophages
… targets, JNK and ERK, for development of drug therapies against bacterial infection.
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Finding Combinatorial Connections between Concepts in the Biomedical Literature
… cross-talk in signaling networks, designing drug therapies for combinatorial selectivity, and unraveling the role of gene interactions in deleterious phenotypes, where the cost of performing combinatorial screens is exorbitant. In this thesis, we present an automated approach to biological …
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Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device
… of this thesis was to advance an implantable drug delivery MEMS (MicroElectroMechanical Systems) device developed in our laboratory. This device was designed to locally deliver multiple substances in complex release profiles in order to maximize the effectiveness of drug therapies. It consists …
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Tensile Properties of Single Vaginal Smooth Muscle Cells
… for improving current treatments like drug therapies, surgical procedures, medical grafts and implants, and preventative practices like stretching and exercise techniques.
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Development of Specific Inhibitors that Prevent hnRNPA1-Mediated Therapy Resistance in Small Cell Lung Cancer.
… year. This indicates that SCLC cells have a multidrug resistance to therapies subsequently leading to poor prognosis. Fibroblast growth factor 2 (FGF-2) signalling leads to cell death resistance by providing cancerous cells with survival signals that leads to therapy resistance. FGF-2 signalling …
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Evaluation of Lysobacter enzymogenes C3 for control of soybean fungal diseases
… numerous novel antimicrobials relevant to human drug therapies and crop protection. We first used in vitro assays to establish LeC3’s efficacy against the following soybean-pathogenic fungi and oomycetes: Cercospora sojina, Fusarium virguliforme, Macrophomina phaseolina, Phytophthora sojae, …
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