Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 279 for “"Drug targets"”.
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Assessment of potential antibacterial drug targets
The alarming increase in antibacterial drug resistance indicates an urgent need to develop new drugs. This project aimed to assess and select potential antibacterial targets and carry out initial biochemical characterisation concentrating on enzymes from biowarfare agents <i>Bacillus anthracis</i>, …
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Identification of potential drug targets in glioblastoma using proteogenomic platforms
… ing a major dilemma for immunotherapy and new drugs development. GSCs cells reside in multiple sites located inside the tumour mass characterised by hypoxia, acidic stress, and/or glucose restriction. Hypoxia has been shown to promote a stem-like state in tumour cells by activating …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… target as well as testing anti-retroviral drugs’ efficacy for the treatment of these tumours. I have demonstrated that HERV-K (HML-2) Env overexpression (Env o/e) in primary Schwann cells resulted in increased proliferation and elevated expression of the transcription factor cJun. Env o/e …
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Therapeutic strategies of Parkinson's disease: Alternative dopamine replacement and potential drug targets
The complex and prolonged disease course exhibited by Parkinson's disease (PD) first starts with non-motor disturbances and then slowly progresses to mild-to-moderate motor deficits, ultimately inflicting severe movement impairment and cognitive decline. Dopamine deficiency resulting from …
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Structure of T6SS components and assessment of potential Gram-ve drug targets
… VI secretion system and therefore a potential drug target. <br/>In chapter 4, the structure of S. marcescens Rap1b is described. This protein is thought to be part of a set of periplasmic resistance proteins that protect S. marcescens from succumbing to the effects of its own secreted toxins. …
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Investigation of O-acetylserine sulfhydrylase enzymes from bacterial pathogens as potential drug targets
… strategies. Among the most concerning drug-resistant pathogens are Neisseria gonorrhoeae and Staphylococcus aureus, both of which lack a functional sulfate reduction pathway, rendering them reliant on alternative sulfur acquisition mechanisms. A key enzyme in the de novo biosynthesis of …
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Investigation into potential Dirofilaria immitis drug targets through rational anthelmintic synthesis and design
… their activity on the anthelmintic receptor targets of interest, ACC-2 which is an acetylcholine-gated chloride channel unique to nematodes and the UNC-49 GABA receptor. In total, 22 compounds, 12 of which are novel, were synthesized, including imidazole-4-acetic acid like compounds, …
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Discovery of high quality molecular leads and screening collections for CNS drug targets
… pharmaceutical industry few disease modifying drugs have been discovered with the most common cause of late stage clinical failure being a lack of efficacy. In order to enable greater understanding of disease mechanisms and the ability to validate specific biological targets for disease …
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Enzymes as Drug Targets in the Isoprenoid Biosynthesis Pathway: Structure, Mechanism and Inhibition
… Several of them have been identified as drug targets. Here we reported the inhibition study of isopentenyl diphosphate/dimethylallyl diphosphate isomerase (IPPI) and deoxyzylolus reductoisomerase (DXR), along with crystal structures of enzyme inhibitor complexes. A high throughput …
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Osteopontin and Cadherin 11 Are Novel Mediators and Drug Targets For Chronic Lung Diseases
… results of this study propose CDH11 as a novel drug target for PF. In addition, another CLD, chronic obstructive pulmonary disease (COPD), is characterized by airway inflammation and destruction. Adenosine, a nucleoside signaling molecule generated in response to cell stress is upregulated in …
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Characterising the functional homology of central nervous system drug targets in larval zebrafish (Danio rerio)
… Central nervous system (CNS)-targeting drugs are of particular concern because they are designed to act at low concentrations on highly conserved molecular targets. While sequence-level conservation of these targets between humans and fish is well established, it remains unclear whether …
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Identification and Characterization of Drug Targets in the Pyrimidine and Purine Pathways of Trypanosoma brucei
… of effective, safe, and simple to administer drugs, my work sought to identify and characterize novel drug targets in the parasite pyrimidine and purine pathways. The pyrimidine de novo biosynthetic pathway has been well characterized, however little work had been done to evaluate the …
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Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets
… IRAK2 and IRAK3, to evaluate their potential as drug targets. Chapter 5 centres on the interaction of the E3 ubiquitin ligase TRAF6 with IRAK2 and IRAK3.<br/><br/>I discovered that the kinase domain of IRAK2 is monomeric in solution, while IRAK3 is in a concentration-dependent equilibrium of …
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Inhibition of a Mycothiol biosynthetic enzyme and a detoxification enzyme as anti-tubercular drug targets
Includes abstract. Includes bibliographical references (leaves 131-141).
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Characterization of alternative NADH dehydrogenases in the respiratory chain of Toxoplasma gondii as a novel drug targets
Das singuläre Mitochondrium der schnell replizierenden Tachyzoiten von Toxoplasma gondii generiert ein Membranpotential, über dessen Beitrag zum Energiestoffwechsel des Bradyzoiten- oder Ruhestadiums des Parasiten bisher wenig bekannt ist.Die steady state mRNA-Konzentration von 11 nukleär-kodierten …
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Investigating the impacts of resistance mutations in Mycobacterium tuberculosis in order to improve the selection of new drug targets
Drug-resistant tuberculosis (TB), one of the leading causes of death worldwide, arises mainly from spontaneous mutations in the genome of Mycobacterium tuberculosis (M. tb). There is an urgent need to understand the mechanism by which the mutations confer resistance in order to design new drugs to …
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G-Triple Chemiluminescent DNAZyme Based Biosensor for the Detection of Calcium(II) Ions in Solution and the Biological Functionality of Kinase Enzymes and the Rationale for their Employment as Promising Drug Targets, Substrate Specific Inhibition of P38alpha
… is seen in clinical trials, where the drug will decrease the disease severity for patients for only a few months. Previously, it has been determined that rooperol, a polyphenolic compound, is able to inhibit the activity of p38a by binding to the docking recruitment site (DRS) instead …
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The Landscape of Host Transcriptional Response Programs Commonly Perturbed by Infectious Pathogens: Towards Host-Oriented Broad-Spectrum Drug
… of pathogens to adapt and develop resistance to drugs, and (ii) a shortage in the development and discovery of new anti-infective drugs. Host-Oriented Broad-Spectrum (HOBS) treatments have the promising potential to alleviate these problems. The HOBS treatment paradigm focuses on finding drug …
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Genome scale metabolic modelling to identify metabolic responses of resistant bacteria to antibiotic challenges
… In order to explore solutions for AMR, INNOTARGETS , a consortium of academic and industrial partners has been established, with the objective of applying innovative approaches for identifying metabolic drug targets in resistant pathogenic bacteria. In this thesis, genome-scale metabolic …
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Towards precision medicine in psychiatry: investigating the contribution of cellular aging, pleiotropy and gender differences in psychiatric disorders and pharmacological response
… also be of help to identify novel potential drug targets. In this thesis, we focus on the investigation of molecular markers related to cellular aging (telomere length) and inflammation in predisposition to severe mental disorders and response to psychotropic treatments. In addition, we …
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