Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 225 for “"Drug target"”.
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Mycothiol disulfide reductase as a drug target
Includes abstract. Includes bibliographical references (leaves 154-171).
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DAF-12: A Novel Drug Target in Parasitic Nematodes
… introduces the the first well-defined molecular target for controlling the spread of this important pathogen. Additionally, an ortholog with significant sequence and likely functional similarity is identified in the related parasite Globodera pallida, which causes an identical disease in other …
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DAF-12: A Novel Drug Target in Parasitic Nematodes
… introduces the the first well-defined molecular target for controlling the spread of this important pathogen. Additionally, an ortholog with significant sequence and likely functional similarity is identified in the related parasite Globodera pallida, which causes an identical disease in other …
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Exploring IPC Synthase: A POTENTIAL ANTI -LEISHMANIAL DRUG TARGET
… „1‟ by WHO–TDR in 2004. Currently available drugs are expensive and difficult to administer with toxic and/or teratogenic side effects. In addition, there are increasing levels of drug resistance. Therefore, there is a need for new effective drug treatments. Earlier work in the group …
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Exploring Protoheme IX Farnesyltransferase as an Antimalarial Drug Target
… combat the rapidly increasing prevalence of multidrug resistant Plasmodium species parasites that cause malaria. Recent advances in technology to genetically modify malarial parasites and methods for high throughput screening of compounds allow for increased understanding of Plasmodium biology and …
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Identifying drug-target and drug-disease associations using computational intelligence
Background: Traditional drug development is an expensive process that typically requires the investment of a large number of resources in terms of finances, equipment, and time. However, sometimes these efforts do not result in a pharmaceutical product in the market. To overcome the limitations of …
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Leishmania CRK3:CYC6 cyclin-dependent kinase as a drug target
Leishmania species are protozoan parasites which have a complex life cycle, which is coordinated with its cell cycle. There are 11 cyclin dependent kinases (CDKs) and 11 cyclins present in the Leishmania genome reflecting the complexity of cell cycle control in this parasite, perhaps due to the …
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High-dimensional machine learning for drug target discovery and precision medicine
… or cancer is essential to discover molecular targets for therapeutic intervention, ideally in a personalized manner. Gene expression measured in a tissue sample is an informative proxy to the protein levels in that tissue and known to drive disease outcomes. Machine learning offers promising …
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Isoprenoid Biosynthesis Pathway as a Drug Target for Bisphosphonates: Transcriptional Profile Investigation
… which in combination with the phosphonate drug fosmidomycin exerted a potent synergistic effect in Escherichia coli. Additionally, we designed novel groups of bisphosphonates which are ∼10-1000 fold more potent against tumor cell lines than conventional bisphosphonates due to their …
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Exploring Potential Drug Target Sites In The Ribosome Using Cisplatin And Its Analogues
… (II), cisplatin, is an antitumor drug that has been used to treat several types of cancers. The reaction of cisplatin with DNA has been studied and discussed extensively in the literature; however, the effects of cisplatin on RNA function are poorly understood. In this thesis, two …
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Network Models for Capturing Molecular Feature and Predicting Drug Target for Various Cancers
… of molecular vulnerabilities and the development targeted therapy. Based on this rationale, we conducted the following four studies: A novel algorithm ‘FFBN’ is developed for reconstructing directional regulatory networks (DEGs) from tissue expression data to identify molecular features. ‘FFBN’ …
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Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes
… all parasite species or disease stages and drug resistance is an increasing problem. Protein kinases are well validated drug targets for a variety of human diseases with many inhibitors under development or in the clinic. The T. brucei kinome has been annotated and there is evidence of …
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Computational analysis of biochemical networks for drug target identification and therapeutic intervention design
Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear that a holistic network approach is needed to identify drug targets that are …
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Biochemical analysis of a potential drug target in the human protozoal pathogen Trichomonas vaginalis
… metronidazole. This provoked researchers to target hydrogensosomal enzymes such as pyruvate: ferredoxin oxioreductase and ferredoxin, to treat trichomoniasis caused by T. vaginalis. Recent studies have shown alternative pathways responsible for activating metronidazole without the involvement …
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Chemical Genetic Approaches for Elucidating Protease Function and Drug-Target Potential in Plasmodium Falciparum
… annually. With the increasing prevalence of drug-resistant parasites, considerable interest now exists in the identification of new biological targets for the development of new malaria chemotherapeutics. However, given the genetic intractability inherent in studying P. falciparum, it is …
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Predicting drug - target interaction network using deep learning models for drug repurposing through genetic information
… that biological and experimental methods for drug discovery are time-consuming and expensive. New efforts have been explored to perform drug repurposing through predicting drug-target interaction networks using biological and chemical properties of drugs and targets. However, due to the …
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Comprehensive single and paired drug target identification in healthy and disease models of NF-kB pathway
… in the NF-[kappa]B pathway that if inhibited/ targeted by added drugs normalize the levels of NF-[kappa]Bn. Also, since there is a limit to how effective single drug targets are in complicated diseases, identification of combinations of targets is very important. Existing experimental and …
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Computational modeling of knowledge and uncertainty in systems biology for drug target identification and protein engineering
… involved in immune response, to find promising drug targets for treatment of sepsis. I compared a sampling method to a worst-case search method for quantifying the uncertainty in responses to hypothetical inhibitors and found that the choice of method significantly impacts the results. I …
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Development and Application of Large-Scale Protein Folding Stability Analysis in Drug Target Identification and Disease Biomarker Discovery
… protein folding stability approaches in drug target identification and disease biomarker discovery. One goal of this work is to develop a novel chemo-selection strategy to improve the bottom-up proteomics readout in proteome-wide limited proteolysis experiments. Another goal of this work …
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