Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Drug synthesis"”.
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The synthesis and reactivity of 6- and 8-azaindolizines.
… substituted 6- and 8- azaindolizines have been synthesised via the Chichibabin reaction between suitably-substituted 2- or 4- methylpyrimidines and alpha-bromo ketones. The structures of the products obtained have been confirmed spectroscopically, principally by 'H NMR spectroscopy, and by …
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Solid phase peptide synthesis and TLR-5 activity analysis of pertide fragments from the Salmonella muenchen flagellin protein
Drug design strategies begin by determining the simplest ligand necessary to activate a receptor of interest. The Toll-Like Receptor-5 (TLR-5) is an attractive target for pharmaceutical modulation because it initiates an innate immune response. A TLR-5 agonist or antagonist could help remedy a …
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Design, synthesis and evaluation of small molecules as inhibitors of plasminogen activator inhibitor-1
… heart disease. Currently, there is no Food and Drug Administration approval for inactivating higher levels of PAI-1. Therefore, PAI-1 is considered an attractive drug target. Due to PAI-1’s different structural conformations and multiple binding domains, development of PAI-1 inhibitors is a …
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Synthesis and Biological Evaluation of Novel Glycomimetics
… such as cancer, energy production and biosynthesis of glycoproteins are dysregulated. This thesis explores two methods for the synthesis of molecules that interfere with these processes and, therefore, can be potential starting points in a drug discovery programme. The first method is to …
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Quantum computational chemistry methods for early-stage quantum computers
… areas such as chemistry, materials science and drug synthesis. Modelling of molecules, which are classically intractable, can be achieved with just over $30$ qubits, whereas state of the art quantum computers already have more than $50$ qubits. The Variational Quantum Eigensolver (VQE) algorithm …