Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Drug stability"”.
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The determination of drug stability by HPLC assay of degradation products.
This work evaluates the advantages in drug stability testing of following the decomposition by analysis of decomposition products. Conventional methods of drug stability testing are criticised and the limitations are shown to be largely a result of analysing for un-decomposed drug. Using simulated …
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A compatibility profile of selected therapeutic agents in balanced electrolyte solutions
… the prevalent practice of adding one or more drugs to parenteral fluids. The greater variety of drugs being used intravenously, plus the formulation of newer and more complex parenteral fluids, has led to an increased awareness of potential incompatibilities existing between drug and solution. …
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Bayesian methods in non-clinical pharmaceutical statistics.
… processes for aseptic manufacturing of drug products. Since the assessment of the sterility of manufacturing equipment and product is fundamentally an assessment of probability, we show that a Bayesian approach permits validation conclusions to be made based on the quantification of the …
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Phase equilibria from molecular simulation
… such as their solubility, manufacturability, and stability. They are of significant industrial and commercial interest, perhaps most importantly to the pharmaceutical industry where drug stability and solubility are two of the largest challenges of drug development. The focus of this thesis then …
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The surface characterisation of pharmaceutical mini-tablets using thermal probe techniques
… into contact with the environment, and where drug stability and excipient functionality are critical. Mini-tablets provide a good model system for surface characterisation, as they have much higher surface area to volume ratios than conventionally sized tablets. Five excipients and two drugs, …
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Solid dispersions: formulation, characterisation, permeability and genomic evaluation
… Formulation of solid dispersion of the drug has attracted considerable interest as a means of improving dissolution process of a range of poorly water soluble drugs. This current study investigates the formulation of solid dispersion for a range of poorly water soluble drugs with varying …
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Applications of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) in pharmaceutical analysis
… that can economise production processes for drug formulations. BARDS is based on reproducible changes in a solvent's compressibility as a sample dissolves. It is a rapid and straightforward method that utilises a magnetic stir bar to mix added solute and induce a vessel's acoustic resonance …
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Beta-Lapachone Nanotherapeutics for Lung Cancer Therapy
… β-Lapachone (β-lap) is a novel anticancer drug whose mechanism of action relies on its bioactivation by the enzyme NAD(P)H:quinone oxidoreductase-1, NQO1, found overexpressed in NSCLC. While promising, its low water solubility limits its clinical translation. Moreovoer, a clinical …
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Towards Photoredox-Cleavable Prodrugs
… molecules from inactive precursors, e.g. prodrugs. Photouncaging is most often achieved through a direct release approach employing a chromophore as the photocaging group, which absorbs light and followingly undergoes cleavage. While this approach operationally simple, it requires complex …
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Metabolic Factors Determining Outcome in Chemotherapy: Studies with Pazopanib
… metabolic pathways involved in the metabolism of drugs have either been deleted or humanised in order to delineate the impact that such systems have on drug metabolism, distribution, and efficacy. These pathways include the cytochrome P450-dependent monooxygenase system and the constitutive …
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In vitro comparison of methylene diphosphonate radiopharmaceuticals
… for their binding efficiencies, stability, and subsequent changes due to varying technetium levels. </p>
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Precipitation of micro/nanoparticles in enhanced high energy dissipation mixing systems
… active ingredients. Rapid development of a drug candidate is dependent on the ability to produce a desired drug substance with consistent properties, These properties include stability and purity, which are directly affected by the crystallization process and which affect, in turn, …
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Study of drug delivery and cell encapsulation using biocompatible hydrogel
… are becoming an attractive means to mediate drug delivery or facilitate cell-based treatment of diseases. These particles are capable of maintaining drug stability/cell viability and providing specific drug release profiles. The selection of specific hydrogel and particle size depends on the …
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Stability of drugs and pesticides of forensic toxicological interest and their metabolites in biological samples
… the studies in this thesis was to evaluate the stability of some important drugs and compounds in blood under different storage conditions in order to optimize the preservation of these compounds. A second aim was to evaluate a new method of stabilizing these compounds in blood by storing them …
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Lipid Nanoparticles as Tools for the Administration of Active Natural Products Aimed to the Treatment of Nervous System Disorders
… based on natural compounds, as old synthetic drugs cause numerous side effects. Curcumin (CUR) and astaxanthin (AST) are two natural antioxidants that possess therapeutic properties for the treatment of AD, although they show poor biovailability due to their high lipophilicity. In order to …
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A Novel Interleukin-15 Receptor Antagonist for the Treatment of Rheumatoid Arthritis
… advantages over peptides, such as increased stability, enhanced bioavailability, and reduced immunogenicity, making IFRA3Q1 a promising therapeutic candidate. The primary objectives of this research are to validate IFRA3Q1’s efficacy in reducing RA symptoms in preclinical models and to …