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Showing 1 to 20 of 35 for “"Drug solubility"”.
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Release adjustment of drug combinations with different drug solubility
Formulation issues of drug combination in one dosage form could be due to different solubility of drug which will give different release profile. The objective of present study is therefore to adjust the release of two drugs of different solubility in drug for controlled release drug delivery as …
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Spray drying as part of the continuous manufacturing value proposition at Novartis
… of their manufacturing processes. To date, all drugs have been made by using a batch process. In an attempt to lower costs, Novartis is evaluating moving some drug production to a continuous process. Novartis has instituted lean in their production plants and it has been very successful, but …
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A Dual Approach of Salt Formation and Amorphous Solid Dispersion for Improved Oral Drug Delivery
Poorly water-soluble drugs are characterized by their limited dissolution in the gastrointestinal (GI) tract that causes reduced bioavailability and suboptimal therapeutic outcomes. Drug solubility is a crucial factor that influences the absorption and bioavailability of orally administered drugs. …
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Nanoparticles Targeting at Inflammation Site
… evaluation of advanced nanoparticle-based drug delivery systems designed for the sustained and localized delivery of hydrophobic therapeutics, with a focus on pazopanib. Addressing key challenges in drug solubility, stability, and scalable manufacturing, this work explores polymeric, …
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Cellulose Esters and Cellulose Ether Esters for Oral Drug Delivery Systems
… dispersion (ASD) is a popular method to increase drug solubility and consequently poor drug bioavailability. Cellulose ω-carboxyesters were designed and synthesized specifically for ASD preparations in Edgar lab that can meet the ASD expectations such as high Tg, recrystallization prevention and …
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MULTIFUNCTIONAL SUPRAMOLECULAR DELIVERY SYSTEM FOR ENHANCING TUMOR IMMUNOTHERAPY
… These engineered carriers address challenges in drug solubility, targeting, and immunotherapy. The findings highlight the potential of β-CD-based systems to revolutionize cancer immunotherapy, providing valuable insights for future research.
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Supramolecular modification of selected antiretroviral drugs
A number of antiretroviral drugs that are currently in use for anti-HIV therapy have extremely poor aqueous solubility. This, along with the fact that many of these pharmaceutical compounds possess potential hydrogen bond donor and acceptor functionalities, makes them ideal candidates for attempted …
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Water-insoluble polymers as binders for controlled release matrix and reservoir pellets
… release pellets includes preparation of drug cores using water-soluble binders, followed by coating with release-controlling polymers. The main objective of this work was to investigate the applicability of water-insoluble polymers, usually used for coating, as binders for pellets …
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Investigation of Enhancement of Furosemide Solubilization with Cyclodextrins and a Novel Octenyl Succinate Anhydride Starch
<p>Solubility behavior is one of the most challenging aspects for drug commercialization and often the main reason of drug that do not reach to its full potential. Now nearly 60% new chemical entities possess solubility problems, whereas practically no drug products with less than 10 µg/ml …
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Interações da trancinolona com ciclodextrinas em sistemas multicomponentes
… is a relevant anti-inflammatory costicosteroid drug, used mainly by injectable suspensions due its poor water solubility. The association of triamcinolone with cyclodextrins and co-solvents (triethanolamine TEA and N-methylpirrolidone NMP) was held to solubilize the drug and explain the involved …
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Bioaktyviųjų joninių skysčių aukštosios skyros BMR tyrimas /
… b-RTIL can be used in medicine by increasing drug solubility in water. NMR spectroscopy is used to analyse b-RTILs – choline lysinate, choline tryptophanate and choline glycinate ([Ch][Lys], [Ch][Trp] and [Ch][Gly]). Also, with NMR we can analyse [Ch][Lys] interaction with water molecules by …
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Fabrication of complex oral drug delivery forms by Three Dimensional Printing (tm)
… to the fabrication of complex pharmaceutical drug devices. Limitations of the technology as relating to pharmaceuticals have been addressed and prototype dosage forms have been fabricated. The resolution of the 3DP tablets was found to depend on particle size and liquid migration during …
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Synthesis and Structure-property Evaluation of Novel Cellulosic Polymers as Amorphous Solid Dispersion Matrices for Enhanced Oral Drug Delivery
… and increasingly widely adopted approach for solubility and bioavailability enhancement of hydrophobic drugs. Cellulose derivatives have strong potential as ASD polymers. We demonstrate herein design, synthesis and structure-property relationship characterization of a new series of …
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Dissolution Behavior of Amorphous Solid Dispersions
Current drug discovery techniques tend to identify potential new drug entities with more complex structures which may pose significant formulation challenges. In particular, an increasingly large number of new drug compounds have extremely poor solubility in water, impacting the bioavailability of …
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Design and Development of Biocompatible MOFS and Silica-Based Nanocarriers with Controlled Pharmacokinetics for Drug Delivery Applications
… and silica-based materials as nanocarriers for drug delivery applications, owing to their exceptionally high surface area and highly structured porous network. The overall goal of this research was to optimize the pharmacokinetic behavior of several highly porous biocompatible drug carriers that …
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Novel Methods for Co-crystallisation
… is a slurry based technology where, effects of drug solubility and dielectric properties of the solvent were investigated using caffeine / maleic acid as a model co-crystal pair. The mechanism of co-crystallisation under microwave irradiation has been proposed. The co-crystals of plumbagin with …
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Cyclodextrin complexes of antimicrobial agents
Poorly water-soluble drugs show an increase in solubility in the presence of cyclodextrins (CyD) due to the formation of a water-soluble complex between the drug and dissolved CyD. This study investigated the interactions of -Cyd and hydroxypropyl--CyD (HP--CyD, M.S. = 0.6) with antimicrobial …
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Development and Intratumoral Distribution of Block Copolymer Micelles as Nanomedicines for the Targeted Delivery of Chemotherapy to Solid Tumors
… have resulted in the creation of novel drug delivery systems with the potential to revolutionize current strategies in cancer chemotherapy. In oncology, realization of significant improvements in therapeutic efficacy requires minimization of drug exposure to healthy tissues and …
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Development of antibiotic microneedle delivery systems for tuberculosis treatment
… (MN) arrays to transdermally deliver TB drugs, namely rifampicin, isoniazid, pyrazinamide and ethambutol, which have different physicochemical properties. These drugs were individually prepared into three types of drug reservoirs, including lyophilised tablets, directly compressed tablets …
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Local drug delivery for treatment of brain tumor associated edema
… for normal physiological functions. A miniature drug delivery device was developed for local drug delivery in rodents. It comprises of a drug reservoir and a cap with orifice(s) through which drug is released. Drug release kinetics is dependent on the payload, the drug solubility, and the surface …
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